The rapifleX Maldi PharmaPulse MPP® (Bruker) and CyBio® Well Vario pipettor (Analytik Jena) are now fully integrated in the ultra-High Throughput Screening (uHTS) robotic platform at Pivot Park Screening Centre. This revolutionary hit finding technology combined with automated sample-matrix spotter enables screening of large compound libraries in 1536-well plate format.
Direct quantification of reaction product(s) without the need for fluorescent labels, improves the quality of uHTS output by reducing the likelihood of false positive and negative datapoints, facilitating a more time- and cost-effective hit-to-lead phase. During this tutorial, we will discuss the integration of rapifleX MPP® and the CyBio® Well Vario in our uHTS platform. Moreover, we will present details of a successful screening campaign of over 0.5 million compounds using label-free MS technology during the scientific seminar of PPSC.
Run time: 19:53 mins
Fleur Kleinpenning, PhD, ScientistPivot Park Screening CentreOss, Gelderland, Netherlands, SLAS 2021
Video Credit: Bruker Life Sciences Mass Spectrometry