A team of researchers from The Wistar Institute have shown that a large non-coding RNA in mammals and yeast plays a central role in helping maintain telomeres, the tips of chromosomes that contain important genetic information and help regulate cell division. Since this RNA also facilitates the formation of DNA at telomeres-a process that can protect aging cells and destabilize tumor cells-manipulating its expression may be useful in treating cancer and other diseases.
The steady shortening of telomeres with each replication in somatic cells is linked to cellular aging, genetic instability, and tumor formation. This is because telomeres eventually "run out" after a certain number of cell divisions, resulting in the loss of vital genetic information from the cell's chromosome with future divisions. Scientists recently identified telomere-repeat-encoding RNA (TERRA) as an integral component of DNA within the telomeres of multiple species. The Wistar team demonstrated how TERRA mediates and partially stabilizes interactions between telomeric proteins that play essential roles in DNA replication.
"TERRA is a major component in helping protect the genome at a very sensitive place, the telomeres," said senior author Paul M. Lieberman, Ph.D., a professor in Wistar's Gene Expression and Regulation Program. "By managing TERRA levels we have the potential to regulate cellular aging and to impair the functioning of cancer cells."