Cardiomyopathy News and Research

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Cardiomyopathy is a group of diseases with primary, usually diffuse, involvement of the myocardium. The myocardial disease is not secondary to ischaemic, valvular, congenital or pericardial disease.

Significant step forward in the genome era

In what promises to be a significant step forward in the genome era, the National Human Genome Research Institute (NHGRI) today announced plans to devote a portion of its large-scale sequencing capacity to efforts aimed at identifying the genetic roots of specific diseases that have long eluded gene hunters.

17 Oct 2005

New insights that advance the current model of protein motility and muscle contraction

Scientists from the Burnham Institute for Medical Research and the University of Vermont have captured the first 3-dimensional (3D) atomic-resolution images of the motor protein myosin V as it "walks" along other proteins, revealing new structural insights that advance the current model of protein motility and muscle contraction.

3 Oct 2005

C. elegans worm provides clues to dealing with human disease

A step towards understanding cell mutations that cause a variety of human diseases, particularly in children -- including that which brings about premature aging and early death -- has been taken by researchers at the Hebrew University of Jerusalem Silberman Institute of Life Sciences and the John Hopkins University School of Medicine.

1 Sep 2005

Step towards understanding cell mutations that cause a variety of human diseases

A step towards understanding cell mutations that cause a variety of human diseases, particularly in children - including that which brings about premature aging and early death - has been taken by researchers at the Hebrew University of Jerusalem Silberman Institute of Life Sciences and the John Hopkins University School of Medicine.

30 Aug 2005

Early statin therapy may be essential for reducing mortality and other complications in heart attack victims

In the largest clinical study of its kind, UCLA researchers found that early treatment with a statin drug within 24 hours of having a heart attack reduced in-hospital mortality rates by over 50 percent.

29 Aug 2005

Using muscle tissue from tarantulas scientists discover how muscles relax

Using muscle tissue from tarantulas, an HHMI international research scholar and his colleagues have figured out the detailed structure and arrangement of the miniature molecular motors that control movement.

24 Aug 2005

Contrast-enhanced MRI is better than SPECT in detecting heart damage in patients with hypertrophic cardiomyopathy

SPECT nuclear medicine studies are currently the most common way to look for myocardial damage in these patients; however; a new study, published in the August issue of the American Journal of Roentgenology, found that MRI is a more comprehensive examination than SPECT.

10 Aug 2005

Surgical myectomy gives fresh start to patients with hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM), an abnormal thickening of the heart, affects more than 500,000 Americans, making it more common than better-known conditions such as Crohn's disease, Multiple Sclerosis and Anorexia Nervosa.

2 Aug 2005

Chemical sealant - poloxamer 188 can repair damage to cardiac muscle cell membrane

A common chemical used in the manufacturing and pharmaceutical industries can repair damage to cardiac muscle cell membranes and prevent heart failure in mice with the genetic mutation that causes Duchenne muscular dystrophy, according to scientists at the University of Michigan Medical School.

18 Jul 2005

Study compares four standard measures for heart failure treatment

UCLA investigators found large gaps and marked variation in U.S. hospitals' heart failure treatment based on adherence to four standard quality measures. The study points to the need for hospitals to establish education programs and systems to improve quality of care for this patient population.

11 Jul 2005

Simple blood test can quickly identify type of congestive heart failure

A simple blood test can quickly identify what type of congestive heart failure (CHF) a patient has, improving diagnostic accuracy; eliminating the need for extensive diagnostic tests, such as heart muscle biopsy or exploratory surgery; and enabling the patient to be treated sooner, according to a study published in the June 7 Journal of the American College of Cardiology.

6 Jun 2005

Women more vulnerable to chronic drinking than men are

A study in the May issue of Alcoholism: Clinical & Experimental Research addresses this gap in research, using computed tomography (CT) to examine brain atrophy in the brains of alcoholic men and women. The findings support and build upon a prior hypothesis that women develop alcohol-related brain damage more readily than men.

16 May 2005

Australian-designed heart pump gives new hope to heart patients

A 56-year-old New Zealand man, a heart failure patient, is recovering in hospital after world-first surgery to implant an Australian-designed device which helps the heart pump blood.

9 May 2005

Study calls for earlier use of ICDs in patients diagnosed with cardiomyopathy

A study presented today at the Late Breaking Clinical Trials presentations at the Heart Rhythm Society's Annual Scientific Sessions in New Orleans found that implantable cardiac defibrillators (ICD) benefit patients with recently diagnosed cardiomyopathy, a disease that affects the heart muscle's ability to pump and can lead to heart failure.

8 May 2005

Mutated gene causes serious heart disease in newborns

The research group of professor Manfred Kilimann at the Department of Cell and Molecular Biology has elucidated the genetic cause of a severe heart disease in newborn children. This result will be published in the June issue of the American Journal of Human Genetics this week.

3 May 2005

New method for the study of ion channel gating kinetics

An ion channel is a protein pore that lets ions (charged atoms such as calcium) pass through a cell's membrane. The method fits data to a new class of models, called manifest interconductance rank (MIR) models, which will give researchers a better understanding of the mechanisms by which ion channels open and close.

19 Apr 2005

New heart valve ring helps congestive heart failure patients regain lost heart function

A new heart valve ring appears to help congestive heart failure patients regain lost heart function, reversing the disease's effects on heart structure in two ways and easing their disabling symptoms, researchers reported here today at the 85th Annual Meeting of the American Association for Thoracic Surgery.

13 Apr 2005

Why different tissues in the human body vary in their susceptibility to "amyloid" diseases

Researchers at The Scripps Research Institute are reporting the results of a recent study that addresses why different tissues in the human body vary in their susceptibility to "amyloid" diseases, which include Alzheimer's disease and a cluster of ailments called the familial amyloidoses.

7 Apr 2005

Sildenafil prevents anti-cancer drug induced heart damage

Virginia Commonwealth University researchers have found that the popular impotence drug Viagra prevents damage to the heart from a potent chemotherapeutic agent frequently used in the treatment of breast cancer, leukemia and sarcomas.

5 Apr 2005

Alcoholism reduces male heart muscle’s ability to synthesize protein

The fact that men and women react differently to alcohol consumption and addiction, health and behavior risks, disease and death is well known and accepted. Women get drunker faster on less alcohol than men, but fewer women drink either occasionally or heavily, and men are more likely to become dependent on alcohol.

3 Apr 2005