Metabolite News and Research

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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

Compound derived from fruit and vegetables could be used to improve the effects of an established cancer drug

The drug, mitomycin C (MMC), is a well-known anticancer treatment used mainly against solid tumours in the bladder and lower bowel. It is activated by enzymes naturally found in the human body, but its use is limited by severe side effects at higher doses.

5 Oct 2004

New technique offers efficient blood cleansing

Blood poisoning is fatal in almost half of all cases. Patients could be helped by efficient blood cleansing. Scientists are working on a new technique that will quickly and effectively retrieve toxic substances from the vital fluid without altering the blood count.

4 Oct 2004

Chemical pathways of serotonin in the nervous system pave way for future pharmaceutical treatments for depression

From mollusks to mammals, newly discovered chemical pathways of serotonin in the nervous system are paving a path toward future pharmaceutical treatments for depression and other disorders.

10 Sep 2004

Existing hepatitis drug could lead to the development of new drugs for the treatment of anthrax

Thanks to new screening tools, and some luck, researchers at the University of Chicago have discovered three unrelated compounds that inhibit the two toxins – edema factor and lethal factor -- that have made anthrax one of the most feared of potential bioterror agents.

21 Aug 2004

New service-oriented laboratory focused on bioanalysis and pharmacokinetics

Oregon Health & Science University researchers will more quickly move benchtop discoveries toward drug discoveries with the help of a new, service-oriented laboratory focused on bioanalysis and pharmacokinetics.

11 Aug 2004

Organic tomatoes have higher levels of vitamin C

In her study of organic and conventionally grown tomatoes, Alyson Mitchell, a food chemist at University of California at Davis, found organic tomatoes had higher levels of secondary plant metabolites and higher levels of vitamin C.

26 Jul 2004

The Phthalate Esters Panel responds to claims about the health effects of phthalates

A new report by Environment California Research & Policy Center makes several claims about the health effects of phthalates contained in consumer products that are unsupported by the science.

25 Jun 2004

Cutting down on cigarettes may actually increase consumption of smoke, carbon monoxide and nicotine

Smokers who pride themselves on successfully cutting back as a step toward quitting tobacco altogether may be caught in a haze of self-deception.

21 Jun 2004

Only half of gemcitabine dose may be activated in cancer patients

The study, presented in a poster discussion session by Jason Fisher, a student at the University of Pittsburgh School of Engineering, analyzed data from 31 cancer patients given 30-minute infusions of gemcitabine to determine what percentage of the drug dose was associated with concentrations that exceeded the body's ability to activate the drug.

9 Jun 2004

Research laboratory at the forefront of the science of metabolomics

A new $1.8 million research laboratory will catapult Iowa State University to the forefront of the science of metabolomics.

2 Jun 2004

Morphine does not alleviate acute pain in preterm neonates

Preterm neonates undergo many painful procedures as part of their standard care in the Neonatal Intensive Care Unit (NICU). Preterm babies are able to experience pain and indeed are highly sensitive to it.

2 May 2004

Researchers examine community-based drinkers rather than abstinent alcoholics

Almost all knowledge about brain damage due to chronic alcohol consumption has been gathered from alcoholics, who have generally been studied toward the end of their institutionalized treatment program (several weeks after their last drink) or many months into abstinence.

13 Apr 2004

Data on pre-clinical activity of satraplatin in prostate cancer to be released

Spectrum Pharmaceuticals, Inc has announced that new data on pre-clinical activity of satraplatin in prostate cancer cell lines are being presented at the 95th Annual Meeting of the American Association for Cancer Research (AACR) in Orlando, Florida.

29 Mar 2004

New Theory About Alzheimer's Disease

A group of scientists at The Scripps Research Institute has proposed a new theory about the cause of Alzheimer's disease, the progressive neurodegenerative disorder that currently afflicts some 4.5 million Americans. According to the hypothesis, the disease arises as a consequence of inflammation, which creates abnormal metabolites out of normal brain molecules.

22 Mar 2004