Organoids News and Research

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Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.

GTF2I gene's role in Williams syndrome and autism unraveled

Individuals with the neurodevelopmental disorder Williams syndrome have a gregarious "cocktail party" personality, while those with the opposite genetic alteration, in contrast, tend to have autistic traits and are prone to struggle socially.

28 Feb 2024

New lung cell atlas unveils pathways to lung adenocarcinoma development

Researchers at The University of Texas MD Anderson Cancer Center built a new atlas of lung cells, uncovering new cellular pathways and precursors in the development of lung adenocarcinoma, the most common type of lung cancer.

28 Feb 2024

Novel "Tissue-in-a-CUBE" model mimics blood-brain barrier for drug testing

A research team at the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan has succeeded in establishing a model of the blood-brain barrier using modularized tissue derived from human cells.

28 Feb 2024

Novel brain organoid model unveils link between inflammation and astrocyte dysfunction

The brain is typically depicted as a complex web of neurons sending and receiving messages. But neurons only make up half of the human brain.

28 Feb 2024

Study reveals distinct molecular features of proximal and distal colon cancers

The colon is often thought of as one organ, but the right and left parts of the colon have different molecular features in cancers.

27 Feb 2024

Revolutionary stem cell culture method produces full model of human central nervous system

The first stem cell culture method that produces a full model of the early stages of the human central nervous system has been developed by a team of engineers and biologists at the University of Michigan, the Weizmann Institute of Science, and the University of Pennsylvania.

26 Feb 2024

“Laboratory testicles” could solve male infertility mysteries

The testis is responsible for sperm production and testosterone synthesis. Abnormalities in testis development and function lead to disorders of sex development (DSD) and male infertility. Currently, no in vitro system exists for modeling the testis.

20 Feb 2024

New breakthrough in pancreatic cancer research could help slow the disease's deadly spread

Scientists at Cold Spring Harbor Laboratory (CSHL) and the University of California, Davis have reached a new breakthrough in pancreatic cancer research-;eight years in the making. It could help slow the disease's deadly spread.

14 Feb 2024

New drug targets key mechanism in ALS, protects motor neurons

A new pharmacological inhibitor can intervene in a central cell death mechanism that is responsible for the death of motor neurons and hence important for the progression of the motor neuron disease amyotrophic lateral sclerosis (ALS).

8 Feb 2024

Study advances search for a blood test to identify disease-associated changes in the brain

Researchers in a Johns Hopkins Children's Center-led study that used genetic material from human blood and lab-grown brain cells say they have made progress in developing a blood test to identify disease-associated changes in the brain specifically linked to postpartum depression and other psychiatric and neurological disorders.

8 Feb 2024

Study pinpoints a protein linked to metastatic pancreatic cancer

Pancreatic cancer is the No. 3 cause of cancer-related deaths in the United States, and only 12% of patients survive five years after being diagnosed.

7 Feb 2024

Tecan offers end-to-end solutions for cellomics: automated workflows from single-cell dispensing to 3D spheroid analysis

Tecan is proud to offer end-to-end cellomics workflow solutions, including cell seeding and culture with quality control and monitoring, through drug dosing to live-cell imaging and analysis. This comprehensive offering enables laboratories to improve the reliability, reproducibility and throughput of their workflows, addressing key challenges in the growing field of 3D cell biology.

5 Feb 2024

Engrailed-1 protein promotes pancreatic cancer progression and metastasis

Pancreatic cancer is the No. 3 cause of cancer-related deaths in the United States, and only 12% of patients survive five years after being diagnosed.

2 Feb 2024

mRNA therapy revives p53 to combat ovarian tumors

Ovarian cancer is often very aggressive and responds poorly to the therapies currently available. A recent study by Goethe University Frankfurt and University Hospital Frankfurt offers hope that this could change in the medium term.

24 Jan 2024

Lab-grown mini-placentas shed light on pre-eclampsia and pregnancy disorders

Scientists have grown 'mini-placentas' in the lab and used them to shed light on how the placenta develops and interacts with the inner lining of the womb – findings that could help scientists better understand and, in future, potentially treat pre-eclampsia.

17 Jan 2024