Life Science White Papers

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Life Science White Papers are in-depth articles aimed to educate and inform site visitors interested in life science research. Some of these papers are derived from sources where we have existing commercial relationships. Such articles are clearly labelled as sponsored content and are only accepted when the content is deemed to add value to the core editorial ethos of News Medical.

Importance of Spectral Quality in Spectroscopy and Disinfection Applications

In UVC LEDs, the term “spectral quality” has different implications based on the application. For instance, a narrow peak without secondary peaks is usually favored in spectroscopy, while the total energy within the UVC peak can be utilized to neutralize microorganisms for disinfection purposes.

From Crystal IS, Inc. 30 Nov 2014

Analysis of Pharmaceutical Particles Using Phenom desktop Scanning Electron Microscope

The Phenom is an advanced, tabletop scanning electron microscope (SEM) offering sophisticated sample navigation functions and intuitive touch-screen controls. The microscope can be used to achieve magnifications of up to 100,000x and fast and accurate X-ray EDS analsys.

From Thermo Fisher Scientific Phenom-World BV 18 Nov 2014

Changes to ISO 14644-1 Standard Improves Confidence in Cleanroom Performance for Critical Life-Science Applications

As part of the ISO periodic review cycle, ISO 14644-1, Cleanrooms and associated controlled environments — Classification of air cleanliness is being revised.

From Beckman Coulter Life Sciences - Particle Counting and Characterization 13 Nov 2014

Using MET ONE HHPC 6+ Particle Counter for Classification of Clean Room

MET ONE Instruments’ HHPC 6+ handheld particle counter is used to classify an ISO Class 5 clean room and the related ISO Class 7 gowning room.

From Beckman Coulter Life Sciences - Particle Counting and Characterization 11 Nov 2014

Comparison of Instrument-to-Instrument Variability Using Vi-CELL Automated Cell Viability Analyzer

This article recommends best practices to reduce instrument-to-instrument variability for Beckman Coulter’s Vi-CELL automated cell viability analyzer and also shows what degree of variability can be anticipated in almost ideal conditions.

From Beckman Coulter Life Sciences - Particle Counting and Characterization 9 Nov 2014

Automated Measurements of Whole Blood and White Blood Cell Viability Using Beckman Coulter Reagents

The Vi-CELL™ cell viability analyzer is capable of automated measurements and consequently eliminates the biased nature of the standard white blood cell (WBC) counting process

From Beckman Coulter Life Sciences - Particle Counting and Characterization 9 Nov 2014

Using Automated Cell Counters for Seasonal Comparison of Cells

Mammalian cell culture is the initial starting point in the procedures used for much of today’s biomedical research and it is important to preserve healthy cells if subsequent experiments are going to be effective.

From Logos Biosystems 14 Oct 2014

Applications of KSV NIMA Analytical Instruments in Studying Biomolecular Interactions in Cell Membrane Models

The majority of biochemical reactions occur at the phospholipid bilayer membrane, either on or within cells. These membranes affect how proteins fold as well as creating particular microenvironments where the reactions can occur. In order to emulate real biological systems, interactions should be explored in environments that mimic nature as closely as possible. This article shows how KSV NIMA’s analytical systems can be used to produce models of cell membranes and examine the biomolecular interactions that occur.

From Biolin Scientific AB 5 Oct 2014

Using QCM-D Technique to Improve Drug Research and Development

Quartz crystal microbalance with dissipation (QCM-D) is an advanced technique that enables real-time screening of protein drug targets and cellular compound interactions. The QCM-D technique is unique in its ability to sense changes in energy dissipation (softness) and can be used to detect both structural and conformational changes in whole cells and molecular layers.

From Biolin Scientific AB 5 Oct 2014

Imaging and Biosimulation Platform to Advance Drug Discovery and Development for CNS Diseases

The Québec Consortium for Drug Discovery (CQDM), OSÉO and Alsace-Biovalley have jointly funded a project called the Imaging and biosimulation platform for new central nervous system drugs (BICNSD).

From Photon etc. 8 Sep 2014

Application of ASTRA 6 Software Tool for Analysis of Drug-Antibody Components

Antibody-drug conjugates (ADCs) are a new type of drug that are currently the subject of much interest due to their potential application in the targeted delivery of cancer treatments. One of the key factors in the effective design of ADCs is the Drug Antibody Ratio (DAR).

From Waters | Wyatt Technology 2 Aug 2014

Nanoparticle and Macromolecular Analysis using the DynaPro DLS Plate Reader

In immunoglobulin biopharmaceuticals, aggregation is a common issue that occurs during all stages of drug development. Since a large number of monoclonal antibody titers are produced in bioreactors, effective aggregate removal techniques are required in manufacturing processes.

From Waters | Wyatt Technology 2 Aug 2014

Characterization of Liposome Size and Encapsulation using FFF-MALS-QELS

Liposomes are synthetic vesicles composed of a lipid bilayer surrounding an aqueous core in which drugs can be contained. These vesicles therefore provide a valuable mechanism for drug delivery in the fields of clinical therapy and research. It is important to monitor liposome size and encapsulation during the research, manufacture, and quality control of these important vesicles.

From Waters | Wyatt Technology 1 Aug 2014

Characterization of Hemoglobin using SEC-MALS Technology

Hemoglobin is a major protein component of mammalian red blood cells that plays a vital role in transporting oxygen from the lungs around the body. Following the release of oxygen, carbon dioxide attaches to the hemoglobin and is then removed from the body.

From Waters | Wyatt Technology 1 Aug 2014

Application of CG-MALS for Analyzing Metacomplex Formation in the Hetero-Association of Multivalent and Bivalent Binding Partners

For standard techniques in the analysis of macro-molecular interactions, such as ELISA and SPR, a binding partner is required to immobilize the molecule on a surface for the measurement of the binding affinity.

From Waters | Wyatt Technology 1 Aug 2014

Characterization of Protein Aggregate Composition using Light Scattering Techniques

Protein aggregation refers to the clumping together or accumulation of mis-folded proteins. This aggregation can occur during the production, administration, storage, and shipping of therapeutic protein compounds, which can compromise their stability, efficacy, and safety.

From Waters | Wyatt Technology 1 Aug 2014

Measuring Intrinsic Protein Fluorescence with Modular Spectroscopy Tools

Protein structure and function can be accurately studied using intrinsic fluorescence measurements. A better understanding about the activity or conformational states of proteins under various temperatures, pH, and ion concentrations can be achieved by estimating the quantity of fluorescence.

From Ocean Insight 1 Aug 2014

Characterization of Monomers, Dimers and Hexamers of Insulin using MALS and Column Chromatography (SEC/GPC)

Generally, in protein and peptide analyses, knowing a molecule’s oligomeric state is useful in determining whether the protein exists in its biologically active form. To this end, the first step usually involves separating and characterizing the molecular species using size exclusion chromatography (SEC).

From Waters | Wyatt Technology 31 Jul 2014

Application of Composition-gradient Multi-angle Light Scattering for Measuring the Self-Association of Insulin

Composition-gradient multi-angle light scattering (CG-MALS) is a biophysical technique that can be used to measure the self-association of macromolecules in solution. This technique allows fast, reproducible, and label-free measurement of this self-association.

From Waters | Wyatt Technology 31 Jul 2014

Using Molecular Weight and Net Charge to Discriminate Contaminated and Unmodified Heparin Lots

Heparin is an injectable anticoagulant that has been used for medical purposes for more than seven decades. However, this agent has come under considerable scrutiny after certain pharmaceutical lots have been found to contain chondroitin sulfate. Therefore, advanced characterization techniques are needed to accurately determine the exact chemical composition of heparin lots.

From Waters | Wyatt Technology 31 Jul 2014

Life Science White Papers

Importance of Spectral Quality in Spectroscopy and Disinfection Applications

Analysis of Pharmaceutical Particles Using Phenom desktop Scanning Electron Microscope

Changes to ISO 14644-1 Standard Improves Confidence in Cleanroom Performance for Critical Life-Science Applications

Using MET ONE HHPC 6+ Particle Counter for Classification of Clean Room

Comparison of Instrument-to-Instrument Variability Using Vi-CELL Automated Cell Viability Analyzer

Automated Measurements of Whole Blood and White Blood Cell Viability Using Beckman Coulter Reagents

Using Automated Cell Counters for Seasonal Comparison of Cells

Applications of KSV NIMA Analytical Instruments in Studying Biomolecular Interactions in Cell Membrane Models

Using QCM-D Technique to Improve Drug Research and Development

Imaging and Biosimulation Platform to Advance Drug Discovery and Development for CNS Diseases

Application of ASTRA 6 Software Tool for Analysis of Drug-Antibody Components

Nanoparticle and Macromolecular Analysis using the DynaPro DLS Plate Reader

Characterization of Liposome Size and Encapsulation using FFF-MALS-QELS

Characterization of Hemoglobin using SEC-MALS Technology

Application of CG-MALS for Analyzing Metacomplex Formation in the Hetero-Association of Multivalent and Bivalent Binding Partners

Characterization of Protein Aggregate Composition using Light Scattering Techniques

Measuring Intrinsic Protein Fluorescence with Modular Spectroscopy Tools

Characterization of Monomers, Dimers and Hexamers of Insulin using MALS and Column Chromatography (SEC/GPC)

Application of Composition-gradient Multi-angle Light Scattering for Measuring the Self-Association of Insulin

Using Molecular Weight and Net Charge to Discriminate Contaminated and Unmodified Heparin Lots

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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