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Study generates comprehensive catalog of diseases linked to variations in HLA genes

A study led by researchers at Vanderbilt University Medical Center and the University of Arizona College of Pharmacy has generated the first comprehensive catalog of diseases associated with variations in human leukocyte antigen genes that regulate the body's immune system.

11 May 2017

New trial aims to prolong remission for pediatric leukemia patients treated with T-cell immunotherapy

After phase 1 results of Seattle Children's Pediatric Leukemia Adoptive Therapy trial have shown T-cell immunotherapy to be effective in getting 93 percent of patients with relapsed or refractory acute lymphoblastic leukemia into complete initial remission, researchers have now opened a first-in-human clinical trial aimed at reducing the rate of relapse after the therapy, which is about 50 percent.

9 May 2017

Novel strategy may improve survival of grafts, outcomes in high-risk corneal transplant patients

Treating donor corneas with a cocktail of molecules prior to transplanting to a host may improve survival of grafts and, thus, outcomes in high-risk corneal transplant patients, according to a new study led by researchers at Massachusetts Eye and Ear.

2 May 2017

Alere introduces first-ever highly sensitive malaria test for asymptomatic infections

Alere Inc., a global leader in rapid diagnostics, today announced the launch of its Alere™ Malaria Ag P.f, a major technological breakthrough in high-sensitivity rapid testing versus currently available malaria RDTs.

27 Apr 2017

Study identifies expression of tumor antigen as marker for aggressive ovarian cancer

Patients who expressed the tumor antigen NY-ESO-1 had more aggressive cancers and were more likely to die early from their disease, according to a large study conducted by Roswell Park Cancer Institute researchers and published online ahead of print in the journal Gynecologic Oncology.

26 Apr 2017

Synthetic scaffold loaded with cancer-fighting T cells effectively shrinks solid tumors

Cellular therapy hasn't had much success in fighting solid tumors, partly because it's been difficult to deliver anti-cancer T cells to the tumors.

25 Apr 2017

UTSW researchers develop new nanoparticle vaccine immunotherapy that targets multiple tumor types

Researchers from UT Southwestern Medical Center have developed a first-of-its-kind nanoparticle vaccine immunotherapy that targets several different cancer types.

24 Apr 2017

Study highlights need for personalized approaches to prostate cancer screening in high-risk black men

A new study indicates that higher prostate cancer death rates among black men in the US may be due to a higher risk of developing preclinical prostate cancer as well as a higher risk of that cancer progressing more quickly to advanced stages.

24 Apr 2017

NIH announces 2017 ICEMR awards for 7 international malaria research centers

The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, today announced approximately $9 million in first-year funding, subject to availability, for seven malaria research centers around the world.

21 Apr 2017

MGH researchers provide direct link between ‘leaky gut’ and chronic inflammatory disease

With the help of genetically engineered mice, scientists at the Massachusetts General Hospital are moving closer to establishing the role that increased intestinal permeability, sometimes called a "leaky gut," plays in chronic inflammatory conditions.

20 Apr 2017

Nanoparticle-programmed immune cells can slow progression of leukemia in mouse model

Researchers at Fred Hutchinson Cancer Research Center have developed biodegradable nanoparticles that can be used to genetically program immune cells to recognize and destroy cancer cells -- while the immune cells are still inside the body.

17 Apr 2017

Vaccine-chemotherapy combination may improve survival for glioblastoma patients

A vaccine targeting cytomegalovirus (CMV) antigen pp65, combined with high-dose chemotherapy (temozolomide), improved both progression-free survival and overall survival for a small group of glioblastoma (GBM) patients.

17 Apr 2017

U.S. Preventive Services Task Force supports Prostate Cancer Screening in men aged 55–69

The Men's Health Network (MHN) is positive on the most recent recommendations of the U.S. Preventive Services Task Force (USPSTF). The task force states that the choice of whether to be screened or not for prostate cancer depends on the men.

12 Apr 2017

Scientists discover protein that helps provide better vaccination response

Researchers have discovered a protein they believe would help make vaccinations more effective and provide protection from other diseases such as cancer.

7 Apr 2017

Protein testing may become potential tool to detect prostate cancer

In 2016, more than 181,000 new cases of prostate cancer were reported in the U.S., according to the American Cancer Society. The prostate-specific antigen (PSA) test is one of the earliest ways clinicians can detect prostate cancers in their patients.

5 Apr 2017

Scientists find new way to detect prostate cancer by 'sniffing' urine

On the list of dreaded medical tests, a prostate biopsy probably ranks fairly high. The common procedure requires sticking a needle into the prostate gland to remove tissue for assessment.

4 Apr 2017

Survey finds alarming rates of shared decision making for prostate cancer screening

A new study finds that while a blood test that helps to screen for prostate cancer remains common, only 30 percent of men in a large national survey reported having a balanced discussion of the advantages and disadvantages of the screening with their doctor.

28 Mar 2017

New genetic test may give men better view on how to deal with prostate cancer risk

Scientists are reporting a test which can predict which patients are most at risk from aggressive prostate cancer, and whether they suffer an increased chance of treatment failure.

27 Mar 2017

UVA researchers discover unexpected interaction between men's testes and immune system

The University of Virginia School of Medicine has again shown that a part of the body thought to be disconnected from the immune system actually interacts with it, and that discovery helps explain cases of male infertility, certain autoimmune diseases and even the failure of cancer vaccines.

25 Mar 2017

Combination of high-intensity ultrasound and immunotherapy may be effective in treating cancer

In a new study published today in JCI Insight, UC Davis researchers have shown that combining high-intensity focused ultrasound with two immunotherapies (a PD-1 checkpoint inhibitor and TLR9 agonist) can produce excellent response rates in mouse models of epithelial cancer.