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New less invasive method could detect bacterial infection in young febrile infants

New less invasive method could detect bacterial infection in young febrile infants

Physicians from Children's Hospital of Michigan, Wayne State University, UC Davis Medical Center and Nationwide Children's Hospital, in collaboration with 19 other pediatric emergency departments around the country, have established a "proof of principle" for measuring patterns of ribonucleic acid (RNA) expression in the bloodstream that can enable clinicians to distinguish bacterial infections from other causes of fever in infants up to two months old. [More]
NUS study reveals RNA editing events play vital role in gastric cancer development

NUS study reveals RNA editing events play vital role in gastric cancer development

A team of researchers from the Cancer Science Institute of Singapore at the National University of Singapore has found that changes in ribonucleic acid (RNA) sequences play a major role in the development of gastric cancer. [More]
New blood test helps identify bacterial infection in infants with fever

New blood test helps identify bacterial infection in infants with fever

A blood test used to measure patterns of ribonucleic acid (RNA) expression can help determine if fever in infants under 2 months old is caused by bacterial or viral infection, according to a preliminary study recently published in the Journal of the American Medical Association. [More]
Scientists find way to boost efficiency with which CRISPR-Cas9 cuts and disables genes

Scientists find way to boost efficiency with which CRISPR-Cas9 cuts and disables genes

CRISPR-Cas9 is the go-to technique for knocking out genes in human cell lines to discover what the genes do, but the efficiency with which it disables genes can vary immensely. [More]
Study shows miR-19 helps new neurons in the adult brain stay on track

Study shows miR-19 helps new neurons in the adult brain stay on track

A small stretch of ribonucleic acid called microRNA could make the difference between a healthy adult brain and one that's prone to disorders including schizophrenia. [More]
New research pinpoints specific lncRNA that regulates neural development

New research pinpoints specific lncRNA that regulates neural development

Compared to other mammals, humans have the largest cerebral cortex. A sheet of brain cells that folds in on itself multiple times in order to fit inside the skull, the cortex is the seat of higher functions. It is what enables us to process everything we see and hear and think. [More]
RNA molecular dynamics research provides key insights into new treatments for retroviral diseases

RNA molecular dynamics research provides key insights into new treatments for retroviral diseases

New molecular dynamics research into how RNA folds into hairpin-shaped structures called tetraloops could provide important insights into new treatments for retroviral diseases. [More]
New optimised PCR tests for reliable diagnosis of Zika virus

New optimised PCR tests for reliable diagnosis of Zika virus

DZIF scientists from the University of Bonn have shown that not all conventional Zika virus molecular diagnostic tests for are sufficiently reliable. They developed optimised assays and a control for quantifying viruses in blood and urine. [More]
Researchers identify gene crucial to development of coeliac disease

Researchers identify gene crucial to development of coeliac disease

Coeliac disease is a chronic, immunological disease that is manifested as intolerance to gluten proteins present in wheat, rye and barley. This intolerance leads to an inflammatory reaction in the small intestine that hampers the absorption of nutrients. The only treatment is a strict, life-long, gluten-free diet. [More]
New project aims to prevent complications from drug usage

New project aims to prevent complications from drug usage

If a patient is ill and takes drugs for that illness, these drugs often lead to further illnesses and complications. This affects millions of people throughout the world. [More]
TGen scientists highlight advantages of using RNA-sequencing in precision medicine

TGen scientists highlight advantages of using RNA-sequencing in precision medicine

Uncovering the genetic makeup of patients using DNA sequencing has in recent years provided physicians and their patients with a greater understanding of how best to diagnose and treat the diseases that plague humanity. This is the essence of precision medicine. [More]
Study sheds light on role of RNA editing in cancer

Study sheds light on role of RNA editing in cancer

A new study provides insight on the potential role played by RNA (ribonucleic acid) editing in cancer. The findings, which appear online in the journal Scientific Reports, may further our understanding of an emerging mechanism implicated in tumor initiation and progression, and may thus lead to the development of better treatment options in the future. [More]
Newly identified RNA biomarkers open door for simple, accurate non-invasive test for prostate cancer

Newly identified RNA biomarkers open door for simple, accurate non-invasive test for prostate cancer

A study on non-coding RNA (Ribonucleic Acid) from prostate cancer patients has identified a series of new prostate cancer markers which can be found in urine. Combining these RNA markers into a single test potentially opens the door for simple, accurate non-invasive testing for prostate cancer. [More]
Research findings may provide highly effective therapeutic strategy for treatment of Alzheimer's, AMD

Research findings may provide highly effective therapeutic strategy for treatment of Alzheimer's, AMD

For the first time, researchers at LSU Health New Orleans have shown that a protein critical to the body's ability to remove waste products from the brain and retina is diminished in age-related macular degeneration, after first making the discovery in an Alzheimer's disease brain. The research team, led by Walter Lukiw, PhD, Professor of Neurology, Neuroscience and Ophthalmology at LSU Health New Orleans Neuroscience Center, also discovered a key reason, identifying a new treatment target. [More]
Major breakthrough opens door to better understanding of molecular mechanisms of pancreatic cancer

Major breakthrough opens door to better understanding of molecular mechanisms of pancreatic cancer

Pancreatic cancer carries a very bleak prognosis for patients. However, a recent breakthrough by two research teams, including one at the Hôpital Maisonneuve-Rosemont (CIUSSS-EST, Montreal) and University of Montreal, has opened the door to a better understanding of the molecular mechanisms that cause this cancer to develop. [More]
Scientists propose use of mathematical models to find better treatment for bladder cancer

Scientists propose use of mathematical models to find better treatment for bladder cancer

MIPT scientists together with their colleagues from St. Petersburg and Israel have analyzed more than 500 previously published scientific articles and proposed their own approach to the choice of methods used for the treatment of one of the most common cancers. [More]
New gene editing technique could hinder retinal degeneration in rats with inherited blindness

New gene editing technique could hinder retinal degeneration in rats with inherited blindness

A new technique that has the potential to treat inherited diseases by removing genetic defects has been shown for the first time to hinder retinal degeneration in rats with a type of inherited blindness, according to a Cedars-Sinai study. [More]
DNA damage may lead to mutation and changes in cell

DNA damage may lead to mutation and changes in cell

A team of researchers from Colorado State University has been studying DNA damage in living cells to learn more about how genetic abnormalities arise. It has long been known that DNA molecules in every cell get constantly damaged by things from the outside environment, like sunlight, cigarette smoke and radiation. However, more recently researchers have discovered that sources from within the cell itself can sometimes be even more damaging. [More]
Study may hold new revelations about how stress during pregnancy affects mothers and offspring

Study may hold new revelations about how stress during pregnancy affects mothers and offspring

The sequencing of the first genome involving a cockroach species may one day serve as a model system comparable to how research on mice can apply to humans. In this case, the model could hold new revelations about how stress during pregnancy could affect both the mother and her offspring. [More]
Roche announces availability of cobas HBVassay for use on cobas 4800 System

Roche announces availability of cobas HBVassay for use on cobas 4800 System

Roche announced today the commercial availability of the cobas HBVassay for use on the cobas 4800 System in countries accepting the CE mark. This new molecular diagnostic assay expands the available virology menu on the cobas 4800 System, improving system efficiency and providing testing flexibility that allows physicians to assess a patient's response to antiviral therapy. [More]
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