High voltage, short pulsed electric fields, used for disinfection and solid tumor destruction, selectively damage cell membranes, while preserving overall tissue structure, a phenomenon that may be a key factor in scarless tissue regeneration.
The enigma of scars has puzzled human mind for thousands of years. Any organ or tissue after serious injury forms a scar. The mechanism by which scars form are not known, and there are very limited therapies available to block scar formation. Now, a team based at the Center for Engineering in Medicine at the Massachusetts General Hospital report that high voltage short electric fields appear to destroy all cells in skin tissue but lead to full regeneration with no scars. These strong but short pulsed electric fields selectively kill the cells, while preserving the extracellular matrix tissue structure including the local blood supply, which are needed for healthy tissue growth and functional regeneration.
"It is a fascinating finding," says Alexander Golberg, PhD of MGH, the paper's first author. "We compared this technique with thermal burns and found many different aspects post-injury both in terms of the extent of damage and the dynamics of recovery”.
Currently, pulsed electric fields are primarily used for disinfection and solid tumor ablation. Pulsed fields selectively kill cells in the tissue presumably by a mechanism called irreversible electroporation. After exposure to the fields, large pores appear in cell membranes that eventually lead to cell death.