Lysosomes News and Research

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Oral pathogen linked to increased risk of heart rupture after heart attack

Researchers from Tokyo Medical and Dental University(TMDU) find that a periodontal pathogen, Porphyromonas gingivalis, inhibits autophagosome–lysosome fusion, and can therefore worsen cardiac remodeling and cause cardiac rupture after myocardial infarction.

19 Oct 2023

Intracellular journey: The penetration of antidepressants into cells, organelles, and membranes

Researchers in neuropsychopharmacology challenge conventional wisdom about antidepressants' actions, revealing significant intracellular activity that influences their effectiveness. Utilizing advanced technologies, the study prompts a reevaluation of drug targeting and mechanisms, opening new avenues for treating depression.

12 Oct 2023

Study discovers a new endocytic pathway in budding yeast

Endocytosis is an important cellular process through which cells internalize substances such as water and nutrients.

25 Sep 2023

New anticancer treatment technology targets cancer cell lysosomes and overcomes drug resistance

A groundbreaking anticancer treatment technology that selectively targets cancer cell lysosomes and overcomes drug resistance has been developed by Professor Ja-Hyoung Ryu and his research team in the Department of Chemistry at UNIST.

22 Sep 2023

New gene variant linked to Parkinson's disease found in people of African ancestry

A gene variant found almost exclusively in the genomes of people of African ancestry increases the risk of developing Parkinson's disease, according to an international study of nearly 198,000 participants with this genetic background.

23 Aug 2023

New insights into the pathogenic mechanisms of SLC29A3 disorders

In humans, the SLC29A3 gene regulates the function of lysosomes to control waste recycling in cells such as macrophages (that engulf and destroy foreign bodies).

22 Aug 2023

Machine learning can accurately predict subtypes of Parkinson's disease

Researchers at the Francis Crick Institute and UCL Queen Square Institute of Neurology, working with technology company Faculty AI, have shown that machine learning can accurately predict subtypes of Parkinson's disease using images of patient-derived stem cells.

10 Aug 2023

How conversion between different types of cell death contributes to disease

Researchers elucidate the role of cell death in the pathogenesis of different diseases.

10 Aug 2023

Nanotechnology's triple threat: Advancing precision cancer treatment

The design of tumor tissue-, cell-, and organelle-targeted cancer nanomedicines.

9 Aug 2023

New protein discovered in Alzheimer's brains could lead to better diagnosis and treatment

Alzheimer's is considered a disease of old age, with most people being diagnosed after 65. But the condition actually begins developing out of sight many years before any symptoms emerge.

19 Jul 2023

Northwestern Medicine scientists discover new therapeutic target for Parkinson’s disease

Northwestern Medicine scientists have uncovered a new mechanism by which mutations in a gene parkin contribute to familial forms of Parkinson's disease.

19 Jul 2023

Insilico Medicine and MIKADO team up to find new treatments for cystinosis

A team led by researchers at the Mechanisms of Inherited Kidney Disorders (MIKADO) group at the University of Zurich (Zurich, Switzerland) has used Insilico Medicine's generative artificial intelligence (AI) target discovery engine, PandaOmics, to identify actionable drug targets for the lysosomal storage disease cystinosis and to validate them in preclinical models of the disease.

14 Jul 2023

AI-powered drug discovery offers hope for cystinosis patients

Artificial intelligence is becoming increasingly important in drug discovery. Advances in the use of Big Data, learning algorithms and powerful computers have now enabled researchers at the University of Zurich (UZH) to better understand a serious metabolic disease.

14 Jul 2023

Scientists discover new mechanism for kidney cell renewal

University of Texas at Dallas scientists have discovered a previously unknown "housekeeping" process in kidney cells that ejects unwanted content, resulting in cells that rejuvenate themselves and remain functioning and healthy.

14 Jul 2023

Study provides insights into the molecular mechanism of Batten disease

Neuronal Ceroid Lipofuscinosis are a group of devastating neurodegenerative lysosomal storage disorders that begin in childhood. Mutations in CLN3 gene lead to a NCL called Batten disease, characterized by the progressive loss of vision, movement, and cognition.

6 Jul 2023

Lysosomes News and Research

Oral pathogen linked to increased risk of heart rupture after heart attack

Intracellular journey: The penetration of antidepressants into cells, organelles, and membranes

Study discovers a new endocytic pathway in budding yeast

New anticancer treatment technology targets cancer cell lysosomes and overcomes drug resistance

New gene variant linked to Parkinson's disease found in people of African ancestry

New insights into the pathogenic mechanisms of SLC29A3 disorders

Machine learning can accurately predict subtypes of Parkinson's disease

How conversion between different types of cell death contributes to disease

Nanotechnology's triple threat: Advancing precision cancer treatment

New protein discovered in Alzheimer's brains could lead to better diagnosis and treatment

Northwestern Medicine scientists discover new therapeutic target for Parkinson’s disease

Insilico Medicine and MIKADO team up to find new treatments for cystinosis

AI-powered drug discovery offers hope for cystinosis patients

Scientists discover new mechanism for kidney cell renewal

Study provides insights into the molecular mechanism of Batten disease

RNA plays a role in regulating cell fate in the early mouse embryo

Study highlights two strategies used by Salmonella to escape the human body's defenses

Extracellular chaperones mediate the lysosomal degradation of misfolded proteins

Novel fluorescent probe reveals constant conversion rate of endolysosomes

UC-led research team receives NIH grant to study the role of an enzyme in lysosome function

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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