Mortality rates from pulmonary fibrosis (PF) have increased significantly in recent years, and are predicted to continue to rise, according to researchers from the University of Colorado.
Between 1992 and 2003, the age-adjusted mortality rate from PF—an often fatal disease which involves scarring of the lung—rose by nearly 28.4 percent in men, and 41.3 percent in women. Over the same time period, an increasing percentage of patients with PF died of the disease itself rather than of coexisting conditions.
“Rates rise with increasing age, are highest among older people, and are consistently higher in men than in women,” wrote the researchers. “However, mortality rates in women with PF are climbing more rapidly than in men.”
The study, led by Amy Olsen, M.D., M.S.P.H., of the University of Colorado Health Sciences Center, appears in the August 1, 2007, issue to the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.
Dr. Olson and five colleagues analyzed the cause of death listed on death certificates for more than 28 million decedents using data compiled by the National Center for Health Statistics. Of that larger group, more than 175,000 deaths were linked to PF. In developing a model to predict future mortality rates, the researchers applied a multivariable analysis to current data, finding a predicted significant increase in men over the age of 65 and for women in all age categories.
“Our study is the first large-scale study to examine age-, sex-, race-, and ethnicity-stratified mortality rates in decedents with PF,” said Dr. Olson.
In addition to finding a large disparity in mortality rates among women and men, which researchers suggest may be attributable to changes in historically gendered smoking patterns, they also found significant differences among racial and ethnic lines. Age-adjusted mortality rates among whites were higher than among blacks or Hispanics and increasing more quickly than in other racial and ethnic groups. Although previous studies have suggested that whites are more likely to be diagnosed with PF, differences in race or ethnicity “may also play a role in susceptibility,” the researchers note, and merit further examination.