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PHD1 inhibition may have therapeutic potential for colorectal cancer

Scientists at VIB and KU Leuven have shown that blocking the PHD1 oxygen sensor hinders the activation of p53, a transcription factor that aids colorectal cancer (CRC) cells in repairing themselves and thus resisting chemotherapy. Chemotherapy resistance remains a major clinical issue in the treatment of CRC. These findings indicate that PHD1 inhibition may have valuable therapeutic potential. The study was published in the leading medical journal EMBO Molecular Medicine, which features molecular biology-driven research.

19 Aug 2015

Further understanding of genetic influence in ALS to be explored in new partnership

Biogen, the ALS Association and Columbia University Medical Center (CUMC) today announced a new collaboration to better understand the differences and commonalities in the ALS disease process and how genes influence the clinical features of the disease.

19 Aug 2015

Scientists reveal link between smaller hippocampal brain volume and marijuana use

How scientists study the effects of marijuana on the brain is changing. Until recently marijuana research largely excluded tobacco users from its participant pool, but scientists at the Center for BrainHealth at The University of Texas at Dallas have found reason to abandon this practice, uncovering significant differences in the brains of individuals who use both tobacco and marijuana and the brains of those who only use marijuana.

19 Aug 2015

UC Davis researchers set out to identify biomarkers for early diagnosis of lung cancer

Despite decades of warnings about smoking, lung cancer is still the second-most common cancer and the leading cause of death from cancer in the U.S. Patients are often diagnosed only when their disease is already at an advanced stage and hard to treat. Researchers at the West Coast Metabolomics Center at UC Davis are trying to change that, by identifying biomarkers that could be the basis of early tests for lung cancer.

19 Aug 2015

Discovery allows study of naturally occurring forms of HCV in the lab

Worldwide, 185 million people have chronic hepatitis C. Since the late 1980s, when scientists discovered the virus that causes the infection, they have struggled to find ways to grow it in human cells in the lab -- an essential part of learning how the virus works and developing new effective treatments.

19 Aug 2015

IDT webinar explores effective RNAi and antisense oligo methods

Integrated DNA Technologies (IDT) will host an informative webinar, entitled ‘Knockdown of lncRNAs: exploring RNAi and antisense oligo methods’, on Tuesday, August 25, 2015. Kim Lennox, a research scientist at IDT and expert in the suppression of gene expression, will present the webinar at 9 am and 1 pm Central Standard Time.

From Integrated DNA Technologies 19 Aug 2015

Save a child with asthma with a disposable paper cup

A disposable cup – favoured by many of the high street’s well known coffee shops – is the inspiration behind a new and scientifically reviewed device for the safe and prompt treatment of school age children suffering acute asthma, which often presents as an emergency situation.

19 Aug 2015

Synthorx employs synthetic DNA technology to produce proteins containing novel amino acids

Synthorx Inc. announced today that the company has employed its proprietary protein expression system to successfully produce proteins containing novel amino acids. Using a semi-synthetic DNA template (containing the synthetic base pair X and Y), Synthorx scientists were able to produce RNA containing X and Y, which was used with an otherwise fully natural biological system, to efficiently direct the incorporation of multiple novel amino acids at different sites in proteins.

19 Aug 2015

Researchers capture images of immune cell interactions rallying to destroy herpes simplex virus

Doctor Scott Mueller and colleagues from the University of Melbourne's Department of Microbiology and Immunology at the Doherty Institute used state-of-the-art microscopy to painstakingly capture images of the interactions of three crucial types of immune cells rallying to destroy herpes simplex virus.

19 Aug 2015

Early exposure to inflammatory cytokines can paralyze CD4 T cells

In a discovery that is likely to rewrite immunology text books, researchers at UC Davis have found that early exposure to inflammatory cytokines, such as interleukin 2, can "paralyze" CD4 T cells, immune components that help orchestrate the body's response to pathogens and other invaders.

19 Aug 2015

Johns Hopkins scientists develop novel fish embryo technique to identify potential new treatments for diabetes

In experiments with 500,000 genetically engineered zebrafish embryos, Johns Hopkins scientists report they have developed a potentially better and more accurate way to screen for useful drugs, and they have used it to identify 24 drug candidates that increase the number of insulin-producing cells in the pancreas.

19 Aug 2015

MRI scanners can steer cell-based, tumour busting therapies to exact target sites in the body

Scientists from the University of Sheffield have discovered MRI scanners, normally used to produce images, can steer cell-based, tumour busting therapies to specific target sites in the body.

19 Aug 2015

Scientists identify new pathway that may protect brain from Alzheimer's disease

It is a hallmark of Alzheimer's disease: Toxic protein fragments known as amyloid-β clumped together between neurons in a person's brain.

19 Aug 2015

Bacteria in gut may be the cause of uveitis in the eye

The inflammatory eye disorder autoimmune uveitis occurs when a person's immune system goes awry, attacking proteins in the eye. What spurs this response is a mystery, but now a study on mice suggests that bacteria in the gut may provide a kind of training ground for immune cells to attack the eye.

19 Aug 2015

High pressure freezer with integrated light stimulation launched by Leica Microsystems

Leica Microsystems launches the Leica EM ICE, a new generation High-Pressure Freezer with fully integrated light stimulation option at the precision of a millisecond.

From Leica Microsystems GmbH 18 Aug 2015

Researchers at Forsyth Institute enhance pipetting efficiency using VIAFLO Assist

INTEGRA reports on how researchers at the renowned Forsyth Institute (Cambridge, MA) are using a VIAFLO Assist to enhance the efficiency while maintaining the accuracy of pipetting protocols related to the discovery, measurement, and validation of new biomarkers of disease that can be found in saliva.

From INTEGRA Biosciences 18 Aug 2015

Scientists discover special brain mechanism that can retrieve unconscious memories

Some stressful experiences - such as chronic childhood abuse - are so overwhelming and traumatic, the memories hide like a shadow in the brain.

18 Aug 2015

Researchers describe central role of mTOR in ageing and age-related diseases

For some, TOR may bring to mind a Celtic mountain or perhaps an Internet privacy group. In the world of molecular biology it's a cellular pathway that's found in everything from yeast to mammals.

18 Aug 2015

Avita Medical, University of Huddersfield partner to explore mechanism of Regenerative Epithelial Suspension

Avita Medical Ltd, a regenerative medicine company specialising in the treatment of wounds and skin defects, today announced that it has forged a partnership with the University of Huddersfield to explore the mechanism of Regenerative Epithelial Suspension (RESTM) - from Avita's ReCell device - to better understand its ability to effectively treat burns, hard-to-heal wounds and skin trauma.

18 Aug 2015

Study reports results of genetic testing for 22 genetic causes of neonatal diabetes

Over a 10 year period, the time that babies receive genetic testing after being diagnosed with diabetes has fallen from over four years to under two months. Pinpointing the exact genetic causes of sometimes rare forms of diabetes is revolutionising healthcare for these patients.

18 Aug 2015

Medical Science News

PHD1 inhibition may have therapeutic potential for colorectal cancer

Further understanding of genetic influence in ALS to be explored in new partnership

Scientists reveal link between smaller hippocampal brain volume and marijuana use

UC Davis researchers set out to identify biomarkers for early diagnosis of lung cancer

Discovery allows study of naturally occurring forms of HCV in the lab

IDT webinar explores effective RNAi and antisense oligo methods

Save a child with asthma with a disposable paper cup

Synthorx employs synthetic DNA technology to produce proteins containing novel amino acids

Researchers capture images of immune cell interactions rallying to destroy herpes simplex virus

Early exposure to inflammatory cytokines can paralyze CD4 T cells

Johns Hopkins scientists develop novel fish embryo technique to identify potential new treatments for diabetes

MRI scanners can steer cell-based, tumour busting therapies to exact target sites in the body

Scientists identify new pathway that may protect brain from Alzheimer's disease

Bacteria in gut may be the cause of uveitis in the eye

High pressure freezer with integrated light stimulation launched by Leica Microsystems

Researchers at Forsyth Institute enhance pipetting efficiency using VIAFLO Assist

Scientists discover special brain mechanism that can retrieve unconscious memories

Researchers describe central role of mTOR in ageing and age-related diseases

Avita Medical, University of Huddersfield partner to explore mechanism of Regenerative Epithelial Suspension

Study reports results of genetic testing for 22 genetic causes of neonatal diabetes

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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