Organoids News and Research

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Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.

HUB and Dutch health insurance companies to test use of organoid technology for CF treatment

Hubrecht Organoid Technology (HUB), and the health insurance companies CZ, Zilveren Kruis, and Menzis announced today that they will start a €3 million validation trial for use of HUB Organoid Technology to test if it can be used to determine the response of Cystic Fibrosis (CF) patients to new drug therapies.

9 Jan 2017

Scientists develop 3-D organoid to unravel immune response during infection

What if you could design an adaptable, biomaterials-based model of an organ to track its immune response to any number of maladies, including cancer, transplant rejection and the Zika virus? The lab of Ankur Singh, assistant professor in the Sibley School of Mechanical and Aerospace Engineering, has asked - and begun to answer - that very question.

6 Jan 2017

Scientists use pluripotent stem cells to generate human stomach tissues in laboratory

Scientists report in Nature using pluripotent stem cells to generate human stomach tissues in a petri dish that produce acid and digestive enzymes.

5 Jan 2017

Specific gene pathway appears to regulate growth, structure, and organization of cerebral cortex

One of the most significant ways in which the human brain is unique is the size and structure of the cerebral cortex. But what drives the growth of the human cortex, likely the foundation for our unique intellectual abilities?

30 Dec 2016

Ancient Japanese art inspires groundbreaking technique to create ‘artificial brains’

The ancient Japanese art of flower arranging was the inspiration for a groundbreaking technique to create tiny "artificial brains" that could be used to develop personalized cancer treatments.

6 Dec 2016

Nature article highlights use of QGel's designer matrices for intestinal and colorectal cancer organoid culture

Nature, the leading weekly international scientific journal, yesterday reported the first intestinal and colorectal cancer organoid culture in fully defined extra cellular matrices (ECM).

21 Nov 2016

New method to generate kidney organoids from patient cells can help study human kidney diseases

A new method to create kidney organoids from patient cells may provide insights into how kidney diseases arise and how they should be treated.

18 Nov 2016

Scientists reveal underlying mechanisms leading to microcephaly in NBS patients

Scientists from Jerusalem and Duesseldorf have succeeded in generating induced pluripotent stem cells from a rare disorder called Nijmegen breakage syndrome (NBS) and to push these cells to become early neurons, revealing the mechanisms leading to the neurological phenotype observed in these patients.

9 Sep 2016

Salk researchers develop new method to create unlimited numbers of precursor kidney cells

Salk Institute scientists have discovered the holy grail of endless youthfulness--at least when it comes to one type of human kidney precursor cell.

25 Aug 2016

Penn researchers uncover strategy to reverse effects of dyskeratosis congenita

Dyskeratosis congenita, or DC, is a rare, inherited disease for which there are limited treatment options and no cure.

18 Aug 2016

USC researchers discover two Zika proteins potentially responsible for microcephaly

USC researchers have tracked down two Zika proteins potentially responsible for thousands of microcephaly cases in Brazil and elsewhere — taking one small step toward preventing Zika-infected mothers from birthing babies with abnormally small heads.

11 Aug 2016

New findings on microcephaly may offer clues to explore how Zika virus disrupts brain development

Long before Zika virus made it a household word, the birth defect called microcephaly puzzled scientists and doctors -- even as it changed the lives of the babies born with it during the pre-Zika era.

8 Aug 2016

Scientists make a big leap on mini-brain research

Scientists in Singapore have made a big leap on research on the 'mini-brain'. These advanced mini versions of the human midbrain will help researchers develop treatments and conduct other studies into Parkinson's Disease and ageing-related brain diseases.

29 Jul 2016

Novel method uses lasers to carve paths inside biocompatible gels

Future medicine is bound to include extensive tissue-engineering technologies such as organs-on-chips and organoids - miniature organs grown from stem cells. But all this is predicated on a simple yet challenging task: controlling cellular behavior in three dimensions.

23 Jun 2016

Penn researchers help identify unique characteristics of reserve stem cells

Adult stem cells represent a sort of blank clay from which a myriad of different cell and tissue types are molded and as such are of critical importance to health, aging and disease.

16 Jun 2016

CGT, University of Aberdeen announce creation of new company to develop novel technology for diabetes treatment

The Cell and Gene Therapy Catapult and University of Aberdeen, UK, today announce the creation of Islexa, a new company developing a novel technology to produce laboratory grown islets, the organoids responsible for insulin production.

18 May 2016

Brazilian strain of Zika virus can cause severe birth defects

Researchers at University of California San Diego School of Medicine, with colleagues in Brazil and Senegal, have described the first "direct experimental proof" that the Brazilian strain of Zika virus can actually cause severe birth defects. The findings are published in the May 11 online issue of Nature.

12 May 2016

Study hints at new therapeutic approach to mitigate effects of prenatal Zika virus infection

The U.S. Centers for Disease Control and Prevention recently concluded that Zika virus infection in pregnant women can stunt neonatal brain development, leading to babies born with abnormally small heads, a condition known as microcephaly. Now, for the first time, researchers at University of California San Diego School of Medicine have determined one way Zika infection can damage developing brain cells.

9 May 2016

Brazilian researchers reveal harmful effects of Zika virus in human neural stem cells, neurospheres

Brazilian researchers from the D'Or Institute for Research and Education (IDOR) and Federal University of Rio de Janeiro (UFRJ) have demonstrated the harmful effects of ZIKA virus (ZIKV) in human neural stem cells, neurospheres and brain organoids.

12 Apr 2016

European researchers aim to spare people with type 1 diabetes from lifelong insulin therapy

More and more children in Europe and the USA are suffering from diabetes. A Group of European Researchers has now joined forces under the leadership of the Gothe University Frankfurt. They are searching for a new method in order to spare people with Diabetes type 1 from lifelong insulin therapy.

2 Apr 2016