Genomics

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Genetic and lifestyle factors linked to brain network aging, study reveals

Research highlights the impact of genetic and lifestyle factors on a brain network particularly sensitive to aging, schizophrenia, and Alzheimer's disease, using data from nearly 40,000 UK Biobank participants to investigate modifiable risk factors and genetic associations.

28 Mar 2024

Genetic test streamlines diagnosis of rare developmental disorders

A single genetic test could potentially replace the current two-step approach to diagnosing rare developmental disorders in children. This shift could enable earlier diagnoses for families and save the NHS vital resources.

28 Mar 2024

Study sheds light on the interplay of genes in smoking addiction

Take a puff of nicotine for the first time, and your DNA plays an important role, alongside social and environmental factors, in shaping what happens next.

26 Mar 2024

New genetic system analyzes the underlying mechanisms of CRISPR-based DNA repair outcomes

Since its breakthrough development more than a decade ago, CRISPR has revolutionized DNA editing across a broad range of fields.

26 Mar 2024

GPT-4 shows expert-level accuracy in annotating cell types

GPT-4 can accurately interpret types of cells important for the analysis of single-cell RNA sequencing -- a sequencing process fundamental to interpreting cell types – with high consistency to that of time-consuming manual annotation by human experts of gene information, according to a study at Columbia University Mailman School of Public Health.

26 Mar 2024

Study reveals genetic variant linked to increased risk of leukemia in Hispanic/Latino children

Acute lymphoblastic leukemia (ALL), the most common childhood cancer, disproportionately affects children of Hispanic/Latino origin in the United States.

26 Mar 2024

Nucleus Genomics ushers in a new era of personalized medicine to the public

Nucleus Genomics, the next-generation genetic testing and analysis company, today announced the launch of its DNA analysis product to bring the benefits of personalized medicine to everyone.

25 Mar 2024

ANU scientists uncover gene mutation driving psoriasis and psoriatic arthritis

Scientists from The Australian National University (ANU) have discovered a gene mutation is responsible for causing psoriasis – a chronic inflammatory skin disease that causes patients to develop red, scaly and itchy patches across their body.

25 Mar 2024

Unraveling epigenetic contributions to autoimmune skin diseases

The central dogma proposed that genetic information predominantly transfers from DNA to RNA during gene expression to make a functional product protein.

25 Mar 2024

Researchers shed light on proteins controlling the development of ovaries in mice

Researchers at the Francis Crick Institute have shed light on the proteins controlling the development of ovaries in mice before and after birth.

22 Mar 2024

Researchers create new platform to identify proteins for targeted treatment of disease

Researchers at the University of Toronto and Sinai Health have created a new platform to identify proteins that can be co-opted to control the stability of other proteins -; a new but largely unrealized approach to the treatment of disease.

22 Mar 2024

Boosting mRNA activity and longevity with multi-tailed structures

Messenger RNA (mRNA) made its big leap into the public limelight during the pandemic, thanks to its cornerstone role in several COVID-19 vaccines

22 Mar 2024

Aging linked to length of genes, study suggests

Aging may be less about specific "aging genes" and more about how long a gene is. Many of the changes associated with aging could be occurring due to decreased expression of long genes, say researchers in an opinion piece publishing March 21 in the journal Trends in Genetics.

22 Mar 2024

Long genes linked to faster biological aging

What causes our body to age? Four complementary studies, including one from Northwestern Medicine, have come to the same conclusion: long genes.

21 Mar 2024

Researchers devise novel technique for crafting human artificial chromosomes

Human artificial chromosomes (HACs) capable of working within human cells could power advanced gene therapies, including those addressing some cancers, along with many laboratory applications, though serious technical obstacles have hindered their development.

21 Mar 2024

Groundbreaking atlas maps over 80 blood stem cell types

Thanks to an unusual application of game theory and machine learning technology, a large team of scientists led by experts at Cincinnati Children's has published the world's most detailed "atlas" of the many types of stem cells and early progenitors involved in producing human blood from diverse donors.

21 Mar 2024

Using whole genome sequencing to identify non-culturable Legionella

Legionnaires' disease (LD), a rare and severe type of pneumonia, is a respiratory infection caused by species of Legionella bacteria.

21 Mar 2024

Scientists shed light on key immune regulators involved in Alzheimer’s and other disorders of lipid-rich tissues

Using novel genetic and genomic tools, researchers at the Icahn School of Medicine at Mount Sinai have shed light on the role of immune cells called macrophages in lipid-rich tissues like the brain, advancing our understanding of Alzheimer's and other diseases.

21 Mar 2024

Study pinpoints several genetic variants contributing to Alzheimer's disease

Identifying genetic variants and the role they play in predisposing people to Alzheimer's disease can help researchers better understand how to treat the neurodegenerative condition for which there is currently no cure.

21 Mar 2024