Hippocampus News and Research

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The hippocampus is a part of the forebrain, located in the medial temporal lobe. It belongs to the limbic system and plays major roles in short term memory and spatial navigation. Humans and other mammals have two hippocampi, one in each side of the brain.

Research suggests possibility of using cell transplants to treat schizophrenia

Research from the School of Medicine at The University of Texas Health Science Center at San Antonio suggests the exciting possibility of using cell transplants to treat schizophrenia.

10 Sep 2013

Degeneration of fornix in brain may provide clues to future cognitive decline in healthy old people

The degeneration of a small, wishbone-shaped structure deep inside the brain may provide the earliest clues to future cognitive decline, long before healthy older people exhibit clinical symptoms of memory loss or dementia, a study by researchers with the UC Davis Alzheimer's Disease Center has found.

10 Sep 2013

Locus coeruleus plays major role in learning, memory and other cognitive functions

Death of neurons in the dorsal raphe nucleus and locus coeruleus is a pathological characteristic of the disease. Previous studies concerning the pathological characteristic of Alzheimer's disease mainly focus on learning and memory-related hippocampus, and less attention has been paid to the locus coeruleus.

6 Sep 2013

Resveratrol improves cognition and reduces oxidative stress in rats with vascular dementia

Resveratrol, a polyphenolic compound, is synthesized in several plants and possesses beneficial biological effects, which include anti-oxidant, anti-inflammatory and anti-carcinogenic properties.

5 Sep 2013

Study: Deficiency of protein causes age-related memory loss and Alzheimer's disease

A team of Columbia University Medical Center (CUMC) researchers, led by Nobel laureate Eric R. Kandel, MD, has found that deficiency of a protein called RbAp48 in the hippocampus is a significant contributor to age-related memory loss and that this form of memory loss is reversible.

29 Aug 2013

Alzheimer’s drug trial: an interview with Geoffrey Kempler, Chairman & CEO Prana Biotechnology

Approval for the IMAGINE trial was granted by the Austin Health Research Ethics Committee in November 2011, with the first patients dosed in March the following year. However, well before the trial was approved, PBT2 had already shown promise in significantly changing Abeta levels in spinal fluid while improving cognition in a previous 12-week trial conducted in 2006.

28 Aug 2013

Research shows specific form of memory associations is encoded in cerebral cortex

'Where' and 'how' memories are encoded in a nervous system is one of the most challenging questions in biological research. The formation and recall of associative memories is essential for an independent life. The hippocampus has long been considered a centre in the brain for the long-term storage of spatial associations.

28 Aug 2013

Stem cell therapy improves radiation-induced cognitive impairment

Patients receiving cranial irradiation treatment for brain cancer may find the treatment life-saving, but often suffer progressive and debilitating cognitive detriments, including spatial learning and memory deficits. The cognitive deficits are a contributing factor to the often significant adverse impacts on the surviving patients' quality of life after radiation therapy. In an effort to improve post-irradiation cognitive impairment, scientists at the University of California, Irvine, and colleagues at Neuralstem, Inc. (Rockville, MD), have transplanted fetal stem cells into laboratory animals with radiation-induced cognitive impairments and found that this led to a number of cognitive improvements.

23 Aug 2013

Brain Study Suggests New Way To Treat Anxiety

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22 Aug 2013

Psychogenics Picks Up Alzheimer’s Animal Model From USF

PsychoGenics obtained an exclusive license from the University of South Florida to its APP/PS1 double transgenic mice, which co-express the M146L presenilin 1 (PS1) mutation and the double mutations at K670N/M671L (Swedish mutation) in the amyloid precursor protein (APP).

22 Aug 2013

In dynamic mind-body interaction, brain recruits cells from immune system to promote anxiety

New research shows that in a dynamic mind-body interaction during the interpretation of prolonged stress, cells from the immune system are recruited to the brain and promote symptoms of anxiety.

22 Aug 2013

Research reveals that brain circuits can help reduce anxiety disorders

Anxiety disorders, which include posttraumatic stress disorder, social phobias and obsessive-compulsive disorder, affect 40 million American adults in a given year. Currently available treatments, such as antianxiety drugs, are not always effective and have unwanted side effects.

22 Aug 2013

UCLA study suggests third possible cause for AD: Iron accumulation

Alzheimer's disease has proven to be a difficult enemy to defeat. After all, aging is the No. 1 risk factor for the disorder, and there's no stopping that.

21 Aug 2013

Researchers create mouse models to advance the study of unusual deadly diseases

By directly manipulating a portion of the prion protein-coding gene, Whitehead Institute researchers have created mouse models of two neurodegenerative diseases that are fatal in humans. The highly accurate reproduction of disease pathology seen with these models should advance the study of these unusual but deadly diseases.

20 Aug 2013

Study: H3 receptor antagonist can improve brain edema in adult hypoxic rats

Thioperamide, a selective histamine H3 receptor antagonist, can increase histamine content in the brain and improve brain edema in adult hypoxic rats. Brain edema is precisely considered as the important pathological change of neonatal hypoxic-ischemic encephalopathy.

13 Aug 2013

L-3-n-butylphthalide is potentially beneficial drug for treatment of vascular dementia

3-N-butylphthalide, a green botanical medicine, is a successfully synthesized and stable chemical drug used for the treatment of ischemic stroke that has independent intellectual property rights in China.

12 Aug 2013

Neuroscientists discover protein associated with Alzheimer's Disease

A team of neuroscientists has identified a modification to a protein in laboratory mice linked to conditions associated with Alzheimer's Disease. Their findings, which appear in the journal Nature Neuroscience, also point to a potential therapeutic intervention for alleviating memory-related disorders.

12 Aug 2013

Sericin can decrease blood glucose levels and alleviate diabetic hippocampal damage

Preliminary studies by Dr. Zhihong Chen and colleagues from Chengde Medical College have shown that sericin might improve aberrant Akt signaling, decrease heme oxygenase-1 expression in the hippocampus and cerebral cortex, and reduce the apoptosis of hippocampal neurons in diabetic rats, thus protecting the nervous system.

9 Aug 2013

Pregnant rats fed with high-fat diet experience preeclampsia-like syndromes

Preeclampsia is a relatively common pregnancy disorder, characterized by primary hypertension and proteinuria. In patients with severe preeclampsia, eclampsia can develop, causing nervous system symptoms and signs.

9 Aug 2013

Mother's perceived social status predicts child's brain development, stress indicators

A mother's perceived social status predicts her child's brain development and stress indicators, finds a study at Boston Children's Hospital. While previous studies going back to the 1950s have linked objective socioeconomic factors—such as parental income or education—to child health, achievement and brain function, the new study is the first to link brain function to maternal self-perception.

9 Aug 2013

Hippocampus News and Research

Further Reading

Research suggests possibility of using cell transplants to treat schizophrenia

Degeneration of fornix in brain may provide clues to future cognitive decline in healthy old people

Locus coeruleus plays major role in learning, memory and other cognitive functions

Resveratrol improves cognition and reduces oxidative stress in rats with vascular dementia

Study: Deficiency of protein causes age-related memory loss and Alzheimer's disease

Alzheimer’s drug trial: an interview with Geoffrey Kempler, Chairman & CEO Prana Biotechnology

Research shows specific form of memory associations is encoded in cerebral cortex

Stem cell therapy improves radiation-induced cognitive impairment

Brain Study Suggests New Way To Treat Anxiety

Psychogenics Picks Up Alzheimer’s Animal Model From USF

In dynamic mind-body interaction, brain recruits cells from immune system to promote anxiety

Research reveals that brain circuits can help reduce anxiety disorders

UCLA study suggests third possible cause for AD: Iron accumulation

Researchers create mouse models to advance the study of unusual deadly diseases

Study: H3 receptor antagonist can improve brain edema in adult hypoxic rats

L-3-n-butylphthalide is potentially beneficial drug for treatment of vascular dementia

Neuroscientists discover protein associated with Alzheimer's Disease

Sericin can decrease blood glucose levels and alleviate diabetic hippocampal damage

Pregnant rats fed with high-fat diet experience preeclampsia-like syndromes

Mother's perceived social status predicts child's brain development, stress indicators

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