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Glucokinase activators induce hepatic lipid accumulation in mice with high-fat diet

The researchers demonstrated that glucokinase activation was effective in lowering blood glucose in mice with high-fat diet-induced obesity, while it potentially raised the risk of increasing hepatic lipid accumulation that triggered the PERK-UPR pathway.

11 Aug 2023

New mechanism discovered for brain repair after ischemic stroke

Patients often experience functional decline after an ischemic stroke, especially due to the brain's resistance to regenerate after damage.

10 Aug 2023

How conversion between different types of cell death contributes to disease

Researchers elucidate the role of cell death in the pathogenesis of different diseases.

10 Aug 2023

Mitochondrial protein structure activates cell's integrated stress response

Often referred to as the "powerhouses of the cell," mitochondria are well known for their role as energy suppliers, but these organelles are also critical for maintaining our overall health.

8 Aug 2023

Identification of plasma proteins associated with ovarian cancer risk

Researchers performed proteomic Mendelian randomization as well as co-localization analyses to identify drug targets for ovarian cancer.

8 Aug 2023

Researchers discover how aging can lead to chronic metabolic disorders

Korean researchers have unveiled a novel signaling pathway that fosters aging-related chronic metabolic disorders.

3 Aug 2023

Study reveals mechanism through which insulin-like growth factors facilitate brain plasticity

Research from the Max Planck Florida Institute for Neuroscience has identified a mechanism through which insulin-like growth factors facilitate brain plasticity.

3 Aug 2023

Research sheds light on the causes of endometriosis-related pelvic pain

Pelvic pain in women with endometriosis is attributed to neuroinflammation. Researchers investigated biochemical mediators of endometriosis-associated pelvic pain to provide a foundation to identify new drugs to improve symptoms and quality of life.

3 Aug 2023

The roles and plausible mechanisms of pyroptosis in renal inflammation and fibrosis

Researchers summarize available data on pyroptosis in the context of renal fibrosis, as well as its prevention and treatment.

1 Aug 2023

What is the relationship between intestinal stem cells and the gut microbiota in regenerative medicine?

Researchers explored the relationship between intestinal stem cells (ISCs) and the gut microbiota and its role in maintaining intestinal health.

1 Aug 2023

Two new compounds can block cancer cell’s escape route

Cancer cells are capable of escaping chemotherapy and radiotherapy by activating a signaling pathway that prevents them from dying.

27 Jul 2023

The role of diet in the management of retinal vein occlusion

Researchers investigate the potential impact of dietary habits on retinal vein occlusion.

27 Jul 2023

Primary cilia play a critical role in growth plate regeneration

Growth plates (GP), situated at the ends of long bones in children, supply chondrocytes necessary for bone growth.

25 Jul 2023

Meclofenamate shows promise in treating abnormal respiratory mucus

Our respiratory system is lined with a thin fluid layer called mucus on the inside. The mucus protects us from inhaling harmful and unwanted airborne agents from germs to pollutants; it achieves this feat due to its unique gel-like texture imparted by proteins called mucins.

25 Jul 2023