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Researchers use engineered proteins to record histories of cellular events

As cells perform their everyday functions, they turn on a variety of genes and cellular pathways. MIT engineers have now coaxed cells to inscribe the history of these events in a long protein chain that can be imaged using a light microscope.

2 Jan 2023

New method records gene activity patterns and presence of proteins across tissues

A new method can illuminate the identities and activities of cells throughout an organ or a tumor at unprecedented resolution, according to a study co-led by researchers at Weill Cornell Medicine, NewYork-Presbyterian and the New York Genome Center.

2 Jan 2023

Novel approach may prevent antibodies from triggering immune rejection of transplant cells

Researchers at UCSF have developed a novel, potentially life-saving approach that may prevent antibodies from triggering immune rejection of engineered therapeutic and transplant cells.

2 Jan 2023

Novel experimental approach slows physical decline and extends the lives of roundworms

Scientists in aging research today report a novel experimental approach that slowed the rate of physical decline and lengthened the lives of roundworms commonly used in biological studies, C. elgans.

30 Dec 2022

DNAm measures of biological aging linked with neuropsychologically-validated cognitive decline in midlife

A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 14, Issue 23, entitled, "DNA methylation-based measures of biological aging and cognitive decline over 16-years: preliminary longitudinal findings in midlife."

30 Dec 2022

New insights on the circadian clock of Drosophila melanogaster

The higher the temperatures, the faster physiological processes are. But there is an exception: the so-called circadian clock, which regulates the sleep-wake cycle in organisms.

30 Dec 2022

Study reveals novel role of PPARγ acetylation in macrophages in impairing adipose tissue function

As a chronic pro-inflammatory disease, obesity is closely associated with the development of various diseases such as type 2 diabetes, cardiovascular disease and cancers. Obesity is now a major concern for public health.

30 Dec 2022

New insights into how working memory information may be held in mind

Between the time you read the Wi-Fi password off the café's menu board and the time you can get back to your laptop to enter it, you have to hold it in mind.

29 Dec 2022

Human cortical organoids implanted in mice establish functional connectivity and respond to sensory stimuli

A team of engineers and neuroscientists has demonstrated for the first time that human brain organoids implanted in mice have established functional connectivity to the animals' cortex and responded to external sensory stimuli.

29 Dec 2022

Study investigates a new mechanism of pyrethroid derivatives-moderated programmed cell death

A new research paper was published in Oncotarget's Volume 13 on December 17, 2022, entitled, "The role of pyrethroid derivatives in autophagy and apoptosis crosstalk signaling and potential risk for malignancies."

29 Dec 2022

Unraveling the biology of senescent cells and healthy aging

Multiple researchers at the Jackson Laboratory are taking part in an ambitious research program spanning several top research institutions to study senescent cells.

29 Dec 2022

Researchers unravel how cells use their sense of touch to make decisions during embryogenesis

A research team at the Cluster of Excellence Physics of Life of TU Dresden and the University of California, Santa Barbara, reveals how cells sense their mechanical environment as they build tissues during embryogenesis.

28 Dec 2022

Enzyme that defends human cells against viruses may be a potential target for future cancer treatments

An enzyme that defends human cells against viruses can help drive cancer evolution towards greater malignancy by causing myriad mutations in cancer cells, according to a study led by investigators at Weill Cornell Medicine.

28 Dec 2022

New mathematical model for the motion of bacteria

Biofilms form when microorganisms such as certain types of bacteria adhere to the surface of objects in a moist environment and begin to reproduce resulting in the excretion of a slimy glue-like substance.

28 Dec 2022

Study reveals a previously unappreciated complexity of TRM cell biology in the gut

Recent pressure to maximize vaccine efficacy has stirred up many new discoveries within immunology, revealing numerous paradigms with untapped therapeutic potential.

28 Dec 2022

Alveolar macrophages present as antigens to promote virus-specific CD8+ T cell expansion

The human immune system is a highly complex network of cells, signals, and responses that is tightly regulated to ensure that the body can fight off infection without damaging its own tissues.

28 Dec 2022

Virus-only diet can fuel the physiological and population growth of an organism

Over a single day, in the placid waters of a single pond, a million virus particles might enter a single-celled organism known for the minuscule hairs, or cilia, that propel it through those waters.

27 Dec 2022

Insilico announces nomination of preclinical candidate targeting KAT6A for ER+/HER2- breast cancer therapy

Insilico Medicine ("Insilico"), a clinical-stage end-to-end artificial intelligence (AI)-driven drug discovery company, today announced that the company's drug discovery team has nominated a preclinical candidate targeting KAT6A for ER+/HER2- breast cancer therapy utilizing its end-to-end Pharma.AI platform.

27 Dec 2022

Xanthan gum-based fluid thickener can lower blood glucose levels after eating, study shows

Type 2 diabetes mellitus is a common lifestyle disease that is prevalent worldwide. It can often lead to complications, such as diseases of the heart, and increased risk of death, but preventive measures, such as a healthy diet, can reduce these risks.

27 Dec 2022

Checkerboard-like arrangement of inner ear cells vital for hearing, research reveals

A Japanese research group has become the first to reveal that the checkerboard-like arrangement of cells in the inner ear's organ of Corti is vital for hearing.

27 Dec 2022

Life Science News

Researchers use engineered proteins to record histories of cellular events

New method records gene activity patterns and presence of proteins across tissues

Novel approach may prevent antibodies from triggering immune rejection of transplant cells

Novel experimental approach slows physical decline and extends the lives of roundworms

DNAm measures of biological aging linked with neuropsychologically-validated cognitive decline in midlife

New insights on the circadian clock of Drosophila melanogaster

Study reveals novel role of PPARγ acetylation in macrophages in impairing adipose tissue function

New insights into how working memory information may be held in mind

Human cortical organoids implanted in mice establish functional connectivity and respond to sensory stimuli

Study investigates a new mechanism of pyrethroid derivatives-moderated programmed cell death

Unraveling the biology of senescent cells and healthy aging

Researchers unravel how cells use their sense of touch to make decisions during embryogenesis

Enzyme that defends human cells against viruses may be a potential target for future cancer treatments

New mathematical model for the motion of bacteria

Study reveals a previously unappreciated complexity of TRM cell biology in the gut

Alveolar macrophages present as antigens to promote virus-specific CD8+ T cell expansion

Virus-only diet can fuel the physiological and population growth of an organism

Insilico announces nomination of preclinical candidate targeting KAT6A for ER+/HER2- breast cancer therapy

Xanthan gum-based fluid thickener can lower blood glucose levels after eating, study shows

Checkerboard-like arrangement of inner ear cells vital for hearing, research reveals

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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