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Insulin is a hormone that is needed to convert glucose, starches and other food into energy needed for daily life. Insulin allows cells to use glucose for fuel and is secreted by beta cells in the islets of Langerhans. The release of insulin from the pancreas is stimulated by increased blood glucose, vagal nerve stimulation, and other factors. Insulin is obtained from various animals and available in a variety of preparations. Commercial insulin preparations differ in a number of ways, including differences in the animal species from which they are obtained; their purity, concentration, and solubility; and the time of onset and duration of their biologic action. An oral hypoglycemic agent is not a form of insulin therapy.
One million serious medical complications could be avoided with improvements in blood glucose levels in diabetics

One million serious medical complications could be avoided with improvements in blood glucose levels in diabetics

Sanofi, Diabetes UK and JDRF today announce the publication of IMPACT 2 in the journal Diabetic Medicine. This new study shows that, if sustained, even modest improvement in blood glucose levels can provide significantly improved outcomes for the 3.5 million people diagnosed with diabetes in the UK. [More]
Potential treatment target identified for fatty liver disease

Potential treatment target identified for fatty liver disease

Two proteins, p38 gamma and p38 delta, control the accumulation of fat in the liver, a process linked to the development of insulin resistance and diabetes, which are common outcomes of obesity. These findings are presented in an article published by researchers at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC). [More]
American Diabetes Association issues statement to address diabetes management in LTC facilities

American Diabetes Association issues statement to address diabetes management in LTC facilities

The care of adults over age 65 with type 2 diabetes is a growing concern: the prevalence of diabetes is highest in this age group and is expected to grow as the U.S. population ages, with many needing care at long-term care (LTC) facilities. [More]
Height affects risk of major non-communicable diseases

Height affects risk of major non-communicable diseases

Height is largely genetically determined, but in recent decades the height of children and adults has steadily increased throughout the world: In adulthood the children are almost always significantly taller than their parents. [More]
Understanding crucial role of 'healthy' brain in preventing memory failures linked to Alzheimer's disease

Understanding crucial role of 'healthy' brain in preventing memory failures linked to Alzheimer's disease

The mechanisms underlying the stability and plasticity of neural circuits in the hippocampus, the part of the brain responsible for spatial memory and the memory of everyday facts and events, has been a major focus of study in the field of neuroscience. Understanding precisely how a "healthy" brain stores and processes information is crucial to preventing and reversing the memory failures associated with Alzheimer's disease (AD), the most common form of late-life dementia. [More]
Maternal diet during pregnancy and lactation leads to epigenetic changes in offspring

Maternal diet during pregnancy and lactation leads to epigenetic changes in offspring

As the study shows, a high-fat diet during pregnancy and lactation leads to epigenetic changes in the offspring. These changes affect metabolic pathways regulated by the gut hormone GIP, whereby the adult offspring are more susceptible to obesity and insulin resistance, the precursor to type 2 diabetes. Similar mechanisms cannot be ruled out in humans, according to Pfeiffer. [More]
Irregular sleep schedules linked to adverse metabolic health in midlife women

Irregular sleep schedules linked to adverse metabolic health in midlife women

A new study suggests that frequent shifts in sleep timing may be related to adverse metabolic health among non-shift working, midlife women. [More]
Alternative splicing: a new approach to drug development? An interview with Lucy Donaldson

Alternative splicing: a new approach to drug development? An interview with Lucy Donaldson

RNA is becoming an interesting drug target as it takes possible intervention back one step to the synthesis of a target protein, instead of trying to block or inhibit a process. [More]
Weight loss programs that provide healthy fats have similar impacts on pound-shedding

Weight loss programs that provide healthy fats have similar impacts on pound-shedding

A University of California, San Diego School of Medicine study finds that weight loss programs that provide healthy fats, such as olive oil in the Mediterranean diet, or a low-fat, high-carbohydrate diet have similar impacts on pound-shedding. [More]
Second-hand smoke exposure linked to larger waist, poorer cognition in children

Second-hand smoke exposure linked to larger waist, poorer cognition in children

Exposure to second-hand smoke is associated with a larger waist and poorer cognition in children, researchers say. [More]
Study finds possibility of targeting Orai3 as novel treatment for obesity-related inflammation

Study finds possibility of targeting Orai3 as novel treatment for obesity-related inflammation

A new study by a team of Rosalind Franklin University researchers headed by Carl White, PhD, assistant professor of physiology and biophysics, has discovered that the degree of chronic inflammation caused by obesity is highly dependent on levels of the signaling molecule, hydrogen sulfide, which alters the activity of a calcium channel, Orai3. [More]
Lilly receives FDA approval for Humulin R U-500 KwikPen

Lilly receives FDA approval for Humulin R U-500 KwikPen

The U.S. Food and Drug Administration has approved Eli Lilly and Company's Humulin R U-500 KwikPen(insulin human injection) 500 units/mL, a pre-filled device containing Humulin R U-500, a highly concentrated formulation of insulin. [More]
Findings may explain why type 2 diabetic patients experience smelling problems

Findings may explain why type 2 diabetic patients experience smelling problems

In a study in type 2 diabetic rats, researchers at the Karolinska Institutet have identified alterations in specific nerve cells that are important for odor identification. The findings might explain why type 2 diabetic patients often experience smelling problems and potentially open up a new research field to develop preventive therapies against neurodegenerative diseases in type 2 diabetic patients. [More]
Weekend junk food binges bad for your gut health

Weekend junk food binges bad for your gut health

Yo-yoing between eating well during the week and bingeing on junk food over the weekend is likely to be just as bad for your gut health as a consistent diet of junk, new UNSW research suggests. [More]
Short bursts of intensive exercise could be more effective in preventing Type 2 diabetes

Short bursts of intensive exercise could be more effective in preventing Type 2 diabetes

Short bursts of intensive exercise provide a more "time-efficient" and realistic way of preventing, delaying and managing Type 2 diabetes and also losing weight, a study has found. [More]
New study shows 92% of measured restaurant meals exceed calorie requirements

New study shows 92% of measured restaurant meals exceed calorie requirements

Meals consumed at fast-food restaurants are often seen as one of the biggest contributors to the obesity epidemic. But according to a new study in the Journal of the American Academy of Nutrition and Dietetics, 92 percent of 364 measured restaurant meals from both large-chain and non-chain (local) restaurants exceeded recommended calorie requirements for a single meal. [More]
Artificial pancreas moves closer to becoming a reality

Artificial pancreas moves closer to becoming a reality

As the accuracy, reliability, adoption, and successful use of Continuous Glucose Monitoring (CGM) continue to increase, the ultimate goal of combining CGM with an insulin pump and sophisticated algorithms for automating the control and suspension of insulin infusion--known as the "artificial pancreas"--moves closer to becoming a reality. [More]
Extended weekend sleep can counteract increased risk of diabetes associated with sleep loss

Extended weekend sleep can counteract increased risk of diabetes associated with sleep loss

Two consecutive nights of extended sleep, a typical weekend occurrence, appears to counteract the increased risk of diabetes associated with short-term sleep restriction during the work week, at least in lean, healthy, young men eating a controlled diet. [More]
Insulet donates $10,000 each to ADA and JDRF to improve lives of people living with diabetes

Insulet donates $10,000 each to ADA and JDRF to improve lives of people living with diabetes

Insulet Corporation, the leader in tubeless insulin pump technology with its OmniPod Insulin Management System, today announced that is has donated $10,000 each to the American Diabetes Association and the Juvenile Diabetes Research Foundation. [More]
Researchers reveal biological connection between obesity and colorectal cancer risk

Researchers reveal biological connection between obesity and colorectal cancer risk

Obesity has long been associated with increased risk of colorectal cancer, but the link has never been understood. Now, a research team led by investigators at Thomas Jefferson University has revealed the biological connection, and in the process, has identified an approved drug that might prevent development of the cancer. [More]
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