Nuclear Magnetic Resonance (NMR) News and Research

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Scientists unravel mystery of T cell signaling process vital to immune response

The immune system cells known as T cells play a central role in the body's ability to fight infections and cancer. For decades, however, details of the molecular signaling process that leads to T cell activation have remained a mystery.

16 May 2017

Novel technique can provide high-resolution profile of molecules inside living organisms

A novel technique developed by University of Toronto Scarborough researchers can for the first time get a high-resolution profile of which molecules are present inside a living organism.

2 May 2017

NovAliX's new laboratory to use cryo-TEM for facilitating small molecule and biologic drug discovery

A new contract research laboratory operated by France-based NovAliX will provide pharmaceutical companies with access to high-resolution cryo-transmission electron microscopy (cryo-TEM) by Thermo Fisher Scientific for facilitating small molecule and biologic drug discovery.

3 Mar 2017

Novel NMR spectroscopy platform holds potential to revolutionize drug development practices

Implementation of a new nuclear magnetic resonance spectroscopy platform will provide professors Nicolas Doucet and Steven LaPlante of Centre INRS-Institut Armand-Frappier with a powerful new tool for conducting an ambitious research program aimed at identifying new therapeutic molecules.

28 Feb 2017

Researchers develop new tool that quickly reveals metabolic fluxes in cells

If we were to take photographs at the underground stations in Barcelona, we would see the number of people waiting, find out what time the rush hour takes place and deduce why some stations are busier than others.

23 Feb 2017

University of Warwick researchers discover molecular phenomenon using solid-state NMR facility

Cutting edge technology has shown a molecule self-assembling into different forms when passing between solution state to solid state, and back again - a curious phenomenon in science - says research by the University of Warwick.

17 Feb 2017

NMR and metabolic phenotyping

In this interview, Dr Harmut Schafer introduces the work being done at the Phenome Center in Birmingham, on metabolic phenotyping using NMR.

From Bruker BioSpin - NMR, EPR and Imaging 31 Jan 2017

Advanced NMR-based methods for studying RNPs and drug design

Nuclear magnetic resonance (NMR) spectroscopy is a powerful analytical tool widely used in chemical research to investigate the structure and dynamics of molecules.

From Bruker BioSpin - NMR, EPR and Imaging 24 Jan 2017

Bruker is to be key International Phenome Centre Network corporate partner for NMR Technologies and SOPs

The International Phenome Centre Network (IPCN), founded by Imperial College London and more than a dozen international partners in Australia, Canada, China, Japan, Singapore, Taiwan, the US, and the UK (www.phenomenetwork.org), was launched officially this week at the 2016 World Innovation Summit for Health (WISH) conference in Doha, Qatar. This global network is a critical link between leading research centers across the world and will support research into some of today’s most pressing global health challenges.

From Bruker 23 Jan 2017

Metabolomics and NMR

Bruker has been involved in the Phenome Center network since its beginning. Several years ago, the whole visionary concept of a global phenome network was actually born with Professor Jeremy Nicholson and Bruker BioSpin has been part of it since the early stages.

From Bruker BioSpin - NMR, EPR and Imaging 17 Jan 2017

New global network to explore link between genes and environmental factors to tackle health challenges

A new global network linking leading research centres across the world has launched today to tackle some of the most pressing global health challenges of our time such as autism, cancer, diabetes and dementia.

1 Dec 2016

Research offers new insights into underlying mechanisms of deadly cystic fibrosis

A minor hiccup in the sequence of a human gene can have devastating impacts on health. Such flaws cause cystic fibrosis (CF), a disease affecting the lungs and other vital organs, often leading to death by the age of 30.

9 Sep 2016

Novel nanoscale display case could help reveal structure of hard-to-study molecules

Researchers at the Department of Energy's Lawrence Berkeley National Laboratory and UC Berkeley have created a sort of nanoscale display case that enables new atomic-scale views of hard-to-study chemical and biological samples.

19 Aug 2016

Small dense HDL particles protectively linked to coronary heart disease risk

The idea that plasma high-density lipoprotein cholesterol (HDL-C) is protective against coronary heart disease has been part of medical conventional wisdom for five decades.

3 Aug 2016

Comprehensive NMR profiling module for detailed lipoprotein subclass analysis announced by Bruker (research use only)

At the 12th Annual Conference of the Metabolomics Society (www.metabolomics2016.org), Bruker announces a new, more comprehensive, more efficient and easy-to-use profiling module for detailed lipoprotein subclass analysis using Nuclear Magnetic Resonance (NMR).

From Bruker BioSpin - NMR, EPR and Imaging 1 Jul 2016

First European fully superconductive coil reaching a magnetic field of 25 Tesla produced

Today, the magnets used in nuclear magnetic resonance (NMR) and medical magnetic resonance imaging (MRI) represent the primary commercial applications of superconductivity. NMR, used mainly in the chemical and pharmaceutical industry, allows discovering new molecules, studying the structure of proteins or analyzing food content. It is essential for drug development or the quality control of chemical compounds.

From Bruker BioSpin - NMR, EPR and Imaging 8 Jun 2016

New study finds alternative approaches to target proteins sustaining cancer, Alzheimer's disease

Drugs to treat cancer and Alzheimer's disease usually target the active sites of specific protein molecules sustaining the disease. Traditional drug design views proteins as rigid 3-D objects with active sites consisting of surface-accessible "pockets" with a specific, well-defined structure.

6 Jun 2016

Unlocking the dark proteome: an interview with Dr Kriwacki

The term dark proteome refers to proteins whose structural features and thus functions are not well understood. Many proteins within the dark proteome do not fold into stable three-dimensional structures. These proteins are called intrinsically disordered proteins (IDPs) and feature highly flexible, disordered confirmations.

16 May 2016

The Weizmann Institute of Science purchases novel Aeon™ 1GHz NMR system from Bruker

The Weizmann Institute of Science in Rehovot, Israel today announced major scientific instrument purchases from Bruker (NASDAQ: BRKR), including a novel Aeon™ 1GHz nuclear magnetic resonance (NMR) system for expanding frontiers in structural biology and intrinsically disordered protein (IDPs) research. Furthermore, the Weizmann Institute is adding an Aeon 600 MHz NMR, a 263 GHz dynamic nuclear polarization (DNP)-NMR system, and a Biospec® 15 Tesla system for preclinical ultra-high field magnetic resonance imaging (MRI). Various NMR and electron paramagnetic resonance (EPR) instrument upgrades round out this major acquisition, instantly propelling the Weizmann Institute to the frontiers of modern magnetic resonance research infrastructure.

From Bruker BioSpin - NMR, EPR and Imaging 11 Apr 2016

FEI, NovAliX to jointly provide cryo-EM-based structural analysis services for pharmaceutical and biotech industry

FEI and NovAliX, a contract research organization (CRO), announced today a strategic partnership to enable NovAliX to provide commercial cryo-electron microscopy (EM)-based structural analysis services to its customers in the pharmaceutical and biotech industry.

From Thermo Fisher Scientific – Electron Microscopy Solutions 23 Mar 2016