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Scientists devise new route to synthesize insecticide in 15 steps

Scientists devise new route to synthesize insecticide in 15 steps

For chemists like Sarah Reisman, professor of chemistry at Caltech, synthesizing molecules is like designing your own jigsaw puzzle. You know what the solved puzzle looks like--the molecule--and your job is to figure out the best pieces to use to put it together. [More]
Researchers explore molecular mechanisms through which lead exposure may affect neural stem cells

Researchers explore molecular mechanisms through which lead exposure may affect neural stem cells

Researchers have identified a potential molecular mechanism through which lead, a pervasive environmental toxin, may harm neural stem cells and neurodevelopment in children. [More]
Researchers find new way for early prediction of leukemic relapse

Researchers find new way for early prediction of leukemic relapse

Researchers at University of California San Diego School of Medicine and Moores Cancer Center have identified RNA-based biomarkers that distinguish between normal, aging hematopoietic stem cells and leukemia stem cells associated with secondary acute myeloid leukemia (sAML), a particularly problematic disease that typically afflicts older patients who have often already experienced a bout with cancer. [More]
Researchers engineer protein-shelled nanostructures useful for ultrasound imaging

Researchers engineer protein-shelled nanostructures useful for ultrasound imaging

Ultrasound imaging is used around the world to help visualize developing babies and diagnose diseases. Sound waves bounce off the tissues, revealing their different densities and shapes. [More]
Hitchhiking of drugs on incorrect targets can cause adverse side effects

Hitchhiking of drugs on incorrect targets can cause adverse side effects

It probably isn't surprising to read that pharmaceutical drugs don't always do what they're supposed to. Adverse side effects are a well-known phenomenon and something many of us will have experienced when taking medicines. [More]
Kobe University researchers develop new technique for high-level genome editing operation

Kobe University researchers develop new technique for high-level genome editing operation

A team involving Kobe University researchers has succeeded in developing 'Target-AID', a genome editing technique that does not cleave the DNA. [More]
IRB Barcelona review article provides insights into emerging field of shuttle peptides

IRB Barcelona review article provides insights into emerging field of shuttle peptides

IRB Barcelona researchers publish a review article on the emerging field of drug transporters that have the capacity to reach the brain more efficiently. [More]
Novel inhibitory brain receptor reduces seizure-like activity in pubertal mice

Novel inhibitory brain receptor reduces seizure-like activity in pubertal mice

More than half of children with epilepsy outgrow their seizures, yet the mechanism underlying this remission is unknown. [More]
Novel small-molecule Wnt inhibitor may provide new treatment option for colorectal cancer patients

Novel small-molecule Wnt inhibitor may provide new treatment option for colorectal cancer patients

A team including the National Cancer Center, the RIKEN Center for Life Science Technologies , and Carna Biosciences Inc., has jointly announced the development of a novel small-molecule Wnt inhibitor named NCB-0846. [More]
NIPS researchers reveal new mechanisms by which microglia sculpt neural circuits

NIPS researchers reveal new mechanisms by which microglia sculpt neural circuits

Microglia are cells that combat various brain diseases and injuries by swallowing foreign or disruptive objects and releasing molecules that activate repair mechanisms. [More]
Chromatrap develops new range of optimised ChIP assay kits for genetic research

Chromatrap develops new range of optimised ChIP assay kits for genetic research

Chromatrap is a pioneer in the development of solid-state filter-based technology that significantly enhances and accelerates the important epigenetic research tool of chromatin immunoprecipitation (ChIP). [More]
Study finds age-dependent differences in expression of allergy to dust mites

Study finds age-dependent differences in expression of allergy to dust mites

In adults with a house dust mite allergy, a cascade of inflammatory signals on the surface of the airways leads to airway remodeling. [More]
New report documents fetal brain abnormalities linked to congenital Zika infection

New report documents fetal brain abnormalities linked to congenital Zika infection

In a special report released August 23 in the journal Radiology, a team of researchers including Deborah Levine, MD, Director of Obstetric & Gynecologic ultrasound at Beth Israel Deaconess Medical Center and professor of radiology at Harvard Medical School, documented the brain abnormalities associated with congenital Zika in 45 confirmed and presumed cases from northeastern Brazil. [More]
TSRI study sheds light on how mitochondrial calcium can affect learning and memory

TSRI study sheds light on how mitochondrial calcium can affect learning and memory

While calcium's importance for our bones and teeth is well known, its role in neurons—in particular, its effects on processes such as learning and memory—has been less well defined. [More]
Stiff arteries can negatively impact memory and vital brain processes

Stiff arteries can negatively impact memory and vital brain processes

As we age, our arteries gradually become less flexible, making it harder for the heart to pump blood throughout the body. [More]
Researchers show how cannabinoids affect vision

Researchers show how cannabinoids affect vision

A multidisciplinary team including researchers from the Montreal Neurological Institute has improved our understanding of how cannabinoids, the active agent in marijuana, affect vision in vertebrates. [More]
Study reveals how pluripotency differs among mice, monkeys, and humans

Study reveals how pluripotency differs among mice, monkeys, and humans

Not too shabby, humans. New research shows that certain primate stem cells have pluripotency superior to some types derived from mice. [More]
Scientists isolate new multicomponent virus from mosquitoes

Scientists isolate new multicomponent virus from mosquitoes

Scientists have identified a new "multicomponent" virus -- one containing different segments of genetic material in separate particles -- that can infect animals, according to research published today in the journal Cell Host & Microbe. [More]
New biomaterial allows scientists to study how stem cells sense stiffness of surrounding environment

New biomaterial allows scientists to study how stem cells sense stiffness of surrounding environment

A new biomaterial can be used to study how and when stem cells sense the mechanics of their surrounding environment, found a team led by Robert Mauck, PhD, the Mary Black Ralston Professor for Education and Research in Orthopaedic Surgery, in the Perelman School of Medicine at the University of Pennsylvania. [More]
Researchers develop new method to culture norovirus in intestinal cells

Researchers develop new method to culture norovirus in intestinal cells

Researchers have succeeded in culturing norovirus in human intestinal cells, a breakthrough that could help scientists develop novel therapeutics and vaccines against the debilitating effects of the virus. [More]
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