Sickle Cell Disease News and Research

Latest Sickle Cell Disease News and Research

St. Jude announces $13 million investment to expand the understanding of G-protein coupled receptors

St. Jude Children's Research Hospital today announced a nearly $13 million investment toward a new research collaboration with scientists at Columbia University, Duke University and Stanford University to expand the understanding of G-protein coupled receptors (GPCR), which are vital proteins that impact human health and disease.

18 Jan 2024

Review of traditional treatments and novel nutritional interventions for sickle cell disease

Nutrition-related studies involving sickle cell disease (SCD) patients, particularly those in Africa.

17 Jan 2024

Simple biomarkers offer early warning of hidden heart risk in childhood cancer survivors

Data from the St. Jude lifetime cohort study (St. Jude LIFE) revealed that two common biomarkers of cardiac function and damage could better predict cardiomyopathy within five years than routine clinical evaluations in high-risk, asymptomatic childhood cancer survivors.

11 Jan 2024

Sickle cell patients lag behind in COVID vaccination despite higher risks

Despite the fact that people with sickle cell disease have a much higher risk of serious illness or death if they develop COVID-19, a new study shows they're also much less likely than those without sickle cell disease to have gotten vaccinated against coronavirus.

10 Jan 2024

Universal consensus definition unlocks research advancements for critically ill children worldwide

St. Jude Children's Research Hospital investigators collaborated with a global group of acute pediatric critical illness experts to reach a consensus definition of the condition.

9 Jan 2024

St. Jude scientists develop novel spectinomycin derivatives to combat Mycobacterium abscessus

Scientists at St. Jude Children's Research Hospital are tackling Mycobacterium abscessus (Mab) antibiotic resistance.

5 Jan 2024

Study: Two-thirds of babies with sickle cell disease are born to mothers living in disadvantaged areas

As if starting life with a potentially disabling genetic blood disease wasn't enough, a study shows that almost two-thirds of babies born with sickle cell disease are born to mothers who live in disadvantaged areas.

4 Jan 2024

Existing beta blocker investigated as novel sickle cell therapy

A beta blocker typically used to treat heart problems, hemangioma, migraines and anxiety could be a new therapeutic for patients with sickle cell disease. Researchers led by Ankit A. Desai, MD, associate professor of medicine at the Krannert Cardiovascular Research Center (KCVRC) at Indiana University School of Medicine, have been awarded a $3 million grant by the U.S. Department of Defense to evaluate the efficacy of this drug.

3 Jan 2024

St. Jude researchers crack the code of the β2-adrenergic receptor

Through an international collaboration, scientists at St. Jude Children's Research Hospital leveraged data science, pharmacology and structural information to conduct an atomic-level investigation into how each amino acid in the receptor that binds adrenaline contributes to receptor activity in the presence of this natural ligand.

22 Dec 2023

St. Jude researchers reveal structure of Parkinson's-linked proteins

Scientists at St. Jude Children's Research Hospital revealed the complex structure of two Parkinson's disease-related proteins, both of which are implicated in late-onset cases.

21 Dec 2023

Scientists identify genetic and epigenetic culprits behind bilateral Wilms tumor

Children with bilateral Wilms tumor have a tumor in each of their kidneys -; a condition that strongly suggests an underlying genetic or epigenetic predisposition driving the disease.

18 Dec 2023

St. Jude study sheds light on prediabetes prevalence and diabetes risk in childhood cancer survivors

A study from St. Jude Children's Research Hospital sheds light on the incidence of prediabetes and diabetes in childhood cancer survivors for better prevention and treatment.

13 Dec 2023

Many patients may not benefit from gene-editing treatments for sickle cell disease

Federal approval of a breakthrough gene-editing technology that treats the pain and debilitating effects of sickle cell disease is cause for celebration among a community with few options for relief.

8 Dec 2023

New approach enhances CAR T-cell therapy for solid tumors

Immunotherapy using modified chimeric antigen receptor (CAR) T cells has greatly improved survival rates for pediatric patients with relapsed and recurrent leukemia.

30 Nov 2023

Scientists uncover new therapeutic targets for high-risk pediatric leukemia

Scientists at St. Jude Children's Research Hospital comprehensively identified genes directly regulated by a protein associated with high-risk pediatric leukemias.

28 Nov 2023

New CRISPR approach shows promise for treating glioblastoma

The gene-editing technology CRISPR shows early promise as a therapeutic strategy for the aggressive and difficult-to-treat brain cancer known as primary glioblastoma, according to findings of a new study from Gladstone Institutes.

27 Nov 2023

Sickle Cell Disease patients and the use of disease-modifying treatments

New disease-modifying treatments (DMTs), namely, crizanlizumab, L-glutamine, and voxelotor, have recently been approved.

23 Nov 2023

St. Jude scientists discover potential CAR T cell therapy target for brain and solid tumors

Findings from St. Jude Children's Research Hospital are moving the field of cancer immunotherapy one step closer to treating brain and solid tumors.

21 Nov 2023

Scientists uncover key to enhancing cancer-killing T cells

T cells are the key immune system component involved in killing cancer. Tumors produce signals that turn off these T cells, partially by forcing them to progressively differentiate (mature) into a hypofunctional state known as exhaustion.

21 Nov 2023

Long-term monitoring of gene therapy patients crucial for safety, study says

Medical research has shown promising results regarding the potential of gene therapy to cure genetic conditions such as sickle cell disease and the findings of this study, published in Nature Medicine, offer important new insights into processes happening in the body after treatment.

16 Nov 2023

Sickle Cell Disease News and Research

Latest Sickle Cell Disease News and Research

St. Jude announces $13 million investment to expand the understanding of G-protein coupled receptors

Review of traditional treatments and novel nutritional interventions for sickle cell disease

Simple biomarkers offer early warning of hidden heart risk in childhood cancer survivors

Sickle cell patients lag behind in COVID vaccination despite higher risks

Universal consensus definition unlocks research advancements for critically ill children worldwide

St. Jude scientists develop novel spectinomycin derivatives to combat Mycobacterium abscessus

Study: Two-thirds of babies with sickle cell disease are born to mothers living in disadvantaged areas

Existing beta blocker investigated as novel sickle cell therapy

St. Jude researchers crack the code of the β2-adrenergic receptor

St. Jude researchers reveal structure of Parkinson's-linked proteins

Scientists identify genetic and epigenetic culprits behind bilateral Wilms tumor

St. Jude study sheds light on prediabetes prevalence and diabetes risk in childhood cancer survivors

Many patients may not benefit from gene-editing treatments for sickle cell disease

New approach enhances CAR T-cell therapy for solid tumors

Scientists uncover new therapeutic targets for high-risk pediatric leukemia

New CRISPR approach shows promise for treating glioblastoma

Sickle Cell Disease patients and the use of disease-modifying treatments

St. Jude scientists discover potential CAR T cell therapy target for brain and solid tumors

Scientists uncover key to enhancing cancer-killing T cells

Long-term monitoring of gene therapy patients crucial for safety, study says

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

Sickle Cell Disease News and Research

Latest Sickle Cell Disease News and Research

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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