Spectrum Pharmaceuticals, Inc has announced that new data on pre-clinical activity of satraplatin in prostate cancer cell lines are being presented at the 95th Annual Meeting of the American Association for Cancer Research (AACR) in Orlando, Florida. Spectrum Pharmaceuticals' co-development partner for satraplatin, GPC Biotech AG, will present abstract #4614 entitled "Cytotoxic activity of satraplatin (JM216) and its metabolites in human prostate carcinoma cell lines" on March 30, 2004. "The data on satraplatin, to be presented at one of the key scientific meetings in the field of cancer research, continues to be supportive of the clinical development of satraplatin for the treatment of hormone-refractory prostate cancer," stated Rajesh C. Shrotriya, M.D., Chairman, Chief Executive Officer and President of Spectrum Pharmaceuticals, Inc.
Satraplatin was tested in three human prostate cancer cell lines, two androgen-independent (i.e., hormone refractory) and one androgen-sensitive (i.e., hormone sensitive). Investigators concluded that satraplatin was a potent cytotoxic agent in prostate cancer. Hormone refractory prostate cancer cell lines were more sensitive to satraplatin than the hormone sensitive cell line.
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