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New ground-breaking initiative aims to find new treatments for leishmaniasis and Chagas disease

New ground-breaking initiative aims to find new treatments for leishmaniasis and Chagas disease

The Drugs for Neglected Diseases initiative and four pharmaceutical firms, Eisai Co Ltd, Shionogi & Co Ltd, Takeda Pharmaceutical Ltd, and AstraZeneca plc have announced the start of a ground-breaking initiative to accelerate and cut the cost of early stage drug discovery for two of the world’s most neglected diseases, leishmaniasis and Chagas disease. [More]
Scientists study active substance against dreaded hospital pathogen Staphylococcus aureus

Scientists study active substance against dreaded hospital pathogen Staphylococcus aureus

In the German Center for Infection Research (DZIF), scientists from the universities of Tübingen, Münster and Munich join forces and prepare together with the company Hyglos clinical studies on an active substance against the dreaded hospital pathogen Staphylococcus aureus: A highly effective protein from bacteria-specific viruses, so-called bacteriophages, shall rapidly kill the bacteria, which frequently occur in the nose. [More]
New study shows stem cell treatments promote faster healing in primates with spinal cord injury

New study shows stem cell treatments promote faster healing in primates with spinal cord injury

A new study appearing today in STEM CELLS Translational Medicine, designed to test how stem cell injections affect primates with spinal cord injury (SCI), showed the treatments significantly improved the animals’ motor function recovery and promoted faster healing, too. The researchers call their findings a step forward toward the goal of improving outcomes for humans with chronic SCI. [More]
Inhibitors BGB324 and BGB10C9 show promise in multiple murine models of pancreatic cancer

Inhibitors BGB324 and BGB10C9 show promise in multiple murine models of pancreatic cancer

BerGenBio AS, an oncology biopharmaceutical company, today announces that an abstract on the latest data on BGB324, the Company's first-in-class, selective small molecule inhibitor of the Axl receptor tyrosine kinase, and BGB10C9, an Axl function-blocking monoclonal antibody in pre-clinical development at BerGenBio, has been published in conjunction with the 2015 American Society of Clinical Oncology Annual Meeting in Chicago, May 29 - June 2, 2015. [More]
21st century trends in management of small renal cancers

21st century trends in management of small renal cancers

A US population-based cohort study reveals a change in the management of small renal masses in the 21st century with rates of nephron-sparing surgery on the rise and a corresponding decrease in the use of radical nephrectomy. [More]
‘Real-world’ sunitinib findings support trial results

‘Real-world’ sunitinib findings support trial results

Results of postmarketing follow-up in Japanese patients confirm the efficacy and safety profile of sunitinib in advanced renal cell carcinoma. [More]
Iron may underlie effect of Alzheimer’s risk allele

Iron may underlie effect of Alzheimer’s risk allele

Ferritin in the cerebrospinal fluid of patients with Alzheimer’s disease is associated with the APOE ε4 risk allele and predicts cognitive outcomes, a study shows. [More]
SNPs predict sunitinib outcome in mRCC

SNPs predict sunitinib outcome in mRCC

Research has confirmed that single nucleotide polymorphisms in genes related to the processing of sunitinib influence the outcome of treatment for metastatic renal cell carcinoma. [More]
Patient characteristics may guide TKI use in CML

Patient characteristics may guide TKI use in CML

The likelihood of complications associated with tyrosine kinase inhibitor therapy in patients with chronic myeloid leukaemia may be reduced by considering patient factors and differences in the toxicity profiles of the different drug options, a review suggests. [More]
High CIP2A may guide TKI choice for chronic phase CML

High CIP2A may guide TKI choice for chronic phase CML

Treatment with a second-generation tyrosine kinase inhibitor prevents progression to blast crisis in chronic myeloid leukaemia patients with high levels of cancerous inhibitor of PP2A, research suggests. [More]
Skin Cancer Awareness Recommended For HCT Recipients

Skin Cancer Awareness Recommended For HCT Recipients

Patients who undergo haematopoietic cell transplantation should be educated on the risk of skin cancer and the need for regular self-examination, US researchers say. [More]
Airway granulocytes potential CF biomarker for fungal lung disease

Airway granulocytes potential CF biomarker for fungal lung disease

Researchers have found that accumulation in the airways of CXCR4+ granulocytes is associated with chronic colonisation by the fungus Aspergillus fumigatus. [More]
Pulmonary rehabilitation ‘should include sleep assessment’

Pulmonary rehabilitation ‘should include sleep assessment’

Researchers say that pulmonary rehabilitation programmes for patients with moderate to severe chronic obstructive pulmonary disease should include sleep assessment. [More]
Challenge remains for early COPD detection in primary care

Challenge remains for early COPD detection in primary care

Exhaled carbon monoxide testing in primary care has no effect on patient acceptance of screening for chronic obstructive pulmonary disease, research shows. [More]
CHOP Global Health Center performs first rigorous study of CP outcomes in Africa

CHOP Global Health Center performs first rigorous study of CP outcomes in Africa

Cerebral palsy (CP) is the most common cause of childhood disability in the world, affecting between 1 and 2 infants per thousand. But the neurological condition tends to be understudied, especially in developing countries. [More]
People with cognitive impairment have altered responses to pain

People with cognitive impairment have altered responses to pain

People with dementia and other forms of cognitive impairment (CI) have altered responses to pain, with many conditions associated with increased pain sensitivity, concludes a research review in PAIN, the official publication of the International Association for the Study of Pain. [More]
Main culprit of Alzheimer's disease causes memory loss

Main culprit of Alzheimer's disease causes memory loss

The study, published May 29 in the open access Nature Publishing Group journal Scientific Reports, reveals a direct link between the main culprit of Alzheimer's disease and memory loss. [More]
Study sheds light on genetic differences between colorectal cancer in older and younger patients

Study sheds light on genetic differences between colorectal cancer in older and younger patients

While the overall rate of colorectal cancer (CRC) is declining, CRC specifically among young patients is increasing. Previous studies have shown that CRC in patients younger than 50 years old tends to be more aggressive than CRC in older patients. [More]
Measuring kidney function and damage may help predict people at risk for heart disease

Measuring kidney function and damage may help predict people at risk for heart disease

Simple measures of kidney function and damage may be just as good at predicting who is at risk for heart failure and death from heart attack and stroke as traditional tests of cholesterol levels and blood pressure, new Johns Hopkins Bloomberg School of Public Health-led research suggests. [More]

First European approval of drug to treat genetic kidney disease ADPKD

Otsuka Pharmaceutical Co., Ltd. announced that the European Commission has granted marketing authorisation for JINARC® (tolvaptan) for the treatment of ADPKD in adults who have chronic kidney disease (CKD) stage one to three at initiation of treatment with evidence of rapidly progressing disease [More]
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