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People who lower stress levels through meditation, yoga have longer telomeres

Targeting telomeres, the protective caps at the end of all chromosomes that are critical to healthy cell function, T.A. Sciences' products activate an enzyme that can slow down and possibly reverse age- and lifestyle-related telomere shortening. Short telomeres can cause mutations and degradations to chromosomes leading to loss of cell functionality. Its inaugural product, TA-65 is the only proven product specifically focused on the telomerase activation market.

12 Oct 2013

Novartis Inks Agreement For Immunogen's "TAP" ADC Technology

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11 Oct 2013

Novartis Inks Agreement For Immunogen's "TAP" ADC Technology

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11 Oct 2013

High voltage, short pulsed electric fields destroy cells in skin tissue, lead to scarless tissue regeneration

High voltage, short pulsed electric fields, used for disinfection and solid tumor destruction, selectively damage cell membranes, while preserving overall tissue structure, a phenomenon that may be a key factor in scarless tissue regeneration.

11 Oct 2013

ImmunoGen signs new license agreement with Novartis

ImmunoGen, Inc., a biotechnology company that develops novel anticancer therapeutics using its antibody-drug conjugate technology, today announced that Novartis has licensed the exclusive right to use the Company's ADC technology to develop anticancer therapeutics to an undisclosed target.

11 Oct 2013

New gene transfer strategy effective for achieving persistent immunotherapy to treat tumors

Cancer immunotherapy can successfully use the body's own immune system to kill tumor cells. But some current approaches to stimulate an antitumor immune response are short-lived, with limited clinical effectiveness. A new gene transfer strategy that introduces modified, immune-stimulating human stem cells is both feasible and effective for achieving persistent immunotherapy to treat leukemias and lymophomas, according to a study published in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

11 Oct 2013

HSCI researchers discover on-off switch for gene expression

Harvard Stem Cell Institute researchers have settled a century-old debate over whether occurrence of DNA methylation acts to silence gene expression, or if genes are turned off by other means before they are methylated.

11 Oct 2013

Super-enhancers could play important roles in disease diagnostics and therapeutics

Having recently discovered a set of powerful gene regulators that control cell identity in a few mouse and human cell types, Whitehead Institute scientists are now showing that these regulators-which they named "super-enhancers"-act across a vast array of human cell types and are enriched in mutated regions of the genome that are closely associated with a broad spectrum of diseases.

11 Oct 2013

Scientists develop new method to create stem cells for human liver and pancreas

A new method for creating stem cells for the human liver and pancreas, which could enable both cell types to be grown in sufficient quantities for clinical use, has been developed by scientists.

11 Oct 2013

TSRI scientists discover viable strategy for weight loss in people

Scientists at The Scripps Research Institute have discovered key details of a brain-to-body signaling circuit that enables roundworms to lose weight independently of food intake. The weight-loss circuit is activated by combined signals from the worm versions of the neurotransmitters serotonin and adrenaline, and there are reasons to suspect that it exists in a similar form in humans and other mammals.

11 Oct 2013

Scientists to combine NK cell therapy with immunocytokine to target childhood cancer

Researchers have made rapid advances in understanding how to manipulate the immune system safely to destroy cancer cells. Adoptive transfer of haploidentical natural killer cells has shown promise as a treatment option to target and kill cancer cells in a less toxic way than conventional therapies. Now for the first time, scientists will combine NK cell therapy with an immunocytokine to target children with relapsed/refractory disease including those with bulky tumors.

11 Oct 2013

Genetic mutation that protects skin from UV radiation may cause testicular cancer in Caucasian

A Ludwig Cancer Research study published in Cell today identifies a common mutation that dramatically increases the risk for testicular cancer—and describes a likely molecular mechanism by which it exerts that effect.

11 Oct 2013

Osiris Therapeutics agrees to sell ceMSC business to Mesoblast

Osiris Therapeutics, Inc. announced today that it has entered into an agreement with a wholly-owned subsidiary of Mesoblast Limited for the sale of Osiris' culture-expanded mesenchymal stem cell business, including Prochymal, in a transaction worth up to $100 million in initial consideration and milestone payments.

11 Oct 2013

FDA accepts, files Genentech's sBLA for subcutaneous use of Xolair in people with CIU

Genentech, a member of the Roche Group, today announced that the U.S. Food and Drug Administration has accepted and filed the company's supplemental Biologics License Application for subcutaneous use of Xolair (omalizumab) in people with Chronic Idiopathic Urticaria who remained symptomatic despite treatment with H1-antihistamine therapy at approved doses.

11 Oct 2013

Specialized cells in the stomach more often revert to stem cells

New research has shown that the stomach naturally produces more stem cells than previously realized, likely for repair of injuries from infections, digestive fluids and the foods we eat.

11 Oct 2013

Researchers find ways to identify, isolate HCC progenitor cells before tumors become evident

For the first time, researchers at the University of California, San Diego School of Medicine have isolated and characterized the progenitor cells that eventually give rise to malignant hepatocellular carcinoma tumors - the most common form of liver cancer. The researchers found ways to identify and isolate the HCC progenitor cells long before actual tumors were apparent.

11 Oct 2013

Researchers identify gene that orchestrates important branching of nerve fibers

Our ability to detect heat, touch, tickling and other sensations depends on our sensory nerves. Now, for the first time, researchers at Albert Einstein College of Medicine of Yeshiva University have identified a gene that orchestrates the crucially important branching of nerve fibers that occurs during development. The findings were published online today in the journal Cell.

11 Oct 2013

Suppression of mitochondria: A dominant feature of diabetic kidney disease

Researchers at the University of California, San Diego School of Medicine have identified 13 metabolites - small molecules produced by cellular metabolism - that are significantly different in patients with diabetes and chronic kidney disease compared to healthy controls.

11 Oct 2013

Small interfering RNAs in mammals act as specific antiviral weapons

Many viral infections are nipped in the bud by the innate immune response. This involves specific proteins within the infected cell that recognize the virus and trigger a signalling cascade - the so-called interferon response. This activates a protective mechanism in neighbouring cells and often results in the death of the primarily infected cell.

11 Oct 2013

Finding highlights new ways of treating inflammation disorders

A team led by scientists at The Scripps Research Institute (TSRI) has identified key signaling proteins in the inflammation process that contribute to the development of inflammatory diseases such as rheumatoid arthritis, psoriasis, sepsis and inflammatory bowel diseases.

11 Oct 2013

Cell News and Research

People who lower stress levels through meditation, yoga have longer telomeres

Novartis Inks Agreement For Immunogen's "TAP" ADC Technology

Novartis Inks Agreement For Immunogen's "TAP" ADC Technology

High voltage, short pulsed electric fields destroy cells in skin tissue, lead to scarless tissue regeneration

ImmunoGen signs new license agreement with Novartis

New gene transfer strategy effective for achieving persistent immunotherapy to treat tumors

HSCI researchers discover on-off switch for gene expression

Super-enhancers could play important roles in disease diagnostics and therapeutics

Scientists develop new method to create stem cells for human liver and pancreas

TSRI scientists discover viable strategy for weight loss in people

Scientists to combine NK cell therapy with immunocytokine to target childhood cancer

Genetic mutation that protects skin from UV radiation may cause testicular cancer in Caucasian

Osiris Therapeutics agrees to sell ceMSC business to Mesoblast

FDA accepts, files Genentech's sBLA for subcutaneous use of Xolair in people with CIU

Specialized cells in the stomach more often revert to stem cells

Researchers find ways to identify, isolate HCC progenitor cells before tumors become evident

Researchers identify gene that orchestrates important branching of nerve fibers

Suppression of mitochondria: A dominant feature of diabetic kidney disease

Small interfering RNAs in mammals act as specific antiviral weapons

Finding highlights new ways of treating inflammation disorders

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