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Enzo Biochem to release a new catalog dealing with epigenetics and chromatin modification

Enzo Biochem, Inc. today said that its Life Sciences subsidiary will release a new catalog dealing with “Epigenetics & Chromatin Modification” at the Society for Neuroscience’s, Neuroscience 2009 conference, beginning October 17, 2009, in Chicago, Illinois.

15 Oct 2009

New apoptosis detection kit for monitoring chromatin condensation

Enzo Biochem, Inc.’s Enzo Life Sciences division today announced the addition of a new apoptosis detection kit for monitoring chromatin condensation to its rapidly expanding CELLestial™ product line for live cell analysis.

7 Oct 2009

Brdt protein in developing sperm cells direct tight re-packaging of sperm DNA

In the quest for speed, olympic swimmers shave themselves or squeeze into high-tech super-suits. In the body, sperm are the only cells that swim and, as speed is crucial to fertility, have developed their own ways to become exceptionally streamlined. Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg and Grenoble, the Institut de Biologie Structurale (IBS) and the Institut Albert Bonniot, both also in Grenoble, have been studying the secrets of speedy sperm.

1 Oct 2009

eChIP genetic technique developed to examine FA proteins with DNA crosslinks

While Fanconi anemia (FA) is a rare and dangerous disease, new laboratory research at The University of Texas M. D. Anderson Cancer Center shows it may lead researchers toward clues in more common diseases, including highly hereditary types of breast cancer.

11 Sep 2009

Research reveals that large non-coding RNA in mammals play an important role in telomere maintenance

A team of researchers from The Wistar Institute have shown that a large non-coding RNA in mammals and yeast plays a central role in helping maintain telomeres, the tips of chromosomes that contain important genetic information and help regulate cell division. Since this RNA also facilitates the formation of DNA at telomeres-a process that can protect aging cells and destabilize tumor cells-manipulating its expression may be useful in treating cancer and other diseases.

1 Sep 2009

Bayer Crop Science uses Chromatin's proprietary mini-chromosome technology

Chromatin Inc. and Bayer CropScience announced today that they have entered into a technological alliance and license agreement to use Chromatin’s proprietary mini-chromosome technology for crop improvement.

20 Aug 2009

Protein plays unexpected role protecting chromosome tips

A protein specialist that opens the genomic door for DNA repair and gene expression also turns out to be a multi-tasking workhorse that protects the tips of chromosomes and dabbles in a protein-destruction complex, a team lead by researchers at The University of Texas M. D. Anderson Cancer Center reports in the Aug. 13 edition of Molecular Cell.

13 Aug 2009

Discovery of 'marker' molecule offers hope for liver cancer test

Cancer Research UK scientists have discovered a 'marker' molecule which could pinpoint when liver cells start to become cancerous, reveals research published in Science*.

9 Aug 2009

Discovery of DNA mutation that occurs at beginning point of T-cell lymphoma

Researchers at the Keck School of Medicine of the University of Southern California (USC) have identified a key mechanism that causes chromosomes within blood cells to break - an occurrence that marks the first step in the development of human lymphoma.

13 Jun 2009

“Misreading” of histone code linked to human cancer

The development of blood from stem cell to fully formed blood cell follows a genetically determined program. When it works properly, blood formation stops when it reaches maturity. But when it doesn't, genetic mutations can prevent the stop signal and cause the developing cells to turn cancerous. In research published in Nature, Rockefeller University scientists show for the first time that a misreading of the blood cells' histone code is responsible for acute myeloid leukemia, a rare form of the deadly blood cancer.

1 Jun 2009

Research shows how cocaine regulates gene expression in a crucial reward region

The study, published by Cell Press in the May 14th issue of the journal Neuron, provides exciting insight into the molecular pathways regulated by cocaine and may lead to new strategies for battling drug addiction.

13 May 2009

Scientists develop tool to study a deadly parasite’s histone code

In the Japanese art of paper folding, a series of folds can make the same sheet of paper into a ballerina or baby elephant. But try unfolding the baby elephant and making it into a ballerina. It's like trying to make a neuron from a kidney cell. Epigenetics, it turns out, isn't much different from this old Japanese art: Each fold, or epigenetic crease, both limits and permits further potential folds in a way that mirrors how epigenetic changes seal a cell's fate.

13 May 2009

Discovery of gene key to Alzheimer's-like reversal

A team led by researchers at MIT's Picower Institute for Learning and Memory has now pinpointed the exact gene responsible for a 2007 breakthrough in which mice with symptoms of Alzheimer's disease regained long-term memories and the ability to learn

6 May 2009

SUMO protein guides chromatin remodeler to suppress genes

In an in vitro study, led by Grace Gill, PhD, Tufts University School of Medicine, researchers discovered how a protein called SUMO (Small Ubiquitin-related Modifier) guides an enzyme complex that alters the structure of chromatin to regulate expression of genes.

27 Apr 2009

Discovery of key genetic factors that drive the process of generating new heart cells

Scientists at the Gladstone Institute of Cardiovascular Disease have identified for the first time key genetic factors that drive the process of generating new heart cells.

26 Apr 2009

The DNA proteome

The human genome complete sequencing project in 2003 revealed the enormous instruction manual necessary to define a human being.

22 Apr 2009

When every photon counts: unusual cell nuclei help nocturnal animals see better

The eyes of nocturnal mammals have very large numbers of highly-sensitive rod photoreceptors (the cell type responsible for night vision).

16 Apr 2009

Secret to night vision in nocturnal animals revealed

Researchers have discovered an important element for making night vision possible in nocturnal mammals: the DNA within the photoreceptor rod cells responsible for low light vision is packaged in a very unconventional way, according to a report in the April 17th issue of Cell , a Cell Press publication.

16 Apr 2009

Researchers explain process by which cells 'hide' potentially dangerous DNA segments

The DNA in the 23 pairs of chromosomes in each of the billions of cells of the human body is so tightly packed that it would measure six feet in length if stretched end to end.

12 Apr 2009

Researchers discover structure-building role for 2 non-coding RNAs

Most of the DNA in the nucleus of each of our cells is converted into RNA, but only a small fraction of these RNA molecules serve as coding templates for the synthesis of proteins.

2 Apr 2009