Fibroblast News and Research

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Fibroblasts are connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.

Study explores periodontal status of patients with Chédiak-Higashi syndrome

The International and American Associations for Dental Research have published an article titled "Periodontitis in Chédiak-Higashi Syndrome: An Altered Immunoinflammatory Response" in the JDR Clinical & Translational Research.

31 Aug 2017

Researchers identify cytotoxic nature of two-dimensional black phosphorous

When environmental and soil chemist Baoshan Xing at the University of Massachusetts Amherst began reading in 2014 that a new, two-dimensional material known as layered black phosphorous (BP) was gaining the attention of biomedical researchers for use in drug delivery systems and tumor photothermal therapy, he was both intrigued and concerned.

31 Aug 2017

Study identifies promising drug candidate for treating demyelinating diseases

Brain functions are maintained by the neural network. Neural network is formed by the connection between the neurite, and this connection is supported by the wrapping of myelin.

26 Aug 2017

Study reveals how abdominal fat could increase cancer risk

It's been well established that obesity is a contributor to cancer risk, but how it actually causes cancer is still a question that hasn't been fully explained.

24 Aug 2017

Researchers hint at experimental molecular treatment for heart failure

Researchers report encouraging preclinical results as they pursue elusive therapeutic strategies to repair scarred and poorly functioning heart tissues after cardiac injury – describing an experimental molecular treatment for heart failure.

14 Aug 2017

Researchers develop and validate new assay that detects gene fusions in solid tumors

An assay that identifies a peculiar but important abnormality in cancer cells has been developed and validated by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

14 Aug 2017

Researcher models heart attack in petri dishes to gain insights into cardiac diseases

In petri dishes in her campus laboratory at New Jersey Institute of Technology, Alice Lee is developing colonies of cardiac cells, formed into chambers, that pump and contract like a human heart.

18 Jul 2017

Mildly stressing muscle metabolism reverses diabetes and obesity in mice

Mildly stressing muscle metabolism boosts levels of a beneficial hormone that prevents obesity and diabetes in mice, according to a new study by researchers at the University of Iowa.

28 Jun 2017

Chicken models may shed light on how humans develop sensitive daytime vision

Humans belong to a select club of species that enjoy crisp color vision in daylight, thanks to a small spot in the center of the retina at the back of the eye.

23 Jun 2017

Melbourne study offers hope for better lung cancer treatment

A Melbourne study is set to improve treatment options for patients with the second most common type of lung cancer, lung squamous cell carcinoma, a disease for which new anti-cancer drugs are urgently needed.

13 Jun 2017

Studies offer hope for developing new biomarker and drug for neurodegenerative diseases

Two new studies of progressive, neurodegenerative diseases linked to defects in cells' mitochondria offer hope for developing a new biomarker for research and diagnostics, and a drug for treating such diseases, report researchers at the University of California, Davis.

6 Jun 2017

Scientists identify new gene that prompts muscle stem cells to fuse together

A detour on the road to regenerative medicine for people with muscular disorders is figuring out how to coax muscle stem cells to fuse together and form functioning skeletal muscle tissues.

1 Jun 2017

New therapeutic approach could save diabetics from amputation by promoting wound healing

Diabetic patients frequently have lesions on their feet that are very difficult to heal due to poor blood circulation. In cases of serious non-healing infections, a decision to amputate could be made. A new therapeutic approach, presented recently in the Journal of Investigative Dermatology by Canadian researchers affiliated with the University of Montreal Hospital Research Centre, could prevent these complications by promoting wound healing.

29 May 2017

Biochemical self-destruct trigger guards brain cells when fighting against West Nile virus

In a turnabout, a biochemical self-destruct trigger found in many other types of cells appears to guard the lives of brain cells during an infection with West Nile virus.

18 May 2017

Chemical stimuli by small molecule can improve production of cartilage cells

Cell-based therapies could offer a way to treat cartilage injuries before the ultimate damage of osteoarthritis on articular cartilage.

11 May 2017

Study reveals potential therapeutic target for kidney fibrosis

When the kidneys - vital organs for filtering the body's entire blood supply - become injured, it can set in motion an unfortunate chain of events that leads to a decline in health.

20 Apr 2017

Review provides new understanding of cytokine mediated effects on inflammatory disorders

Researchers studying chronic inflammation that can lead to the development of lung diseases such as asthma, pulmonary fibrosis, and cancer, are focusing on the role cytokines play in regulating the behavior of fibroblast cells and the extracellular matrix.

24 Mar 2017

Researchers use animal model to study brain abnormality in human TD patients

Thanatophoric dysplasia (TD) is an intractable disease designated by Ministry of Welfare, Health and Labor of Japan, causing severe abnormalities of bones and the brain.

17 Mar 2017

SETD8 enzyme protects against cellular senescence, research reveals

An enzyme that blocks cellular senescence and its mechanisms has been discovered by a research team from Kumamoto University, Japan. They found that a reduction of the enzyme SETD8, which regulates cell proliferation and gene function, results in the promotion of cell aging features.

8 Mar 2017

Study provides insights into how cancer cells can evade FGFR inhibitors

A new study by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibitors.

2 Mar 2017