Notable definitions include:—the most widely used clinical and research description of CFS, The 1994 criteria require the presence of four or more symptoms beyond fatigue, where the 1988 criteria require six to eight.—includes CFS of unknown etiology and a subtype called post-infectious fatigue syndrome (PIFS). Important differences are that the presence of mental fatigue is necessary to fulfill the critera and symptoms are accepted that may suggest a psychiatric disorder.—this definition requires the presence of symptoms from at least one category of autonomic, neuroendocrine, or immune symptoms. An important difference is the Canadian definition excludes patients with symptoms of mental illness.
Using different case definitions may influence the types of patients selected and there is research to suggest subtypes of patients or disease exist. Clinical practice guidelines, with the aim of improving diagnosis, management, and treatment, are generally based on case descriptions. An example is the CFS/ME guideline for the National Health Service in England and Wales, produced in 2007 by the National Institute for Health and Clinical Excellence (NICE).
Further Reading
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"Chronic Fatigue Syndrome"
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