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Every year, about one million new cases of colon cancer are diagnosed worldwide. About 150,000 new cases are detected each year in the United States. Over a lifetime, about 1 in 19 people develop colon cancer and nearly 50,000 people are expected to die from it in the U.S. this year. According to the American Cancer Society, colon cancer is the third leading cause of cancer-related death in the U.S., accounting for about 10 percent of all cancer deaths.
Duke scientists reveal how gut inflammation increases colon cancer risk

Duke scientists reveal how gut inflammation increases colon cancer risk

Chronic inflammation in the gut increases the risk of colon cancer by as much as 500 percent, and now Duke University researchers think they know why. [More]
Height affects risk of major non-communicable diseases

Height affects risk of major non-communicable diseases

Height is largely genetically determined, but in recent decades the height of children and adults has steadily increased throughout the world: In adulthood the children are almost always significantly taller than their parents. [More]
Researchers identify new targets that may help prevent and cure colon cancer

Researchers identify new targets that may help prevent and cure colon cancer

When the audio on your television set or smart phone is too loud, you simply turn down the volume. What if we could do the same for the signaling in our bodies that essentially causes normal cells to turn cancerous? New discoveries by researchers at the Stephenson Cancer Center at the University of Oklahoma may point to new ways to do just that. [More]
Frequent consumption of nuts may reduce risk of breast, colon, pancreatic and lung cancer

Frequent consumption of nuts may reduce risk of breast, colon, pancreatic and lung cancer

Adding nuts to your diet is associated to a reduction in the risk of cancer. This is the main conclusion of multiple studies that have shown that eating 2 or 3 servings per week (57-84 g) of nuts is associated to a reduction in the risk of some types of cancer (breast, colon, pancreatic and lung cancer). [More]
Certain ethnicities diagnosed with colorectal cancer at younger ages

Certain ethnicities diagnosed with colorectal cancer at younger ages

Even though the possibilities of colorectal cancer increases with age, a new study found that certain ethnicities are starting to be diagnosed with the condition at younger ages than ever before. [More]
The mechanism behind protective cells protecting themselves

The mechanism behind protective cells protecting themselves

Researchers at St. Jude Children's Research Hospital have discovered the mechanism by which immune cells called regulatory T cells keep themselves intact and functional during their demanding task of holding the immune system in check. Such T cells are key to preventing the immune system from attacking the body in autoimmune disease. [More]
Colorectal cancer in younger patients associated with more advanced disease but better survival

Colorectal cancer in younger patients associated with more advanced disease but better survival

Nearly 15 percent of patients diagnosed with colorectal cancer were younger than 50, the age at which screening recommendations begin. [More]
Adjuvant Chemotherapy Colon Cancer Trials Should ‘Stratify By MSI, KRAS, BRAF’

Adjuvant Chemotherapy Colon Cancer Trials Should ‘Stratify By MSI, KRAS, BRAF’

A post hoc analysis of the PETACC-8 trial has revealed an interaction between microsatellite instability and BRAF and KRAS mutation status when determining the prognosis of patients with resected stage III colon adenocarcinoma. [More]
Colon cancer patients lacking CDX2 protein more likely to benefit from chemotherapy

Colon cancer patients lacking CDX2 protein more likely to benefit from chemotherapy

Using a new computer science approach, researchers at University of California, San Diego School of Medicine, Columbia University and Stanford University discovered a distinctive molecular feature — a biomarker — that identified colon cancer patients who were most likely to remain disease-free up to five years after surgery. [More]
Researchers reveal biological connection between obesity and colorectal cancer risk

Researchers reveal biological connection between obesity and colorectal cancer risk

Obesity has long been associated with increased risk of colorectal cancer, but the link has never been understood. Now, a research team led by investigators at Thomas Jefferson University has revealed the biological connection, and in the process, has identified an approved drug that might prevent development of the cancer. [More]
First trials of smart gas sensing pills offer new clues for development of gut disorder treatments

First trials of smart gas sensing pills offer new clues for development of gut disorder treatments

Researchers have conducted the first ever trials of smart pills that can measure intestinal gases inside the body, with surprising results revealing some unexpected ways that fibre affects the gut. [More]
Researchers reveal totally new biological mechanism that underlies cancer

Researchers reveal totally new biological mechanism that underlies cancer

In a landmark study, researchers from the Broad Institute and Massachusetts General Hospital reveal a completely new biological mechanism that underlies cancer. By studying brain tumors that carry mutations in the isocitrate dehydrogenase (IDH) genes, the team uncovered some unusual changes in the instructions for how the genome folds up on itself. [More]
Endoscopic submucosal dissection appears to be effective treatment for patients with throat cancer

Endoscopic submucosal dissection appears to be effective treatment for patients with throat cancer

According to a study in the December issue of GIE: Gastrointestinal Endoscopy, the monthly peer-reviewed scientific journal of the American Society for Gastrointestinal Endoscopy, endoscopic submucosal dissection (ESD) appears to be a safe and effective minimally invasive treatment for patients with superficial pharyngeal (throat) cancer. [More]
UB study traces how enigmatic molecules help cancer self-destruct

UB study traces how enigmatic molecules help cancer self-destruct

You've probably never heard of "sphingolipids" before. But these curiously named organic compounds play a vital role in one of humanity's most well-known diseases: cancer. [More]
Family members of CUP patients at higher risk of developing CUP themselves

Family members of CUP patients at higher risk of developing CUP themselves

Cancer usually begins in one location and then spreads, but in 3 percent to 5 percent of cancer patients, the tissue where a cancer begins is unknown. In these individuals a cancer diagnosis is made because it has metastasized to other sites. Patients with these so-called "cancers of unknown primary," or CUP, have a very poor prognosis, with a median survival of three months. [More]
Reducing cost for screening does not increase colorectal cancer screening rates

Reducing cost for screening does not increase colorectal cancer screening rates

Making colonoscopy available at no cost to eligible Medicare beneficiaries under the Affordable Care Act did not increase the number of people in this target population who regularly undergo the procedure, says a new large scale national study from University Hospitals Case Medical Center Seidman Cancer Center. [More]
Discovery could pave way for targeted therapies to treat penile cancer

Discovery could pave way for targeted therapies to treat penile cancer

Researchers have identified potential genetic alterations in penile cancer that could pave the way for targeted treatments. [More]
Racial disparities exist for black and Hispanic patients undergoing major surgeries in U.S. hospitals

Racial disparities exist for black and Hispanic patients undergoing major surgeries in U.S. hospitals

Considerable racial disparities exist in surgical outcomes for black and Hispanic patients undergoing major cancer and non-cancer surgeries in U.S. hospitals, even among institutions that have already enrolled in a national surgical quality improvement initiative. [More]
RTFCCR grant supports ASCOLT study that evaluates effectiveness of Aspirin in colorectal cancer patients

RTFCCR grant supports ASCOLT study that evaluates effectiveness of Aspirin in colorectal cancer patients

Rising Tide Foundation for Clinical Cancer Research, an international private foundation based in Switzerland, has awarded a US $800,000 grant to be released over two years for the ASCOLT study conducted by Dr John Chia, Senior Consultant Medical Oncologist at the Division of Medical Oncology, National Cancer Centre Singapore. [More]
Scientists reveal why loss of CD73 enzyme in human cancer promotes tumor progression

Scientists reveal why loss of CD73 enzyme in human cancer promotes tumor progression

Scientists have shown for the first time why loss of the enzyme CD73 in human cancer promotes tumor progression. [More]
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