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Scientists elucidate why acute leukemias with same genetic abnormality vary in aggressiveness

Scientists elucidate why acute leukemias with same genetic abnormality vary in aggressiveness

Scientists at the Friedrich Miescher Institute for Biomedical Research and the University of Basel have discovered why acute leukemias with the same genetic abnormality vary in their aggressiveness based on their cellular origin. [More]
Photodynamic therapy effective in treating porphyrias but can be severely painful, cause inflammation

Photodynamic therapy effective in treating porphyrias but can be severely painful, cause inflammation

Severe paleness and photosensitivity are two symptoms of a rare group of hereditary diseases that affect haem, a substance in the blood. While these metabolic disorders - known as the porphyrias - are extremely rare, a similar effect is often deliberately triggered by dermatologists in localised areas during the treatment of pre-cancerous skin lesions and skin cancers. [More]
CD Laboratory at MedUni Vienna explores new therapeutic approaches to enhance peritoneal dialysis

CD Laboratory at MedUni Vienna explores new therapeutic approaches to enhance peritoneal dialysis

One of the main functions of the kidneys is to filter metabolic products out of the blood. If the kidneys are no longer able to do this, the blood has to be artificially purified and drained of excess fluid. [More]
Depression reduces COPD maintenance medication adherence in older adults

Depression reduces COPD maintenance medication adherence in older adults

A recent study in the Annals of the American Thoracic Society found that in a nationally representative sample of Medicare beneficiaries who were newly diagnosed with COPD, adherence to maintenance medications decreased with new episodes of depression. [More]
Researchers identify new potential target for pancreatic cancer treatment

Researchers identify new potential target for pancreatic cancer treatment

Using an innovative approach to identify a cancer's genetic vulnerabilities by more swiftly analyzing human tumors transplanted into mice, researchers have identified a new potential target for pancreatic cancer treatment, published online in Cell Reports. [More]
New insights into cancer cell signaling could help prevent metastases

New insights into cancer cell signaling could help prevent metastases

Research published yesterday in Nature Communications has revealed a previously unknown mechanism by which metastasising cancer cells survive when they break away from the primary tumour. It is hoped that the discovery could help with the development of novel cancer treatments that prevent metastasis. [More]
Researchers reveal integrins could be key to survival mechanism in cancer cells

Researchers reveal integrins could be key to survival mechanism in cancer cells

Cancer cells appear to depend on an unusual survival mechanism to spread around the body, according to an early study led by Queen Mary University of London. The discovery could help with future development of novel treatments to prevent metastasis and secondary tumours. [More]
Gamma-ray irradiation improves safety of stem cell transplantation in Parkinson’s disease patients

Gamma-ray irradiation improves safety of stem cell transplantation in Parkinson’s disease patients

Replacing dopamine-producing cells in the brain represents a promising therapeutic approach in Parkinson's disease, and a new study shows how post-transplantation gamma-ray irradiation can reduce the risk of tumor formation. [More]
Broccoli sprout extract may help prevent cancer recurrence in head and neck cancer survivors

Broccoli sprout extract may help prevent cancer recurrence in head and neck cancer survivors

Potent doses of broccoli sprout extract activate a "detoxification" gene and may help prevent cancer recurrence in survivors of head and neck cancer, according to a trial by the University of Pittsburgh Cancer Institute, partner with UPMC CancerCenter, confirming preliminary results presented last year at the American Association for Cancer Research Annual Meeting. [More]
Centrally assisted collaborative telecare model improves PTSD/depression symptoms in soldiers

Centrally assisted collaborative telecare model improves PTSD/depression symptoms in soldiers

Military members who visited a primary care clinic while suffering from post-traumatic stress disorder and depression reported fewer symptoms and better mental health functioning a year after enrolling in a treatment program that included specially trained care managers and telephone therapy options, according to a new study conducted by RTI International, RAND and the Department of Defense Deployment Health Clinical Center. [More]
Yale-led study shows how EGFR silences tumor suppressor genes

Yale-led study shows how EGFR silences tumor suppressor genes

A Yale-led study describes how a known cancer gene, EGFR, silences genes that typically suppress tumors. The finding, published in Cell Reports, may lead to the development of more effective, individualized treatment for patients with lung cancer and other cancer types. [More]
Mice study shows influence of dad's obesity on daughter’s body weight and breast cancer risk

Mice study shows influence of dad's obesity on daughter’s body weight and breast cancer risk

Obese male mice and normal weight female mice produce female pups that are overweight at birth through childhood, and have delayed development of their breast tissue as well as increased rates of breast cancer. [More]
Diabetes, kidney disease may play role in increasing adverse cardiovascular outcomes among African Americans

Diabetes, kidney disease may play role in increasing adverse cardiovascular outcomes among African Americans

New research indicates that diabetes and kidney disease may increase African Americans' risk of stroke and coronary heart disease, as well as their risk of dying from cardiovascular causes. [More]
Researchers develop new formulations for topical treatments of oral mucosal conditions

Researchers develop new formulations for topical treatments of oral mucosal conditions

On June 24, 2016, at the 94th General Session & Exhibition of the International Association for Dental Research, researcher W. Peter Holbrook, University of Iceland, will present a study titled "Development of Drugs for Local Treatment of Oral Conditions." The IADR General Session is being held in conjunction with the 3rd Meeting of the IADR Asia Pacific Region and the 35th Annual Meeting of the IADR Korean Division. [More]
Regular park visits for 30 minutes may help prevent high blood pressure and mental health problems

Regular park visits for 30 minutes may help prevent high blood pressure and mental health problems

People who visit parks for 30 minutes or more each week are much less likely to have high blood pressure or poor mental health than those who don't, according to new research by Australian and UK environmental scientists. [More]
Overweight and obesity increase risk for periodontitis

Overweight and obesity increase risk for periodontitis

Today at the 94th General Session & Exhibition of the International Association for Dental Research, researcher Marco Peres, The University of Adelaide, South Australia, will present a study titled "Overweight and Obesity Impact on Periodontitis: A Brazilian Birth Cohort." [More]
Scientists discover how faulty genetic instructions contribute to development of AML

Scientists discover how faulty genetic instructions contribute to development of AML

Scientists have previously identified a series of genetic errors that commonly occur inside cancerous blood cells, but it hasn't been clear exactly how those genetic malfunctions create immature blood cells that overpopulate, crowd out healthy cells and spread in patients with acute myeloid leukemia or AML. [More]
Researchers use sensitive technique to reveal high levels of genetic heterogeneity in schizophrenia

Researchers use sensitive technique to reveal high levels of genetic heterogeneity in schizophrenia

International researchers centered at Nagoya University use a highly sensitive technique to identify significantly more DNA sequence repeats in patients with schizophrenia than in control individuals, and outline a possible link between genome instability and disease. [More]
University of Miami researchers awarded new contracts to detect genetic factors linked to Alzheimer's disease risk

University of Miami researchers awarded new contracts to detect genetic factors linked to Alzheimer's disease risk

Alzheimer's disease is the leading cause of dementia in the elderly and occurs in all ethnic and racial groups. It affects more than 5 million people age 65 and older in the United States alone and there is currently no effective treatment or cure. [More]
Taking ipilimumab, nivolumab drugs may increase risk of developing rheumatologic diseases

Taking ipilimumab, nivolumab drugs may increase risk of developing rheumatologic diseases

Case reports on 13 cancer patients suggest that a small number of cancer patients taking the immunotherapy drugs ipilimumab and nivolumab may be at some higher-than-normal risk of developing autoimmune joint and tissue diseases, including inflammatory arthritis, according to a preliminary study by Johns Hopkins Medicine researchers. [More]
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