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Researchers successfully use alcohols as reagents in alkylation reaction

Researchers successfully use alcohols as reagents in alkylation reaction

Researchers at Princeton have developed a dual catalyst system that directly installs alkyl groups--fragments containing singly bonded carbon and hydrogen atoms that have extremely useful properties for drug discovery--onto compounds called heteroarenes. The new reaction uses simple and abundant alcohols and offers a milder and more widely applicable alternative to existing strategies. [More]
Cell-to-cell transmission of HIV leads to development of AIDS

Cell-to-cell transmission of HIV leads to development of AIDS

Researchers from the Gladstone Institutes have revealed that HIV does not cause AIDS by the virus's direct effect on the host's immune cells, but rather through the cells' lethal influence on one another. [More]
UVA researchers reveal how sperm use 'harpoon' to facilitate fertilization

UVA researchers reveal how sperm use 'harpoon' to facilitate fertilization

Could the sperm harpoon the egg to facilitate fertilization? That's the intriguing possibility raised by the University of Virginia School of Medicine's discovery that a protein within the head of the sperm forms spiky filaments, suggesting that these tiny filaments may lash together the sperm and its target. [More]
Scientists uncover mechanism responsible for development of adrenal gland tumors

Scientists uncover mechanism responsible for development of adrenal gland tumors

Scientists at the Helmholtz Zentrum München have elucidated a mechanism that is responsible for the development of adrenal gland tumors. They discovered that the BMP7 protein plays a key role in this process and that it could be a possible target for future treatments. The results have been published in the journal 'Oncotarget'. [More]
Researchers identify drugs that may enhance ability of TKI dasatinib to kill human cancer cells

Researchers identify drugs that may enhance ability of TKI dasatinib to kill human cancer cells

Researchers have discovered how a common mutation in a high-risk leukemia subtype drives the cancer's aggressiveness and have identified drugs that may work with existing precision medicines to improve survival. St. Jude Children's Research Hospital scientists led the study, which was published online today in the journal Cancer Cell. [More]
Researchers identify druggable target to potentially root out colon cancer, end relapse

Researchers identify druggable target to potentially root out colon cancer, end relapse

Researchers targeting colorectal cancer stem cells - the root cause of disease, resistance to treatment and relapse - have discovered a mechanism to mimic a virus and potentially trigger an immune response to fight the cancer like an infection. [More]
Pitt researchers identify molecular mechanisms behind resilience to tinnitus, possible drug therapy

Pitt researchers identify molecular mechanisms behind resilience to tinnitus, possible drug therapy

Researchers have identified in an animal model the molecular mechanisms behind resilience to noise-induced tinnitus and a possible drug therapy that could reduce susceptibility to this chronic and sometimes debilitating condition. The findings by a team from the University of Pittsburgh School of Medicine were published online in the journal eLife. [More]
Researchers find fatty acid deposits in brains of Alzheimer's patients

Researchers find fatty acid deposits in brains of Alzheimer's patients

People with Alzheimer's disease have fat deposits in the brain. For the first time since the disease was described 109 years ago, researchers affiliated with the University of Montreal Hospital Research Centre (CRCHUM) have discovered accumulations of fat droplets in the brain of patients who died from the disease and have identified the nature of the fat. [More]
Adaptive immune system plays active role in guiding development of mammary glands

Adaptive immune system plays active role in guiding development of mammary glands

In experiments with mouse tissue, UC San Francisco researchers have discovered that the adaptive immune system, generally associated with fighting bacterial and viral infections, plays an active role in guiding the normal development of mammary glands, the only organs--in female humans as well as mice--that develop predominately after birth, beginning at puberty. [More]
New review article reveals Y chromosome’s role in cardiovascular and immune function, cancer

New review article reveals Y chromosome’s role in cardiovascular and immune function, cancer

The role of sex in human disease is a growing area of research. Although estrogen (in females) and androgens (in males) are often seen as possible causes for such differences, sex chromosomes, including the male-specific Y chromosome, may also play a role. However, it has been difficult to understand how the Y chromosome could contribute to disease in men, in part because it is much more difficult to sequence than all other chromosomes. [More]
Researchers uncover important cellular functions that help regulate inflammation

Researchers uncover important cellular functions that help regulate inflammation

Researchers at the Virginia Bioinformatics Institute at Virginia Tech have uncovered key cellular functions that help regulate inflammation -- a discovery that could have important implications for the treatment of allergies, heart disease, and certain forms of cancer. [More]
Brain cells in Parkinson's disease die prematurely, burning out like an overheating motor

Brain cells in Parkinson's disease die prematurely, burning out like an overheating motor

The death of brain cells in Parkinson's disease may be caused by a form of cellular energy crisis in neurons that require unusually high quantities of energy to carry out their job of regulating movement, researchers at the University of Montreal reported today. [More]
Melatonin hormone can help prevent cardiovascular disease risk in children born through ART

Melatonin hormone can help prevent cardiovascular disease risk in children born through ART

Studies are revealing that children born through assisted reproductive technologies (ART) have a higher risk of developing cardiovascular disease. The increased risk is due to changes in the expression of the genes important for vascular health. These studies suggest that the composition of the solutions in which embryo fertilization and culturing are done is to blame. [More]
Research with UWF imaging may change how diabetic eye disease is assessed and treated

Research with UWF imaging may change how diabetic eye disease is assessed and treated

For decades, clinicians have detected and monitored diabetic eye disease with standard retinal photographs that cover about a third of the retina. In recent years, an emerging class of ultrawide field (UWF) cameras has given a substantially larger view of the retina, providing new insight on the presentation and natural history of retinal disease. [More]
Special issue of Future Science OA highlights research on protein misfolding diseases

Special issue of Future Science OA highlights research on protein misfolding diseases

Future Science Group today announced the publication of a special issue in Future Science OA, covering the rapidly evolving field of protein misfolding diseases. [More]
Scientists generate pluripotent stem cells with more stable genomes

Scientists generate pluripotent stem cells with more stable genomes

Damaged tissue, such as pancreas, heart, and neuronal tissue, which is regenerated to treat cardiovascular diseases, diabetes, or neurodegenerative diseases. This is one of the ambitious scenarios to which regenerative medicine aspires and that is being announced as one of the great promises of twenty-first century biomedicine for the treatment of a long list of diseases affecting people today. [More]
Discovery could open up door for cancer research and treatment

Discovery could open up door for cancer research and treatment

Florida State University researchers have taken a big step forward in the fight against cancer with a discovery that could open up the door for new research and treatment options. [More]
Probiotics show no benefit in preventing gastrointestinal colonization with drug-resistant microbes in ICU patients

Probiotics show no benefit in preventing gastrointestinal colonization with drug-resistant microbes in ICU patients

Compared with routine medical care, probiotics administered to critically ill patients in intensive care units showed no benefit in preventing the colonization of drug-resistant microbes in the intestinal tract, according to new research at Washington University School of Medicine in St. Louis. [More]

Brainbow technique reveals surprising data about brain's visual circuitry

Neuroscientists know that some connections in the brain are pruned through neural development. Function gives rise to structure, according to the textbooks. But scientists at the Virginia Tech Carilion Research Institute have discovered that the textbooks might be wrong. [More]
Experimental gene therapy may prevent neuronal degeneration in patients with Alzheimer's disease

Experimental gene therapy may prevent neuronal degeneration in patients with Alzheimer's disease

Degenerating neurons in patients with Alzheimer's disease (AD) measurably responded to an experimental gene therapy in which nerve growth factor (NGF) was injected into their brains, report researchers at University of California, San Diego School of Medicine in the current issue of JAMA Neurology. [More]
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