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Dapagliflozin more effective than sitagliptin for adult patients with type 2 diabetes

Bristol-Myers Squibb Company and AstraZeneca today announced results from a Phase 3 clinical study that showed the investigational compound dapagliflozin 10 mg demonstrated significant reductions in blood sugar levels (glycosylated hemoglobin levels, or HbA1c) compared with placebo at 24 weeks when either agent was added to existing sitagliptin therapy (with or without metformin) in adult patients with type 2 diabetes.

11 Jun 2012

Researchers identify new mitochondrial protein complex linked with type 2 diabetes

Researchers at Metabolic Solutions Development Company, LLC (MSDC) have identified a mitochondrial protein complex through which anti-diabetic drugs exert their insulin sensitizing effects when used to treat patients diagnosed with type 2 diabetes.

11 Jun 2012

Sanofi’s Lantus more effective than sitagliptin for people with type 2 diabetes

Sanofi announced today that people with early type 2 diabetes uncontrolled on metformin demonstrated superior HbA1c - glycated hemoglobin - reduction with Lantus (insulin glargine [rDNA origin] injection) versus sitagliptin.

11 Jun 2012

Incyte, Lilly announce 12-week results from baricitinib Phase IIb study on RA

Eli Lilly and Company and Incyte Corporation announced the presentation of 12-week results from a Phase IIb study of baricitinib, formerly LY3009104 (INCB28050), an orally available janus kinase (JAK) inhibitor, in patients with active rheumatoid arthritis.

11 Jun 2012

Researchers shed light on key biological events that may lead to new disease treatments

In exploring how proteins interact with crucial DNA sequences to regulate gene activity, researchers have shed light on key biological events that may eventually be manipulated to provide new disease treatments.

8 Jun 2012

Study assesses impact of postoperative nHb and transfusion in patients with PAD

Vascular surgeons from Baylor College of Medicine and the Michael E. DeBakey Veterans' Administration Medical Center in Houston, TX, have released a study about the impact of transfusion and postoperative nadir postoperative hemoglobin (nHb) on short- and long-term outcomes after interventions for peripheral arterial disease.

8 Jun 2012

Millions of pre-diabetic Americans may be at increased risk of future stroke

Millions of pre-diabetic Americans may be at increased risk of future stroke, say researchers at the University of California, San Diego School of Medicine in a new meta-analysis of epidemiological studies, but the precise degree of that threat is confounded by differing medical definitions and factors that remain unknown or unmeasured.

8 Jun 2012

GLP-1 receptor agonist boosts glycemic control in Asian patients

Adding once-daily lixisenatide to basal insulin treatment is effective at improving glycemic control in Asian patients with Type 2 diabetes, show study findings.

6 Jun 2012

MBC receives $50,000 FABC grant to further research into blood donor safety

Memorial Blood Centers (MBC), a national leader in transfusion medicine, today announced the receipt of a $50,000 grant from The Foundation for America's Blood Centers (FABC) that will further research into blood donor safety.

6 Jun 2012

Exelixis reports positive interim data from cabozantinib phase 2 trial on HCC

Exelixis, Inc. today reported positive updated interim data from the cohort of hepatocellular carcinoma (HCC) patients participating in the ongoing phase 2 randomized discontinuation trial (RDT) of cabozantinib.

4 Jun 2012

Glucocorticoid steroids in intelligent medicine specifically hits relevant cells

Scientists at Aarhus University, Denmark in collaboration with the biotech company Cytoguide now publish a key to use glucocorticoid steroids in a kind of intelligent medicine that specifically hits the relevant cells. Data are based on rodent studies but if this principle is translated to humans it may greatly improve todays hazardous treatment with this type of potent steroids.

1 Jun 2012

Intensive wellness program addresses multiple aspects of diabetes care

An integrated wellness team approach to diabetes care is helping patients lower their prescription costs and improve their condition, according to research presented today at the American Association of Clinical Endocrinologists' (AACE) 21st Annual Scientific & Clinical Congress in Philadelphia.

28 May 2012

ESRD patients with diabetes may benefit from Baxter’s low-glucose PD regimen

Baxter International Inc. today announced results from two large, international multicenter trials demonstrating that a low glucose peritoneal dialysis (PD) regimen favorably impacted metabolic measures important for end-stage renal disease (ESRD) patients with diabetes, including blood glucose (sugar) control and selected lipids.

From Baxter International Inc. 28 May 2012

EMA CHMP adopts positive opinion for Pfizer’s axitinib to treat advanced renal cell carcinoma

Pfizer announced today that the Committee for Human Medicinal Products (CHMP) of the European Medicines Agency (EMA) has adopted a positive opinion regarding the marketing authorization of axitinib in the European Union (EU), for the treatment of adult patients with advanced renal cell carcinoma (RCC), a type of advanced kidney cancer, after failure of prior treatment with sunitinib or a cytokine.

25 May 2012

Linagliptin safe and effective for African American patients with type 2 diabetes

Boehringer Ingelheim Pharmaceuticals, Inc. and Eli Lilly and Company today announced Phase 3 study results for linagliptin 5 mg once-daily, which showed significant hemoglobin A1c (HbA1c or A1C) reduction of 0.88 percent compared to 0.24 percent in the placebo group (p=0.0002) at 24 weeks in black or African American adult patients with type 2 diabetes whose blood sugar was not adequately controlled.

25 May 2012

Severity of nocturnal hypoxemia and SDB independently predict both T2DM and HbA1c levels

The severity of sleep disordered breathing and nocturnal hypoxemia independently predict both glycosylated hemoglobin (HbA1c) levels and type 2 diabetes mellitus (T2DM), according to a new study.

24 May 2012

New optical microscope sees individual blood cells as they flow inside the body

Blood tests convey vital medical information, but the sight of a needle often causes anxiety and results take time. A new device developed by a team of researchers in Israel, however, can reveal much the same information as traditional blood test in real-time, simply by shining a light through the skin.

21 May 2012

Masimo's RRa provides similar respiration rate accuracy as capnometry for extubated patients

Masimo announced today a new study published in the May 2012 edition of the British Journal of Anaesthesia demonstrates that Masimo's acoustic respiration rate (RRa) from rainbow Acoustic Monitoring provides similar respiration rate accuracy as capnometry for extubated patients.

19 May 2012

Medgenics’ EPODURE receives FDA clearance to proceed into clinical trials

Medgenics, Inc., developer of the novel Biopump technology for the sustained production and delivery of therapeutic proteins in patients using their own tissue, today announced receipt of clearance from the U.S. Food and Drug Administration to proceed with a Phase IIb clinical trial of EPODURE for the treatment of anemia in patients undergoing renal dialysis.

18 May 2012

Micronutrients, early food supplementation during pregnancy improve survival of newborns

Pregnant women in poor communities in Bangladesh who received multiple micronutrients, including iron and folic acid combined with early food supplementation, had substantially improved survival of their newborns, compared to women in a standard program that included usual food supplementation, according to a study in the May 16 issue of JAMA, a theme issue on Global Health.

16 May 2012

Hemoglobin News and Research

Dapagliflozin more effective than sitagliptin for adult patients with type 2 diabetes

Researchers identify new mitochondrial protein complex linked with type 2 diabetes

Sanofi’s Lantus more effective than sitagliptin for people with type 2 diabetes

Incyte, Lilly announce 12-week results from baricitinib Phase IIb study on RA

Researchers shed light on key biological events that may lead to new disease treatments

Study assesses impact of postoperative nHb and transfusion in patients with PAD

Millions of pre-diabetic Americans may be at increased risk of future stroke

GLP-1 receptor agonist boosts glycemic control in Asian patients

MBC receives $50,000 FABC grant to further research into blood donor safety

Exelixis reports positive interim data from cabozantinib phase 2 trial on HCC

Glucocorticoid steroids in intelligent medicine specifically hits relevant cells

Intensive wellness program addresses multiple aspects of diabetes care

ESRD patients with diabetes may benefit from Baxter’s low-glucose PD regimen

EMA CHMP adopts positive opinion for Pfizer’s axitinib to treat advanced renal cell carcinoma

Linagliptin safe and effective for African American patients with type 2 diabetes

Severity of nocturnal hypoxemia and SDB independently predict both T2DM and HbA1c levels

New optical microscope sees individual blood cells as they flow inside the body

Masimo's RRa provides similar respiration rate accuracy as capnometry for extubated patients

Medgenics’ EPODURE receives FDA clearance to proceed into clinical trials

Micronutrients, early food supplementation during pregnancy improve survival of newborns

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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