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Study reveals needle biopsy hormone receptor testing for DCIS wastes millions

Study reveals needle biopsy hormone receptor testing for DCIS wastes millions

For patients with the most common type of noninvasive breast cancer, routine testing for estrogen and progesterone receptors in tissue taken at the first "needle" biopsy is both unnecessary and wasteful, according to results of a study led by Johns Hopkins pathologists. [More]
UTMB researchers unlock clues to understand signals that trigger labor and delivery process

UTMB researchers unlock clues to understand signals that trigger labor and delivery process

In a normal full-term pregnancy, signals from the mature organs of the fetus and the aging placental membranes and placenta prompt the uterus' muscular walls to begin the labor and delivery process. It's still unclear how these signals accomplish this goal or how they reach from the fetal side to the maternal side. [More]
UTA researchers find how changing estrogen levels make women more vulnerable to cocaine addiction

UTA researchers find how changing estrogen levels make women more vulnerable to cocaine addiction

Researchers at The University of Texas at Arlington are studying how fluctuating estrogen levels make females increasingly sensitive to the rewarding effects of cocaine and ultimately, vulnerable to cocaine addiction. [More]
AACC 2016: DRG International to exhibit Optimized Saliva ELISA Assays for measuring steroids

AACC 2016: DRG International to exhibit Optimized Saliva ELISA Assays for measuring steroids

DRG International, a leading international medical diagnostic company, will showcase the Newly Optimized DRG Saliva ELISA Assays at the 2016 AACC in Philadelphia, Pennsylvania from August 02-04. [More]
Postmenopausal estrogen supplement may not affect memory of healthy women

Postmenopausal estrogen supplement may not affect memory of healthy women

Contrary to popular belief, taking estrogen after menopause may not affect the memory and thinking abilities of healthy women no matter when the treatment is started. [More]
Researchers discover mechanism of gene silencing in hormone-dependent breast cancer cells

Researchers discover mechanism of gene silencing in hormone-dependent breast cancer cells

Sometimes, the silencing of a gene is as important as its activation. Nonetheless, up to now, most studies on hormone-mediated gene regulation have focused on researching the factors that influence the activation of certain genes. Little attention has been paid to gene silencing. [More]
Researchers tune into previously unknown cross talk between estrogen and progesterone receptors

Researchers tune into previously unknown cross talk between estrogen and progesterone receptors

One of the first clues pathologists look for in tissue from a newly diagnosed breast cancer patient is the estrogen receptor, a nuclear protein that converts hormonal messages in the bloodstream into instructions for the cell about how to behave [More]
Scientists find new way to slow growth of triple negative breast cancer

Scientists find new way to slow growth of triple negative breast cancer

CANCER RESEARCH UK scientists have found a new way to slow the growth of the most aggressive type of breast cancer, according to research published in the journal Oncogene today (Monday). [More]
Luteal phase of menstrual cycle may help thwart smoking behavior in women

Luteal phase of menstrual cycle may help thwart smoking behavior in women

Women who want to quit smoking may have better success by carefully timing their quit date with optimal days within their menstrual cycle, according to a new study from researchers at the Perelman School of Medicine at the University of Pennsylvania. [More]
Researchers spot molecular key that breast cancer cells use to invade bone marrow

Researchers spot molecular key that breast cancer cells use to invade bone marrow

Scientists at the Duke Cancer Institute have identified a molecular key that breast cancer cells use to invade bone marrow in mice, where they may be protected from chemotherapy or hormonal therapies that could otherwise eradicate them. [More]
Vitamin D and androgen receptor-targeted therapy may help treat TNBC

Vitamin D and androgen receptor-targeted therapy may help treat TNBC

A recent study by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine revealed that triple-negative breast cancer (TNBC), which has generally been unresponsive to hormone receptor-targeted treatments, can indeed be treated using vitamin D and androgen receptor-targeted therapy. [More]
DECT trial shows combination of epirubicin and trastuzumab improves outcomes in breast cancer patients

DECT trial shows combination of epirubicin and trastuzumab improves outcomes in breast cancer patients

The study entitled "A phase II neoadjuvant sequential regimen of docetaxel followed by high-dose epirubicin in combination with cyclophosphamide administered concurrently with trastuzumab. [More]
EAD therapy can shrink size of triple-negative breast cancer tumors in mice

EAD therapy can shrink size of triple-negative breast cancer tumors in mice

In a new study using mice and lab-grown human cells, a scientific team led by Johns Hopkins Kimmel Cancer Center researchers show how a triple-drug cocktail can shrink triple-negative breast cancers by killing off cancer cells and halting new tumor growth. [More]
Researchers identify low MCJ expression as marker of poor response to chemotherapy

Researchers identify low MCJ expression as marker of poor response to chemotherapy

Chemotherapy is a key part of the standard treatment regimen for triple-negative breast cancer patients whose cancer lacks expression of estrogen and progesterone receptors and the human epidermal growth factor receptor 2 (HER2). [More]
UW-Madison researchers develop quick, saliva-based test for measuring fertility hormone levels

UW-Madison researchers develop quick, saliva-based test for measuring fertility hormone levels

Doubts about their ability to become pregnant affect as many as 25 percent of American women, and solving that problem is the basic business plan for BluDiagnostics. Although the startup company was born in the University of Wisconsin-Madison Biochemistry Department, co-founder Katie Brenner says the idea came directly from her own difficulty with conception. [More]
New class of cancer-driver gene may serve as unique therapeutic targets, biomarkers in TNBC

New class of cancer-driver gene may serve as unique therapeutic targets, biomarkers in TNBC

The discovery of long non-coding RNA (lncRNA) has dramatically changed the understanding of the biology of diseases such as cancer. The human genome contains about 20,000 protein-coding genes - less than 2 percent of the total - but 70 percent of the genome is made into non-gene-encoding RNA. [More]
Derivatives of female sex hormones can influence natural melanin production, study suggests

Derivatives of female sex hormones can influence natural melanin production, study suggests

When skin cells responsible for pigmentation are exposed to estrogen or progesterone, the cells respond by adjusting their melanin production, resulting in either skin darkening or lightening. Although pregnant women often experience alterations in skin pigmentation, the reason for the changes has long puzzled physicians. [More]
Low-oxygen conditions spur growth of breast cancer stem cells

Low-oxygen conditions spur growth of breast cancer stem cells

Working with human breast cancer cells and mice, scientists at The Johns Hopkins University say new experiments explain how certain cancer stem cells thrive in low oxygen conditions. Proliferation of such cells, which tend to resist chemotherapy and help tumors spread, are considered a major roadblock to successful cancer treatment. [More]
UC Berkeley biologists discover potential target for unisex contraceptives

UC Berkeley biologists discover potential target for unisex contraceptives

UC Berkeley biologists have discovered the switch that triggers the power kick sperm use to penetrate and fertilize a human egg, uncovering a possible source of male infertility but also a potential target for contraceptives that work in both men and women. [More]
Delivering microRNAs in cancer treatment: an interview with Dr Conde and Prof Artzi

Delivering microRNAs in cancer treatment: an interview with Dr Conde and Prof Artzi

microRNAs (miRs) are small endogenous noncoding RNA molecules (20–23 nucleotides) derived from imperfectly paired hairpin RNA structures naturally encoded in the genome that act specifically as triggering molecules to control translational repression or mRNA degradation. [More]
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