Ongoing research at Missouri University of Science and Technology has uncovered a new method for the early detection of cancer with the potential to save millions of lives.
Dr. Yinfa Ma, Curators' Teaching Professor of chemistry at Missouri S&T, has developed a non-invasive instrument for pre-cancer screening that not only detects cancer in the body, but is capable of predicting the cancer's type and severity using a group of biomarkers.
“Cancer is the second-highest cause of death among all diseases,” Ma says. “Early diagnosis of cancer is crucial, but not many people want to go to the hospital to undergo costly, invasive cancer screening.”
Ma's research builds on existing knowledge of pteridines, compounds found within the body that serve as important cofactors to regulate the metabolism of cells. Ma found that six pteridine derivatives can be detected in urine samples, and that levels of some pteridines increase significantly if there is a tumor inside the body. Most importantly, Ma discovered that one molecule, called oncopterin, exists only in the urine of cancer patients, but not in healthy human subjects. Further testing for oncopterin, using different techniques, still is required.
Ma has developed a prototype of an instrument, called a P-scan, that can be used to screen urine for oncopterine and the six other pteridine bio markers. The oncopterin level in urine can be used to determine whether cancer is going to develop, and varying levels of the six pteridines can actually provide a “fingerprint” of the type of cancer.