I have been having bowel issues for many years also. I was put on Linzess not long after it hit the market. It never worked for me. So when my insurance changed this year, the copay for Linzess sky rocketed so I stopped using it. Several months have gone by and hit and miss with the bathroom. Yesterday I started taking Amitiza Cap 24 mcg twice a day. I get very sick and stomach cramping for the first couple hours afterwards. I hope I get some relief from this medication. Linzess is a waste of money. Looking up solutions to constipation not by a disease but by symptoms has helped me locate alternate meds. I hope somthing helps for you.