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Clinical trial tests creatine monohydrate and exercise to preserve muscle mass in prostate cancer patients

The National Cancer Institute awarded investigators at Huntsman Cancer Institute a grant totaling more than $3 million to conduct a clinical trial to see if combining creatine monohydrate supplementation and resistance exercise training helps preserve muscle in people who have metastatic prostate cancer.

11 Oct 2023

Saline injection treatment for calcific tendinopathy provides no meaningful benefit over placebo

A saline injection treatment widely used for calcific tendinopathy - a common, painful condition caused by a build-up of calcium in the rotator cuff tendons of the shoulder - provides no meaningful benefit over placebo, concludes a trial published by The BMJ today.

11 Oct 2023

A novel drug reduces the monthly frequency of seizure in adults with focal epilepsy

The effect of a novel Kv7.2/Kv7.3 potassium channel opener XEN1101 in reducing monthly seizure frequency in adults.

11 Oct 2023

HKU-developed antibiotic drug to enter clinical trials in Mainland China

A new antibiotic drug developed by a research team led by Professor Li Xuechen from the Department of Chemistry at The University of Hong Kong (HKU) has recently gained approval from the authorities to undergo clinical trials in the Mainland.

10 Oct 2023

Can a low-carb, anti-inflammatory diet be the answer to long COVID woes?

Keck Medicine of USC is conducting a clinical trial to determine if a low-carbohydrate, anti-inflammatory diet combined with a medical food raising blood ketone levels can alleviate symptoms of long COVID. The study, based on the theory that prolonged inflammation post-COVID infection causes the syndrome, aims to examine the diet's efficacy in reducing inflammation and improving patients' health.

10 Oct 2023

Nasal mupirocin found to be highly effective at preventing Staphylococcus aureus infections in critically ill patients

A large multi-state study by the Centers for Disease Control and Prevention, the Harvard Pilgrim Health Care Institute, HCA Healthcare, and the University of California, Irvine has found that a nasal antibiotic ointment, mupirocin, which is currently used daily for intensive care unit (ICU) patients in only one-third of U.S. hospitals, is highly effective at preventing Staphylococcus aureus infections in critically ill patients, outperforming an antiseptic solution.

10 Oct 2023

New drug shows promise for epilepsy patients with resistant seizures

In cases where standard therapies fail, a medication called XEN1101 reduces seizure frequency by more than 50% in some patients and sometimes eliminates them altogether, a new study shows.

9 Oct 2023

Solriamfetol may be an effective alternative for managing ADHD in adults, trial shows

Although several medications are approved to treat attention-deficit/hyperactivity disorder (ADHD), some individuals experience limited benefits from the drugs or develop side effects from their use.

9 Oct 2023

Next-gen intranasal vaccine takes on measles, mumps, and multiple COVID-19 variants in one shot

Researchers developed an intranasal trivalent measles-mumps-SARS-CoV-2 vaccine that provides robust protection against multiple coronavirus variants. Leveraging the established measles-mumps-rubella platform, this vaccine demonstrates broad and adaptable immune responses, especially against Delta and Omicron variants.

8 Oct 2023

Novavax vaccine shows resilient defense against symptomatic COVID-19 despite Omicron challenge

Recent study assesses NVX-CoV2373 vaccine's effectiveness against Omicron variant. Findings show decreased efficacy over four months, but stable protection against symptomatic COVID-19.

8 Oct 2023

Inhaled nitric oxide shows promise as treatment for COVID-19 respiratory failure

Inhaled nitric oxide gas widens blood vessels in the lungs and is used to treat severe cardio-pulmonary conditions in newborns and adults.

6 Oct 2023

Breakthrough study shows immunotherapy can help prevent bladder cancer recurrence

The Alliance for Clinical Trials in Oncology today announced that the Alliance Data and Safety Monitoring Board (DSMB) determined that the phase III AMBASSADOR (A031501) trial met one of its dual primary endpoints of disease-free survival (DFS) for the adjuvant treatment of patients with localized muscle-invasive urothelial carcinoma (MIUC) and locally advanced urothelial carcinoma.

5 Oct 2023

Esketamine outperforms one of the standard drugs for treatment-resistant major depression

A major clinical trial shows that the drug, esketamine, one of the two main forms of ketamine, outperforms one of the standard treatments for treatment-resistant major depression.

4 Oct 2023

New meningitis vaccine safe and effective for infants in Africa

University of Maryland School of Medicine (UMSOM) researchers, as part of the Infectious Diseases Clinical Research Consortium (IDCRC), provided an interim analysis showing that the pentavalent (NmCV-5) meningitis vaccine is safe for use in 9-month-old infants in the meningitis belt of sub-Saharan Africa.

3 Oct 2023

Survey: Racial and ethnic minorities less likely to participate in clinical trials

A survey conducted in one cancer center's catchment area found that while a majority of respondents would be willing to participate in a clinical trial, members of racial and ethnic minority groups were significantly less likely to participate than non-Hispanic whites, according to results presented at the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held September 29-October 2, 2023.

29 Sep 2023

NCI-sponsored cancer clinical trials become more representative of broader patient population

Compared to the year 2000, a greater proportion of NCI-sponsored early-phase clinical trial participants in 2022 were older, from minority racial/ethnic groups, and lived in historically underrepresented regions of the U.S., according to a study presented at the 16th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held September 29-October 2, 2023.

29 Sep 2023

Extending FDA-approved cancer drug indications requires high patient numbers, study finds

Number of patient participants needed for secondary approval of a new cancer drug.

29 Sep 2023

Intranasal vaccine shows promise against COVID variants in hamsters

Intranasal mRNA-LNP vaccines show promise in Syrian golden hamsters, effectively reducing SARS-CoV-2 viral loads and lung pathology. The study suggests potential efficacy against new variants, setting the stage for future research in human applications.

25 Sep 2023

Clinical study launched to test the benefits of immune modulation for hospitalized COVID-19 patients

A clinical trial has launched to test whether early intensive immune modulation for hospitalized COVID-19 patients with relatively mild illness is beneficial.

22 Sep 2023

Inhaled fluticasone furoate falls flat in speeding up COVID-19 recovery, says ACTIV-6 trial

The ACTIV-6 trial investigated the effectiveness of inhaled fluticasone furoate on mild-to-moderate COVID-19 cases and found it did not accelerate recovery or prevent clinical progression compared to a placebo. Interestingly, vaccinated participants showed slightly faster recovery when treated with the drug, while unvaccinated participants did not.

21 Sep 2023

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Drug Trial News

Clinical trial tests creatine monohydrate and exercise to preserve muscle mass in prostate cancer patients

Saline injection treatment for calcific tendinopathy provides no meaningful benefit over placebo

A novel drug reduces the monthly frequency of seizure in adults with focal epilepsy

HKU-developed antibiotic drug to enter clinical trials in Mainland China

Can a low-carb, anti-inflammatory diet be the answer to long COVID woes?

Nasal mupirocin found to be highly effective at preventing Staphylococcus aureus infections in critically ill patients

New drug shows promise for epilepsy patients with resistant seizures

Solriamfetol may be an effective alternative for managing ADHD in adults, trial shows

Next-gen intranasal vaccine takes on measles, mumps, and multiple COVID-19 variants in one shot

Novavax vaccine shows resilient defense against symptomatic COVID-19 despite Omicron challenge

Inhaled nitric oxide shows promise as treatment for COVID-19 respiratory failure

Breakthrough study shows immunotherapy can help prevent bladder cancer recurrence

Esketamine outperforms one of the standard drugs for treatment-resistant major depression

New meningitis vaccine safe and effective for infants in Africa

Survey: Racial and ethnic minorities less likely to participate in clinical trials

NCI-sponsored cancer clinical trials become more representative of broader patient population

Extending FDA-approved cancer drug indications requires high patient numbers, study finds

Intranasal vaccine shows promise against COVID variants in hamsters

Clinical study launched to test the benefits of immune modulation for hospitalized COVID-19 patients

Inhaled fluticasone furoate falls flat in speeding up COVID-19 recovery, says ACTIV-6 trial

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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