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Study discovers microRNA signatures that could predict prognosis, distant metastasis in colorectal cancer

Study discovers microRNA signatures that could predict prognosis, distant metastasis in colorectal cancer

A new study developed at the Center for Gastrointestinal Cancer Research and the Center for Epigenetics, Cancer Prevention and Cancer Genomics at Baylor Research Institute has discovered unique metastasis-specific microRNA signatures in primary colorectal cancers that could predict prognosis and distant metastasis in colorectal cancer. [More]
NEB announces introduction of one-step cloning and multiple DNA fragment assembly

NEB announces introduction of one-step cloning and multiple DNA fragment assembly

New England Biolabs announces the introduction of the NEBuilder HiFi DNA Assembly Cloning Kit and Master Mix for one-step cloning and multiple DNA fragment assembly in as little as 15 minutes. [More]
NR2F1 gene: A 'master regulator' of tumor cell growth

NR2F1 gene: A 'master regulator' of tumor cell growth

Two existing cancer drugs turn on a gene that tells tumor cells to remain inactive, according to a study led by researchers at the Icahn School of Medicine at Mount Sinai and published today in Nature Communications. [More]
Researchers reveal why many African-American women are diagnosed with deadly forms of breast cancer

Researchers reveal why many African-American women are diagnosed with deadly forms of breast cancer

Researchers have uncovered new information that may begin to explain why many African-American women are more likely to be diagnosed with aggressive, often deadly forms of breast cancer, which strengthens the evidence that increased dietary folate intake may prove to be an effective strategy for reducing risk for the disease in African-American women. [More]
Corn oil has greater effects on blood cholesterol than extra virgin olive oil

Corn oil has greater effects on blood cholesterol than extra virgin olive oil

A study published in the January/February 2015 issue of the Journal of Clinical Lipidology indicates corn oil significantly reduces cholesterol more than extra virgin olive oil with favorable changes in both total and low-density lipoprotein (LDL) cholesterol. [More]
Some genetic features associated with modern diseases are ancient

Some genetic features associated with modern diseases are ancient

Psoriasis, a chronic skin condition, can cause rashes that itch and sting. So why would a genetic susceptibility to this and other ailments persist for hundreds of thousands of years, afflicting our ancient ancestors, and us? [More]
Study reveals how the brain can use fatty acids to control liver lipid production

Study reveals how the brain can use fatty acids to control liver lipid production

Ways of keeping the heart healthy has widened, with the discovery that the brain can help fight off hardening of the arteries. [More]
Emory researchers complete detailed maps of 184 duplications found in genomes

Emory researchers complete detailed maps of 184 duplications found in genomes

Copy number variations (deletions or duplications of large chunks of the genome) are a major cause of birth defects, intellectual disability, autism spectrum disorder and other developmental disorders. Still, geneticists can definitively say how a CNV, once discovered in someone's DNA, leads to one of these conditions in just a fraction of cases. [More]
Altered dopamine signaling may contribute to autism

Altered dopamine signaling may contribute to autism

Newly discovered genetic variations linked to autism spectrum disorder (ASD) disrupt the function of the dopamine transporter, suggesting that altered dopamine signaling contributes to this common developmental condition, according to a Vanderbilt University-led research team. [More]
Scientists identify biological clock that can help predict individual's age

Scientists identify biological clock that can help predict individual's age

Scientists have identified a biological clock that provides vital clues about how long a person is likely to live. [More]
TSRI researchers awarded grant to develop novel method for detecting DNA damage in stem cells

TSRI researchers awarded grant to develop novel method for detecting DNA damage in stem cells

A team at The Scripps Research Institute has won a $1,784,000 grant from the California Institute for Regenerative Medicine (CIRM). The funding will support the development of a new method for detecting DNA damage in stem cells to ensure that only the highest quality cells are used in transplantation or therapy. [More]
Two researchers receive Charles Rodolphe Brupbacher Prize for Cancer Research

Two researchers receive Charles Rodolphe Brupbacher Prize for Cancer Research

Researchers Irving L. Weissman and Joan Massagué have won this year's Charles Rodolphe Brupbacher Prize for Cancer Research: Weissman, from Stanford University, for his work on healthy and sick stem cells; Massagué, from Memorial Sloan Kettering Cancer Center in New York, for his research on metastatic spread. [More]
Inhibition of SIRT1 protein may hold promise for treatment of metastatic Ewing sarcoma

Inhibition of SIRT1 protein may hold promise for treatment of metastatic Ewing sarcoma

Researchers at the Bellvitge Biomedical Research Institute (IDIBELL), led by Oscar Martínez Tirado participated in an international study which suggests inhibition of Sirtuin1 (SIRT1) protein as a future treatment option for metastatic Ewing sarcoma. The results of the study were published in the journal Cancer Research. [More]
Damon Runyon Cancer Research Foundation names 15 new Damon Runyon Fellows

Damon Runyon Cancer Research Foundation names 15 new Damon Runyon Fellows

The Damon Runyon Cancer Research Foundation, a non-profit organization focused on supporting innovative early career researchers, named 15 new Damon Runyon Fellows at its fall Fellowship Award Committee review. The recipients of this prestigious, four-year award are outstanding postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators across the country. [More]
Nanoscale DNA tool to detect molecular behavior

Nanoscale DNA tool to detect molecular behavior

A complex interplay of molecular components governs almost all aspects of biological sciences - healthy organism development, disease progression, and drug efficacy are all dependent on the way life's molecules interact in the body. Understanding these bio-molecular interactions is critical for the discovery of new, more effective therapeutics and diagnostics to treat cancer and other diseases, but currently requires scientists to have access to expensive and elaborate laboratory equipment. [More]
Multiplexed testing for EGFR and ALK gene rearrangements may be cost-effective for NSCLC treatment

Multiplexed testing for EGFR and ALK gene rearrangements may be cost-effective for NSCLC treatment

Multiplexed genetic screening for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) gene rearrangements and subsequent biomarker-guided treatment is cost-effective compared with standard chemotherapy treatment without any molecular testing in the metastatic non-small cell lung cancer (NSCLC) setting in the United States. [More]
FDA’s approval of ibrutinib to treat Waldenstrom's macroglobulinemia receives praises from LLS

FDA’s approval of ibrutinib to treat Waldenstrom's macroglobulinemia receives praises from LLS

The U.S. Food and Drug Administration approval of ibrutinib (Imbruvica) to treat patients with Waldenstrom's macroglobulinemia(WM) is a significant advance for patients with this rare blood cancer. [More]
Scientists reveal mechanism underlying cellular degeneration of upper motor neurons

Scientists reveal mechanism underlying cellular degeneration of upper motor neurons

For the first time, scientists have revealed a mechanism underlying the cellular degeneration of upper motor neurons, a small group of neurons in the brain recently shown to play a major role in ALS pathology. [More]
TCGA researchers uncover differences between tumors with and without HPV infection

TCGA researchers uncover differences between tumors with and without HPV infection

The study by The Cancer Genome Atlas (TCGA) researchers analyzed the genomes of 279 head and neck cancer tumors. They identified subtypes of head and neck cancer based on their genomic characteristics, changes in smoking-related tumors, as well as genomic differences in head and neck cancer tumors linked to HPV, the most commonly sexually transmitted disease in the United States. [More]
TAU researchers identify novel proteins capable of stymieing growth in antibiotic-resistant bacteria

TAU researchers identify novel proteins capable of stymieing growth in antibiotic-resistant bacteria

Antibiotic-resistant infections are on the rise, foiling efforts to reduce death rates in developing countries where uncontrolled use of antibiotics and poor sanitation run amok. The epidemic of "superbugs," bacteria resistant to antibiotics, knows no borders -- presenting a clear and present danger around the globe. [More]