siRNA News and Research

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Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA molecules, 20-25 nucleotides in length, that play a variety of roles in biology. Most notably, siRNA is involved in the RNA interference (RNAi) pathway, where it interferes with the expression of a specific gene. In addition to their role in the RNAi pathway, siRNAs also act in RNAi-related pathways, e.g., as an antiviral mechanism or in shaping the chromatin structure of a genome; the complexity of these pathways is only now being elucidated.

Sylentis presents clinical study results of new treatment for dry eye syndrome

Sylentis, Pharmaceutical Company belonging to the PharmaMar Group, has presented results from the clinical studies carried out with tivanisiran for the treatment of dry eye syndrome and that has enabled the start-up of the Phase III "Helix" clinical trial.

3 May 2018

Novel cell-based screening array reduces time and cost of drug discovery

Porvair Sciences has collaborated with Persomics Inc. to develop and supply ANSI/SLAS format Arrays as an OEM product for their ImagineArray™ platform.

From Porvair Sciences Limited 28 Apr 2018

Newly designed three-part molecule shows promise to treat breast cancers

A newly designed three-part molecule could be the one answer patients with a certain form of breast cancer are looking for, scientists report.

22 Mar 2018

New study shows advantages of DNA barcoding technique for identifying nanoparticles

The first direct comparison of in vitro and in vivo screening techniques for identifying nanoparticles that may be used to transport therapeutic molecules into cells shows that testing in lab dishes isn't much help in predicting which nanoparticles will successfully enter the cells of living animals.

5 Mar 2018

New modular platform offers robust biological approach that targets endless number of diseases

The biological complexity of cancer and other diseases demands a more formidable arsenal of therapies than currently available. Most therapeutic approaches ignore the dynamic molecular network of genes, targeting instead only very few selected disease-related genes.

1 Feb 2018

Novel nanomedicine prolongs survival of pancreatic tumor-bearing mice

A new Tel Aviv University study pinpoints the inverse correlation between a known oncogene -- a gene that promotes the development of cancer -- and the expression of an oncosuppressor microRNA as the reason for extended pancreatic cancer survival.

2 Jan 2018

Researchers use RNA nanotechnology to program exosomes for delivering effective cancer therapies

A new study shows that attaching antibody-like RNA nanoparticles to microvesicles can deliver effective RNA therapeutics such as small interfering RNA specifically to cancer cells.

13 Dec 2017

Retinal diseases could be treated by ophthalmic drops instead of intraocular injections

The Spanish firm Sylentis has developed a compound to treat diseases of the retina, such as age-related macular degeneration and diabetic retinopathy, which will be administered by ophthalmic drops instead of intraocular injections.

12 Dec 2017

Texas Biomedical Research Institute tests promising new treatment for HBV infection

Research at the Southwest National Primate Research Center on the campus of Texas Biomedical Research Institute helped advance a new treatment now in human trials for chronic hepatitis B virus (HBV) infection.

7 Nov 2017

Researchers win $1.4 million federal grant to study new treatment approaches for intestinal inflammation

Researchers in Georgia State University's Institute for Biomedical Sciences have received a four-year, $1.4 million federal grant to study novel therapeutic approaches for the treatment of intestinal inflammation.

7 Aug 2017

Study demonstrates potential nanoparticle-based therapeutic strategy for deadly brain tumors

Early phase Northwestern Medicine research has demonstrated a potential new therapeutic strategy for treating deadly glioblastoma brain tumors.

13 Jul 2017

Genetic manipulation of exosomes may offer new therapeutic approach to treating pancreatic cancer

Genetic manipulation of exosomes, virus-sized particles released by all cells, may offer a new therapeutic approach to treating pancreatic cancer, according to a study at The University of Texas MD Anderson Cancer Center.

8 Jun 2017

Leti's New Deal project could revolutionize IBD therapies for great benefit of patients in the European Union

Leti, a technology research institute of CEA Tech, today announced a European Union project to develop a nanotherapy targeting the molecules involved in inflammatory bowel diseases (IBD), such as Crohn’s disease and ulcerative colitis.

12 May 2017

Study reveals potential therapeutic target for kidney fibrosis

When the kidneys - vital organs for filtering the body's entire blood supply - become injured, it can set in motion an unfortunate chain of events that leads to a decline in health.

20 Apr 2017

Single dose of siRNA molecule offers protection against heart attack and stroke in high-risk patients

Even a single dose of a specific ribonucleic acid molecule, known as a small interfering RNA (siRNA), offers patients at high risk of cardiovascular disease long-lasting protection against high LDL cholesterol - one of the main risk factors for heart attack and stroke.

30 Mar 2017

Scientists reveal novel drug delivery approach to fight swine flu at gene level

Scientists from Tomsk Polytechnic University together with their colleagues from St. Petersburg and London have elaborated a new approach to deliver anti-viral RNAi to target cells against H1N1 influenza virus infection.

28 Mar 2017

Scientists identify genetic clues to chronic kidney disease

Using international genomic studies backed by proof-of-concept cell experiments, researchers have identified two genes that contribute to the chronic kidney disease glomerulonephritis.

16 Mar 2017

Precision NanoSystems launches NanoAssemblr Scale-Up system to support production of novel medicines

Precision NanoSystems has launched the NanoAssemblr™ Scale-Up system to support the clinical development of nanomedicines.

From Precision NanoSystems Inc. 9 Mar 2017

Using Spherical Nucleic Acids to Track and Treat Disease

Spherical nucleic acids are structures that are made by taking a nanoparticle template and using chemistry to arrange short strands of DNA or RNA on the surface of those particles. The spherical core of the nanoparticle creates a spherical arrangement of DNA or RNA, similar to tiny little balls of nucleic acids.

From Pittcon 1 Mar 2017

Glowing mice could mark major step forward for new gene therapy

Timothy Blake, a postdoctoral fellow in the Waymouth lab, was hard at work on a fantastical interdisciplinary experiment. He and his fellow researchers were refining compounds that would carry instructions for assembling the protein that makes fireflies light up and deliver them into the cells of an anesthetized mouse. If their technique worked, the mouse would glow in the dark.

16 Feb 2017