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Study investigates role of miRNAs in anesthetic-induced myocardial conditioning

Many studies have shown that the mechanism of drug-induced myocardial conditioning is enzyme-mediated through messenger RNA and miRNA regulation. In this study Orriach et al. investigated the role that miRNAs play in the cardio-protective effect of halogenated anesthetics, which are widely used in cardiac surgery.

26 Dec 2018

New method of cancer stem cells activation to destroy tumors

This risky method of anti-cancer therapy was suggested by scientists of Far Eastern Federal University (FEFU). Their review of mechanisms for molecular activation of stem cells of gliomas (most widely-spread brain tumors) was approved for publishing in the Frontiers in Cellular Neuroscience journal.

26 Dec 2018

New mechanism may explain neurons shrinking in Huntington's disease

A hallmark of neurodegenerative diseases like Huntington's is the progressive death of nerve cells in the brain. The cells don't die quickly, though. They first start to disconnect from each other because their neurites -- long finger-like extensions that make connections all through the brain -- become smaller.

25 Dec 2018

Brain activity found to be predictive of pain-related fear

Researchers applied a machine learning technique that could potentially translate patterns of activity in fear-processing brain regions into scores on questionnaires used to assess a patient's fear of pain. This neuroscientific approach, reported in eNeuro, may help reconcile self-reported emotions and their neural underpinnings.

25 Dec 2018

Neuroimaging study explores how socioeconomic status shapes developing brains

The relationship between socioeconomic status and brain anatomy is mostly stable from childhood to early adulthood, according to a longitudinal neuroimaging study of more than 600 healthy young people published in JNeurosci.

25 Dec 2018

Study reveals side effects of breast cancer drug on brain function

A comprehensive study of monkeys given the breast cancer drug letrozole reveals side effects that impact the brain. Published in JNeurosci, the research establishes the common marmoset as an important nonhuman primate model for studying the effects of estrogen-reducing treatments on the nervous system.

25 Dec 2018

The role of galanin-like peptide in regulating feeding behavior and energy metabolism

Galanin-like peptide is a short peptide made up of 60 amino acid residues. This sequence is homologous across several species. The hypothalamic arcuate nucleus is the place where GALP is produced. GALP has diverse physiological effects such as the regulation of feeding, energy metabolism, and reproductive behavior.

25 Dec 2018

Critically ill children experience muscle atrophy within one week of mechanical ventilation

Children with life-threatening respiratory failure who require mechanical ventilation in a pediatric intensive care unit commonly experience rapid muscle atrophy, according to a study published online Dec. 19, 2018, in PLOS ONE.

24 Dec 2018

Study shows paramedics can safely assess psychiatric patients’ medical condition in the field

Emergency medical personnel in Alameda County, California, use a screening process for determining whether to "medically clear" patients experiencing psychiatric emergencies before transporting them.

24 Dec 2018

Scientists discover two therapies that slow progression of pediatric leukemia in mice

Northwestern Medicine scientists have discovered two successful therapies that slowed the progression of pediatric leukemia in mice, according to three studies published over the last two years in the journal Cell, and the final paper published Dec. 20 in Genes & Development.

24 Dec 2018

Study: Overlapping surgery is safe for patients undergoing outpatient orthopedic procedures

At least for brief periods, overlapping surgery is safe for patients undergoing outpatient or "same-day" orthopedic surgery procedures, reports a study in the December 19, 2018 issue of The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.

24 Dec 2018

Simple tests in GP surgeries could increase diagnosis rate of liver disease

Research carried out by scientists at the University of Southampton has shown that simple tests in GP surgeries could potentially double the diagnosis rate of liver disease where patients are not displaying any symptoms.

24 Dec 2018

Kidney patients have the highest number of comorbidities, shows study

A study published in JAMA Network Open showed: nephrologists treat the most complex patients. As ERA-EDTA president Professor Carmine Zoccali explains, kidney patients are highly vulnerable and need special care, but nephrology is a neglected discipline in many European healthcare systems.

24 Dec 2018

Researchers report uncertainty around long-term effectiveness of medications to control knee osteoarthritis pain

Managing osteoarthritis requires long-term treatment for symptoms such as pain and changes in joint structure that can lead to disability.

24 Dec 2018

The impact of maternal diabetes on fetal heart development

Congenital heart disease is the most common birth defect. And even with remarkable advances in care, it remains the leading cause of non-infectious death in infants.

24 Dec 2018

Whole genome study identifies genetic architecture for diagnosis of polycystic ovary syndrome

In the largest genetic analysis of polycystic ovary syndrome (PCOS) performed to date, an international consortium, including researchers at the Icahn School of Medicine at Mount Sinai, conducted a whole genome association study to identify common genetic architecture for different diagnostic criteria used to define the syndrome.

24 Dec 2018

CWRU researcher receives nearly $1 million to study drug resistance mechanisms in prostate cancer

Sanjay Gupta, PhD, of Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center will receive $962,000 over three years to investigate drug resistance mechanisms in prostate cancer.

24 Dec 2018

Researchers compare scheduled vs. emergency-only dialysis among undocumented immigrants

A unique opportunity made it feasible for uninsured patients with end-stage renal disease (ESRD) who received emergency-only dialysis in Dallas, Texas, to enroll in private, commercial health insurance plans in 2015 and that made it possible for researchers to compare scheduled vs. emergency-only dialysis among undocumented immigrants with ESRD.

24 Dec 2018

Glial cell maturation is severely impaired in patients with Huntington's disease

The neurological disorder Huntington's disease causes behavioral and motor changes, which among other things are a result of dysfunctional maturation or formation of glial cells, the brain's support cells, researchers from the University of Copenhagen demonstrate in a new study based on mice trials.

24 Dec 2018

Risk of heart attack and stroke is high in the months before cancer diagnosis, shows study

Older adults with cancer are more likely to have had a heart attack or stroke in the months prior to their cancer diagnosis compared with similar adults who do not have cancer during the same period, according to a report published online today in Blood. Lung and colon cancers, as well as advanced-staged cancers, appear to be most strongly associated with an elevated risk of heart attack and stroke caused by blood clots in the arteries.

24 Dec 2018

Medical Research News

Study investigates role of miRNAs in anesthetic-induced myocardial conditioning

New method of cancer stem cells activation to destroy tumors

New mechanism may explain neurons shrinking in Huntington's disease

Brain activity found to be predictive of pain-related fear

Neuroimaging study explores how socioeconomic status shapes developing brains

Study reveals side effects of breast cancer drug on brain function

The role of galanin-like peptide in regulating feeding behavior and energy metabolism

Critically ill children experience muscle atrophy within one week of mechanical ventilation

Study shows paramedics can safely assess psychiatric patients’ medical condition in the field

Scientists discover two therapies that slow progression of pediatric leukemia in mice

Study: Overlapping surgery is safe for patients undergoing outpatient orthopedic procedures

Simple tests in GP surgeries could increase diagnosis rate of liver disease

Kidney patients have the highest number of comorbidities, shows study

Researchers report uncertainty around long-term effectiveness of medications to control knee osteoarthritis pain

The impact of maternal diabetes on fetal heart development

Whole genome study identifies genetic architecture for diagnosis of polycystic ovary syndrome

CWRU researcher receives nearly $1 million to study drug resistance mechanisms in prostate cancer

Researchers compare scheduled vs. emergency-only dialysis among undocumented immigrants

Glial cell maturation is severely impaired in patients with Huntington's disease

Risk of heart attack and stroke is high in the months before cancer diagnosis, shows study

Advancing brain microphysiological systems (bMPS)

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

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