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Insulin is a hormone that is needed to convert glucose, starches and other food into energy needed for daily life. Insulin allows cells to use glucose for fuel and is secreted by beta cells in the islets of Langerhans. The release of insulin from the pancreas is stimulated by increased blood glucose, vagal nerve stimulation, and other factors. Insulin is obtained from various animals and available in a variety of preparations. Commercial insulin preparations differ in a number of ways, including differences in the animal species from which they are obtained; their purity, concentration, and solubility; and the time of onset and duration of their biologic action. An oral hypoglycemic agent is not a form of insulin therapy.
Rat study finds maternal intake of oxidised fish oil causes high newborn mortality

Rat study finds maternal intake of oxidised fish oil causes high newborn mortality

Nearly 30 percent of newborn pups born to pregnant rats fed highly oxidized ("off") fish oil died within two days after birth a new study by researchers at the Liggins Institute at the University of Auckland in New Zealand finds. [More]
Study suggests failure of specialised beta cells may lead to diabetes

Study suggests failure of specialised beta cells may lead to diabetes

The significant role of beta cell 'hubs' in the pancreas has been demonstrated for the first time, suggesting that diabetes may due to the failure of a privileged few cells, rather than the behaviour of all cells. [More]
Risk of hypoglycemia differs between SU agents, study reveals

Risk of hypoglycemia differs between SU agents, study reveals

Adding sulphonylureas (SUs) to metformin remains a commonly used strategy for treating type 2 diabetes, but individual SUs differ and may confer different risks of abnormally low blood sugar, or hypoglycemia. SUs-which include newer generation agents such as gliclazide, glipizide, glimepiride, and glibenclamide-stimulate the production of insulin in the pancreas and increase the effectiveness of insulin in the body. [More]
Breastfeeding leads to long-term metabolic changes in mothers, study shows

Breastfeeding leads to long-term metabolic changes in mothers, study shows

An interdisciplinary team of scientists at the Helmholtz Zentrum M√ľnchen has studied the metabolism of women with gestational diabetes after giving birth. [More]
Eating more healthy fats may lower type 2 diabetes risk

Eating more healthy fats may lower type 2 diabetes risk

Eating more unsaturated fats, especially polyunsaturated fats, in place of either dietary carbohydrate or saturated fats lowers blood sugar levels and improves insulin resistance and secretion, according to a new meta-analysis of data from 102 randomised controlled feeding trials in adults. [More]
Scientists identify marker that subdivides insulin-producing beta cells of the pancreas

Scientists identify marker that subdivides insulin-producing beta cells of the pancreas

The marker Flattop subdivides the insulin-producing beta cells of the pancreas into those that maintain glucose metabolism and into immature cells that divide more frequently and adapt to metabolic changes. [More]
New report reveals prescription medication costs may increase up to 13% in 2016

New report reveals prescription medication costs may increase up to 13% in 2016

Prescription medication costs are expected to rise at least 11 percent, and possibly up to 13 percent, in 2016, according to a new report on national trends and projections in prescription drug expenditures. [More]
Study reveals muscle activity of non-responders to diabetes interventions

Study reveals muscle activity of non-responders to diabetes interventions

It is widely accepted that physical exercise lowers the risk of developing diabetes. Yet in one in five participants in related studies this positive effect fails to materialize. [More]
Researchers use microfluidic chip to study how adipose stem cells develop into mature fat cells

Researchers use microfluidic chip to study how adipose stem cells develop into mature fat cells

A Freiburg-based research group has developed a microfluidic chip where more than one hundred apidose-derived adult stem cell cultures can grow and divide. In the human body, adipose tissue acts as a primary energy store. [More]
Scientists explore ways to make fat cells function better during obesity

Scientists explore ways to make fat cells function better during obesity

A high-fat diet makes your fat cells larger, inflamed and dysfunctional, putting you at increased risk for diabetes and cardiovascular disease. [More]
Obesity is linked with premature death, particularly in men

Obesity is linked with premature death, particularly in men

Being overweight or obese is associated with an increased risk of premature death, according to the largest ever study into obesity and death. [More]
Changes in cavefish metabolism could lead to new insights into diabetes

Changes in cavefish metabolism could lead to new insights into diabetes

Cavefish that live in dark caves with only sporadic access to food show symptoms similar to diabetes, but don't appear to experience any health problems. [More]
Researchers identify PKD1 protein as potential cause for impaired insulin signaling in diabetics

Researchers identify PKD1 protein as potential cause for impaired insulin signaling in diabetics

Medication can help trigger the enzyme that kick starts insulin production in the body, but the drugs don't always work for those who are obese or diabetic, and most need to regulate their glucose and insulin levels. That's why a recent discovery made by Rudy Valentine and a team of researchers holds so much promise. [More]
Research on Flattop protein could provide starting point for regenerative diabetes therapies

Research on Flattop protein could provide starting point for regenerative diabetes therapies

The marker Flattop subdivides the insulin-producing beta cells of the pancreas into those that maintain glucose metabolism and into immature cells that divide more frequently and adapt to metabolic changes. [More]
Manipulation of gut microbes can reverse negative effects of high fat diet, researchers find

Manipulation of gut microbes can reverse negative effects of high fat diet, researchers find

Did you know that your gut sends neural messages to the brain to tell it when it is full? Researchers at the University of Georgia, Binghamton University, and Pennsylvania State University have now found that chronic consumption of high fat foods disturbs these neural messages in rats by shifting the populations of bacteria that ordinarily reside inside the gut. [More]
CNIO study shows proinflammatory molecule IL-17A can be key factor in development of NASH and HCC

CNIO study shows proinflammatory molecule IL-17A can be key factor in development of NASH and HCC

Non-alcoholic steatohepatitis (NASH) is a serious hepatic condition that precedes hepatocellular carcinoma (HCC) and is currently untreatable. [More]
New study identifies four subtypes of human insulin producing beta cells involved in diabetes

New study identifies four subtypes of human insulin producing beta cells involved in diabetes

A new study led by nationally prominent stem cell scientist Markus Grompe, M.D., has determined the existence of at least four separate subtypes of human insulin producing beta cells that may be important in the understanding and treatment of diabetes. The findings were published online today in the journal Nature Communications. [More]
New study suggests potential role for gut microbiota in diabetes remission after bypass surgery

New study suggests potential role for gut microbiota in diabetes remission after bypass surgery

Studies have shown that bariatric surgery can lead to remission of type 2 diabetes mellitus (T2DM) in rodents and humans, but this beneficial effect cannot be explained solely by weight loss. [More]
Mussels inspire scientists to attach biologically active molecule to titanium surface

Mussels inspire scientists to attach biologically active molecule to titanium surface

Titanium is used medically in applications such as artificial joints and dental implants. While it is strong and is not harmful to tissues, the metal lacks some of the beneficial biological properties of natural tissues such as bones and natural teeth. [More]
Study estimates global trends in diabetes prevalence

Study estimates global trends in diabetes prevalence

A female researcher from UPM is involved in a study that estimates the global prevalence of diabetes and anticipates future trends. [More]
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