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Topline results from first of four Phase 3 studies of Pfizer's bapineuzumab for Alzheimer's

Pfizer Inc. announced today that the co-primary clinical endpoints, change in cognitive and functional performance compared to placebo, were not met in the Janssen Alzheimer Immunotherapy R&D LLC (Janssen AI)-led Phase 3 trial of intravenous (IV) bapineuzumab in patients with mild-to-moderate Alzheimer's disease who carry the ApoE4 (apolipoprotein E epsilon 4) genotype.

24 Jul 2012

Endoscopy, better tissue sampling required to improve care for patients with oesophageal cancer

The world's largest review of all the evidence on the best way of managing and treating common pre-cancerous and cancerous conditions of the oesophagus (gullet) has found that good endoscopy equipment, more endoscopic surgery, and more tissue sampling are required to improve care for patients.

24 Jul 2012

Michigan High School Athletic Association, U-M collaborate to offer free concussion education

Required online rules meetings for Michigan high school coaches this fall will include a concussion education module from U-M's Michigan NeuroSport and Pediatric Trauma Program at C.S. Mott Children's Hospital.

24 Jul 2012

Implementing population level changes could avoid up to 50% of deaths from CVD

Up to 50% of deaths from cardiovascular disease in Europe could be avoided by implementing population level changes such as taxation and regulation of advertising. Population level prevention will produce greater impacts on CVD than individualised approaches, according to the European Association for Cardiovascular Prevention & Rehabilitation (EACPR) of the European Society of Cardiology (ESC).

24 Jul 2012

Anti-IL-3 monoclonal antibodies to treat early stage Rheumatoid Arthritis in development

SuppreMol GmbH, an autoimmune disease specialist, today announced a licensing agreement with the University Hospital of Regensburg to develop SM401, a humanized anti-IL-3 monoclonal antibody for early diagnosis and treatment of Rheumatoid Arthritis (RA). SuppreMol will advance preclinical development of SM401 for treatment of RA. Simultaneously, the Company will further validate a highly sensitive human IL-3 diagnostic assay for patient stratification.

24 Jul 2012

Study represents new use of bone marrow transplantation

Researchers at Fred Hutchinson Cancer Research Center have opened a clinical trial to test the theory that giving a patient a new immune system can cure severe cases of Crohn's disease, a chronic inflammatory condition of the gastrointestinal tract.

24 Jul 2012

Debiopharm initiates Debio 8206 Phase III study on advanced prostate cancer

Debiopharm Group (Debiopharm), a Swiss-based global biopharmaceutical group of companies with a focus on the development of prescription drugs that target unmet medical needs and companion diagnostics, today announced the treatment of its first patient in a multicentre, open, non-comparative Phase III study to investigate the efficacy, safety, and pharmacokinetics of two subcutaneous (SC) injections of Debio 8206 (triptorelin pamoate 22.5 mg 6-month formulation) in patients with advanced prostate cancer.

24 Jul 2012

Tumor necrosis factor may play a key role in how light at night leads to depression

Chronic exposure to dim light at night can lead to depressive symptoms in rodents -- but these negative effects can be reversed simply by returning to a standard light-dark cycle, a new study suggests.

24 Jul 2012

Pancreatic cancer risk may be lowered by high dietary antioxidant intake

Increasing dietary intake of the antioxidant vitamins C, E, and selenium could help cut the risk of developing pancreatic cancer by up to two thirds, suggests research published online in the journal Gut.

24 Jul 2012

Researchers identify new class of compounds that inhibit spread of prions

A team of University of Alberta researchers has identified a new class of compounds that inhibit the spread of prions, misfolded proteins in the brain that trigger lethal neurodegenerative diseases in humans and animals.

24 Jul 2012

New laser technology can non-invasively destruct cancerous tumors

Researchers at the Center for Laser Applications at the University of Tennessee Space Institute in Tullahoma have developed a technology that goes on a "seek and destroy" mission for cancerous tumors. They have harnessed the power of lasers to find, map and non-invasively destruct cancerous tumors.

24 Jul 2012

Two thirds of obese children have heart disease risk factors

Two out of three severely obese kids already have at least one risk factor for heart disease, suggests research published online in Archives of Disease in Childhood.

24 Jul 2012

Aspirin use appears to reduce risk of Barrett's esophagus

Aspirin use appears to reduce the risk of Barrett's esophagus (BE), the largest known risk factor for esophageal cancer, according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association.

24 Jul 2012

UV induction of melanin is directly involved in melanoma formation

A new study conducted by GW School of Medicine and Health Sciences (SMHS) researchers Edward C. De Fabo, Ph.D., Frances P. Noonan, Ph.D., and Anastas Popratiloff, M.D., Ph.D., has been published in the journal Nature Communications. Their paper, entitled "Melanoma induction by ultraviolet A but not ultraviolet B radiation requires melanin pigment," was published in June 2012.

24 Jul 2012

Study reveals 50% increased risk of urothelial and colorectal cancers in adulthood

Parents are increasingly conscious of the dangers of childhood obesity. There is a growing recognition of health problems associated with extra pounds, including the risk of diabetes, heart disease, and joint and muscle pain.

24 Jul 2012

Top-line result from Pfizer Bapineuzumab Phase 3 studies on Alzheimer's

Elan Corporation, plc announced today that Pfizer has issued a top-line result in the first of four Bapineuzumab Phase 3 studies carried out by Pfizer and Janssen AI.

24 Jul 2012

Scientists identify mechanisms by which GLP-1 protects against kidney disease, diabetes

Scientists at Joslin Diabetes Center have identified biological mechanisms by which glucagon-like peptide-1 (GLP-1), a gut hormone, protects against kidney disease, and also mechanisms that inhibit its actions in diabetes.

24 Jul 2012

PAMAM G-3 actually prevents activation of the process that leads to thrombosis

A compound that mops up debris of damaged cells from the bloodstream may be the first in a new class of drugs designed to address one of medicine's most difficult challenges -- stopping the formation of blood clots without triggering equally threatening bleeding.

24 Jul 2012

Ocular Therapeutix announces results from sustained release OTX-TP1 study on glaucoma

Ocular Therapeutix, Inc. announced today initial results of their sustained release travoprost-loaded punctum plug feasibility study for the treatment of glaucoma. This travoprost punctum plug (OTX-TP1) was evaluated for the reduction of elevated intraocular pressure in subjects with open-angle glaucoma or ocular hypertension over a 30 day period.

24 Jul 2012

FDA approves Forest Laboratories’ Tudorza Pressair to treat COPD

Forest Laboratories, Inc. and Almirall, S.A. announced today that the U.S. Food and Drug Administration (FDA) has approved Tudorza Pressair (aclidinium bromide inhalation powder) for the long-term maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema.

24 Jul 2012

Medical Condition News

Topline results from first of four Phase 3 studies of Pfizer's bapineuzumab for Alzheimer's

Endoscopy, better tissue sampling required to improve care for patients with oesophageal cancer

Michigan High School Athletic Association, U-M collaborate to offer free concussion education

Implementing population level changes could avoid up to 50% of deaths from CVD

Anti-IL-3 monoclonal antibodies to treat early stage Rheumatoid Arthritis in development

Study represents new use of bone marrow transplantation

Debiopharm initiates Debio 8206 Phase III study on advanced prostate cancer

Tumor necrosis factor may play a key role in how light at night leads to depression

Pancreatic cancer risk may be lowered by high dietary antioxidant intake

Researchers identify new class of compounds that inhibit spread of prions

New laser technology can non-invasively destruct cancerous tumors

Two thirds of obese children have heart disease risk factors

Aspirin use appears to reduce risk of Barrett's esophagus

UV induction of melanin is directly involved in melanoma formation

Study reveals 50% increased risk of urothelial and colorectal cancers in adulthood

Top-line result from Pfizer Bapineuzumab Phase 3 studies on Alzheimer's

Scientists identify mechanisms by which GLP-1 protects against kidney disease, diabetes

PAMAM G-3 actually prevents activation of the process that leads to thrombosis

Ocular Therapeutix announces results from sustained release OTX-TP1 study on glaucoma

FDA approves Forest Laboratories’ Tudorza Pressair to treat COPD

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