1. The difference is, ALKS 5461 is being used not as an opioid, but rather the
    Biochem Nerd Biochem Nerd United States says:
    September 19, 2012 at 8:07 PM

    The difference is, ALKS 5461 is being used not as an opioid, but rather the opposite. Buprenorphine is (among other less significant actions) an activator of mu opioid receptors and an antagonist of kappa opioid receptors. ALKS 5461 combines this with samidorphan, a selective blocker of my opioid receptors, which mediate most of the euphoria/tolerance/addiction of opiates. The remaining activity is a blockade of the kappa receptor, activation of which is super important in mediating the dysphoric response to stress. Totally different drug, I'll eagerly watch this one!

    Reply
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