Analgesia News and Research

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FDA approves Pacira's EXPAREL for postsurgical pain management

Pacira Pharmaceuticals, Inc. announces that the U.S. Food and Drug Administration (FDA) has approved EXPAREL 1.3% for administration into the surgical site to produce postsurgical analgesia.

31 Oct 2011

Multimodal analgesia is used less than 25% of the time prior to surgery

Many surgical patients are concerned about the level of pain they will experience. In a new study presented at ANESTHESIOLOGY 2011, researchers from Thomas Jefferson University identified that multimodal analgesia, a combination of pain medication and therapeutic measures to improve pain control, is used less than 25 percent of the time prior to surgery.

19 Oct 2011

Researchers control itch without dulling morphine's pain-killing effects

Itching is one of the most prevalent side effects of powerful, pain-killing drugs like morphine, oxycodone and other opioids. The opiate-associated itch is so common that even women who get epidurals for labor pain often complain of itching. For many years, scientists have scratched their own heads about why drugs that so effectively suppress pain also induce itch.

14 Oct 2011

Hippocampus plays an active role in suppressing pain during times of stress

New findings about how the brain functions to suppress pain have been published in the leading journal Pain, by NUI Galway researchers. For the first time, it has been shown that the hippocampus of the brain, which is usually associated with memory, has an active role to play in suppressing pain during times of stress.

13 Oct 2011

Cannabidiol could prevent onset of pain associated with chemotherapy drugs

A chemical component of the marijuana plant could prevent the onset of pain associated with drugs used in chemo therapy, particularly in breast cancer patients, according to researchers at Temple University's School of Pharmacy.

7 Oct 2011

Anesthesia in very small kids may raise risk of learning disabilities

According to the latest research very young children exposed to general anesthesia during surgical procedures may be at an increased risk for learning problems.

4 Oct 2011

Study confirms that CNAP-PPV method offers precise therapy control during surgery

The well-established high tech company CNSystems once again attracts international attention with a big mile stone. The Bordeaux University Hospital (France) confirms that the validated CNAP blood pressure wave offers the possibility of precise therapy control during surgery.

1 Oct 2011

Pacira announces data from EXPAREL clinical study presented at ASPS 2011 meeting

Pacira Pharmaceuticals, Inc. today announced that the company's lead investigational product for postsurgical pain management, EXPAREL, was highlighted in the "Hot Topics in Plastic Surgery" panel at the annual scientific assembly of the American Society of Plastic Surgeons (ASPS) in Denver, Colo.

26 Sep 2011

New insights into actions of NSAIDs

Ibuprofen, naproxen, and related non-steroidal anti-inflammatory drugs (NSAIDs) - the subjects of years of study - still have some secrets to reveal about how they work.

26 Sep 2011

Cannabidiol may help prevent paclitaxel-induced peripheral neuropathy

Cannabidiol—a compound derived from marijuana—may be a promising new treatment to prevent the development of painful neuropathy in patients receiving the chemotherapy drug paclitaxel, according to animal experiments reported in the October issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society.

26 Sep 2011

No link between duration or depth of general anesthesia and subsequent cancer risk

Helping to allay fears raised by previous studies, a new report finds no link between the duration or depth of general anesthesia and the subsequent risk of developing cancer, according to the October issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society.

26 Sep 2011

The Journal of Pain publishes results from Butrans Transdermal System Phase 3 clinical study

Butrans (Buprenorphine) Transdermal System CIII 20 mcg/hour provided significantly lower "average pain over the last 24 hours" scores compared to Butrans 5 mcg/hour when used in opioid-experienced patients with moderate-to-severe chronic low back pain, according to a pivotal Phase 3 clinical study published in the online, August issue of The Journal of Pain.

26 Sep 2011

Multimodal analgesia important for effective control of pain

Efforts to effectively control pain in hospitalized patients with opioid (narcotic) analgesics can lead to unintentional sedation and respiratory depression, which are serious adverse events affecting the quality of recovery for patients.

20 Sep 2011

Study finds no clear advantage of ultrasound guidance for pain relief in nerve block procedures

Using ultrasound to guide the performance of nerve blocks—in which anesthetics are directly targeted to a specific nerve or group of nerves—has contributed to the increased use of regional anesthesia.

17 Sep 2011

P3 survey: 44% of U.S. patients receive inadequate relief of moderate-to-severe acute pain

A new survey shows almost half (44%) of U.S. patients in outpatient settings received potentially inadequate relief of moderate-to-severe acute pain.

15 Sep 2011

Preterm babies may be experiencing pain during procedures: Study

Preterm may begin to feel pain around a woman's 35th week of pregnancy, about two to four weeks before delivery, according to a new study from University College London. Using EEG, researchers recorded the babies' brain activity in response to pain, comparing their pain responses from a touch and prick on the heels. The findings were published in the journal Current Biology.

9 Sep 2011

Enrollment complete in DURECT's POSIDUR Phase III study for post-surgical pain

DURECT Corporation announced today the dosing of the last patient in the U.S. pivotal Phase III clinical study for POSIDUR known as BESST.

6 Sep 2011

ICS, Quintiles enter agreement with Pacira to support launch of EXPAREL

Pacira Pharmaceuticals, Inc., an emerging specialty pharmaceutical company, today announced that it has entered into agreements with Quintiles Commercial US, Inc. and Integrated Commercialization Services, Inc. (ICS) to support the anticipated launch of EXPAREL, should it be approved by the Food and Drug Administration (FDA) later this year.

6 Sep 2011

New Pressurized Olfactory Device shows direct CNS effect of morphine

A simple new approach to nasal drug administration may allow morphine and other strong pain medications to be targeted directly to the central nervous system (CNS), reports an experimental study in the September issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society.

24 Aug 2011

IARS launches $750,000 anesthesia research grant

The International Anesthesia Research Society (IARS) launched a $750,000 research grant today - the largest single grant offered by the Society in its 90 year history. The Frontiers in Anesthesia Research Award, created in 1995, has traditionally been a $500,000 grant.

24 Aug 2011