Breast Cancer Classification

By Dr Ananya Mandal, MD

Breast cancers can be classified on the basis of four schemes. Each of these schemes classify the cancers based on different criteria and serve a different purpose. Some of these are:

Classification based on pathology

The cancer is classified according to its cellular structure and microanatomy. This is the commonest for of classification or typing the breast cancer.

This picture shows ductal carcinoma in situ.
This picture shows ductal carcinoma in situ.
This picture shows ductal carcinoma in situ.
This picture shows cancer cells spreading outside the duct. The cancer cells are invading nearby tissue inside the breast.

Classification according to grade

The pathologist classifies the cancer according to grade. A ''well-differentiated'' tumor for example is low grade and resembles normal tissue. A ''poorly differentiated'' tumor is composed of disorganized cells and, therefore, does not look like normal tissue and is termed high grade. Some are ''moderately differentiated'' or intermediate grade as well.

Classification based on stage of cancer

This is the most commonly used scheme of determining the stage of cancer and the TNM staging that takes into account the Tumor size, lymph Node involvement and Metastasis or spread of the cancer.

Protein & gene status

All breast cancers these days are tested for expression, or detectable effect, of the estrogen receptor (ER), progesterone receptor (PR) and HER2/neu proteins. These tests utilize principles of immunohistochemistry and once the status of these proteins it known, prognosis can be predicted and certain novel therapies may be chosen for treatment.

Histological appearance

Breast cancer is usually, but not always, primarily classified by its histological appearance. Some of the histological types include:

Ductal Carcinoma in situ (DCIS)

This signifies a very early form of cancer that has not spread. DCIS is a type of early breast cancer inside of the ductal system that has not attacked the nearby tissue. It is one of the common types of non-invasive cancer

Infiltrating or invasive ductal carcinoma (IDC)

This is the most common type of breast cancer. It starts in the milk ducts and spreads to surrounding tissues. This can also spread to other parts of the body via lymph channels and blood stream.

Medullary carcinoma

This forms around 15% of all breast cancers. It affects middle aged women more commonly and the cellular histology resembles the medulla (gray matter) of the brain.

Lobular Carcinoma in situ (LCIS)

This is a rarer form of non-invasive tumor. It usually does not develop into invasive cancer. LCIS is more of a “marker” or signal that breast cancer may develop. LCIS has recently been renamed lobular neoplasia.

Infiltrating Lobular Carcinoma (ILC)

This is the second most common type of breast cancer after invasive ductal carcinoma. The cancer begins in the lobules or lobes and spreads to other parts of the body. There is initial appearance of a thickening in the upper-outer section of the breast. These are usually positive for estrogen and progesterone receptors and thus may be treated successfully with hormone therapy.

Tubular carcinoma

The cancer cells appear like tiny tubules. This type of breast cancer is typically found in women aged 50 and above. This tumor responds well to treatment

Mucinous carcinoma or colloid

This is rare type of invasive breast cancer that rarely spreads to the lymph nodes. The cancer cells produce mucus and these cells are distinct from normal cells under a microscope. The mucous and cancer cells combine to form jelly-like tumors. 

Paget’s disease

This leads to an eczema-like change in the skin of the nipple. There is itchiness, scaling and oozing discharge from the nipple. 90% of the women who experience these symptoms have an underlying breast cancer. Paget’s Disease can occur at any age but will more likely occur in women who are in their 50s.

Inflammatory breast cancer

This is a rare but aggressive type of breast cancer. The cancer leads to blockage of the lymph vessels in the skin of the breast. The cancer appears to cover the breast over a large area like a sheet rather than a lump. The breast appears swollen, red and inflamed.

Triple negative breast cancer

Breast tumor that is negative for estrogen receptor (ER), progesterone receptor (PR) and HER2/neu proteins.

Metastatic breast cancer

This is a later stage of breast cancer when it has spread to other organs like liver, brain, bones etc.

Reviewed by , BA Hons (Cantab)

Further Reading

Last Updated: Sep 22, 2013

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