The proinsulin precursor of insulin is encoded by the ''INS'' gene.
Alleles
A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region.
| Regulatory sequence
| binding transcription factors
|
| ILPR
| Par1
|
| A5
| Pdx1
|
| negative regulatory element (NRE)
| glucocorticoid receptor, Oct1
|
| Z (overlapping NRE and C2)
| ISF
|
| C2
| Pax4, MafA(?)
|
| E2
| USF1/USF2
|
| A3
| Pdx1
|
| CREB RE
| -
|
| CREB RE
| CREB, CREM
|
| A2
| -
|
| CAAT enhancer binding (CEB) (partly overlapping A2 and C1)
| -
|
| C1
| -
|
| E1
| E2A, NeuroD1, HEB
|
| A1
| Pdx1
|
| G1.
|
Further Reading
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"Insulin"
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