1. Peter Kinnon Peter Kinnon New Zealand says:

    The while aspects of this work are of interesting, the presentation of this article is rather misleading.

    The very common notion that "DNA creates the organism"  is very wrong.  Implications of this kind can all too easily help propagate the myth that structural and behavioral changes are driven by the gene (or group of genes) rather than by selection pressure, a function of the overall evolutionary network.

    It is important to bear in mind that the genome is merely a rather small library of protein recipes. It is entirely passive. It is actively manipulated, maintained and accessed by RNA and other cellular machinery.

    Machinery that is directly inherited, complete with RNA, organelles, the transcriptome, and all other structures required for function. All as a result of cell division.  DNA being merely a rather small reference library that is accessed for instructions for the manufacture of “spare parts”.

    In my writings, rather than the “switches” used in this article, I employ the analogy of a piano to represent DNA. The piano itself is entirely passive, as is DNA. But a pianist can produce innumerable musical variations by using this passive array of strings.

    In biology, the pianist corresponds to the machinery of the cell together with the inputs from its environment. Some of which control differentiation.

    Biological evolution is, after all, a network function.

    The network model of inheritance and morphogenesis is explored more fully in my latest book "The Intricacy Generator: Pushing Chemistry and Geometry Uphill", a 336 page illustrated paperback now available from Amazon, etc

    Also of great relevance to this  topic is Franklin M Howard's excellent "The Way of The Cell.  A "must read".for anybody interested in such matters.

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
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