Immunohistochemistry News and Research

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Immunohistochemistry (IHC) is an imaging technique to visualize antigens in cells. Labeled antibodies bind to target antigens in the cell to image the distribution and localization of specific proteins of interest

Study suggests lingering coronavirus in tissues may contribute to long COVID symptoms

Study investigated whether SARS-CoV-2 lingers in tissues after COVID-19 recovery and if it's linked to long COVID symptoms. They found viral RNA in various organs, and its presence correlated with long COVID symptoms.

25 Apr 2024

DELiVR's virtual reality training speeds up cell detection in complex brain datasets

Efficient neuronal activity detection in brain imaging.

25 Apr 2024

New AI tool 'TORCH' successfully identifies cancer origins in unknown primary cases

A deep-learning approach for tumor origin differentiation using cytological histology.

19 Apr 2024

Periostin may be a novel therapeutic target for treating esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) accounts for around 90% of esophageal cancers, especially in East Asia.

9 Apr 2024

Focusing on oncogenic driver mutations and resistance mechanisms in the treatment of NSCLC

Lung cancer is the leading cause of cancer-related death worldwide. Improved understanding of driver mutations of non-small cell lung cancer (NSCLC) has led to more biomarker-directed treatment for patients with advanced stages.

26 Mar 2024

Towards better diagnosis of neurodegenerative disorders: Skin biopsy for α-synuclein detection proves effective

The positivity rate of cutaneous phosphorylated alpha-synuclein protein (P-SYN) deposition among individuals with dementia.

26 Mar 2024

Choosing the right fat for keto diets: Fish oil's significant role in cancer prevention

The anti-cancer efficacy of different oils consumed as a part of ketogenic diets (KDs).

11 Mar 2024

COVID-19's neurological effects linked to immune response, not direct viral attack

Study identifies neurocognitive symptoms in COVID-19 patients as a reaction to systemic infection rather than direct brain infection, highlighting changes in the brain's immune response and synaptic organization.

21 Feb 2024

Canagliflozin reduces atherosclerosis and modulates inflammatory, oxidative pathways in mice

Announcing a new article publication for Cardiovascular Innovations and Applications journal. This study was aimed at investigating the effect of canagliflozin (Cana) on atherosclerosis and further exploring its potential mechanism. ApoE−/− mice were fed a Western diet (WD) and randomly divided into a WD group and WD+Cana group.

19 Feb 2024

Cytokine interferon-gamma can be a disease-modifying therapeutic target in multiple system atrophy

Multiple system atrophy is a rare and fatal neurodegenerative disease, where insoluble inclusions of the protein alpha-synuclein appear in oligodendrocyte cells of the brain.

12 Feb 2024

CDC releases new syphilis testing guidelines to combat rising cases

The CDC's new guidelines in the Morbidity and Mortality Weekly Report outline comprehensive testing protocols for syphilis diagnosis, emphasizing the combined use of nontreponemal and treponemal tests to improve detection and management of the disease in the U.S.

11 Feb 2024

New cervical cancer detection method promises to reduce unnecessary screenings

The BMC Medicine study introduces the CerMe detection method, using PCDHGB7 hypermethylation to effectively triage high-risk HPV-positive women, potentially reducing unnecessary colposcopy referrals.

8 Feb 2024

Immune protein Ku70 key in fighting bowel cancer

Study establishes Ku70's role in tumor suppression, showing that reduced expression or mutations in this DNA repair protein significantly increase intestinal cancer risk.

30 Jan 2024

Study reveals mangos attenuates potential against colon cancer

The chemo-preventive potential of Mangiferin (MF) (mango).

10 Jan 2024

Gut microbiota linked to social anxiety behaviors

Study reveals that gut microbiota from individuals with social anxiety disorder (SAD) can induce social fear behaviors in mice, suggesting a causal role of gut microbes in modulating behaviors relevant to SAD.

2 Jan 2024

How immune cells shape our earliest breaths

Study profiles the development of immune cells in human lungs during embryonic and fetal stages, revealing their influence on epithelial cell fate and lung development.

1 Jan 2024

New study expands immunotherapy eligibility for colorectal and endometrial cancer patients

A new study shows thousands more patients diagnosed with colorectal and endometrial cancers could benefit from immunotherapy than are currently offered it.

29 Dec 2023

Next-gen sequencing identifies thousands of cancer patients missing out on immunotherapy

Brigham researchers' findings from next-generation sequencing suggest that revising current cancer care guidelines could allow approximately 6,000 more patients in the U.S. to benefit from immunotherapy treatment each year

28 Dec 2023

Autopsy study provides new insights into yellow fever's impact on the heart

To fill gaps in knowledge of yellow fever (YF), a group of researchers in Brazil affiliated with the Department of Pathology at the University of São Paulo's Medical School (FM-USP), Hospital das Clínicas (HC, the hospital complex run by FM-USP), the Heart Institute (InCor, linked to HC) and Emílio Ribas Institute of Infectious Diseases (IIER) decided to study the pathogenesis of YF-associated heart injury.

19 Dec 2023

Organoid study opens new avenues in pulmonary neuroendocrine cancer therapy

Researchers performed a molecular analysis of neuroendocrine neoplasm (NEN) patient-derived tumor organoids (PDTOs) and their parental neoplasms.

13 Dec 2023