Pieris enters multi-year collaboration with Sanofi-Aventis and Sanofi Pasteur for Anticalin technology

Pieris AG (http://www.pieris-ag.com/) announced today the signature of a collaboration and license agreement with both Sanofi-Aventis and Sanofi Pasteur, the vaccines division of the sanofi-aventis Group (EURONEXT: SAN and NYSE: SNY), under which Pieris will apply its proprietary Anticalin technology to discover novel Anticalin drugs against multiple targets, with further development undertaken by Sanofi-Aventis and Sanofi-Pasteur. The collaboration will initially involve two targets nominated by Sanofi-Aventis and Sanofi-Pasteur, and includes the option for four additional targets.

Anticalins (http://www.pieris-ag.com/technology/anticalins.php) are a novel generation of targeted therapeutics and are sourced from Pieris' proprietary libraries. They have the potential to overcome some of the constraints of monoclonal antibodies, thereby allowing novel therapeutic approaches.

"This multi-year collaboration underscores our strategy of developing a broad pipeline of therapeutic Anticalin drug candidates comprising partnered programs in addition to our proprietary drug portfolio," noted Stephen Yoder, CEO of Pieris. "The opportunity to collaborate with a pharmaceutical company of sanofi-aventis' caliber is an exciting step as we continue to demonstrate the diverse applicability of the Anticalin technology."

"Sanofi-Aventis' basic objective of finding new solutions to address patients' needs is furthered in this collaboration by exploiting innovative technology which focuses on some of the fundamental mechanisms of disease processes," commented Leopold Bertea, VP of the Scientific Core Platform, Biologics Center at sanofi-aventis. "Pieris' Anticalin technology will allow sanofi-aventis to take a more comprehensive approach to developing targeted therapeutics, as we believe the Anticalin technology will complement our existing suite of more conventional technologies."

Under the terms of the agreement, Pieris will receive EUR 3.5 million in an upfront payment for the first two targets, plus committed research funding and payments for the achievement of research, preclinical, regulatory and commercial milestones. Overall, the agreement could encompass for Pieris, per each product resulting from the collaboration, up to EUR 26.5 million in development milestones for the first therapeutic application and EUR 18 million in commercial milestones. Further milestones would be received by Pieris with respect to the same product in the case of development of that product in additional therapeutic applications. Payments will also include tiered royalties on sales of products resulting from the collaboration. Sanofi-Aventis and Sanofi Pasteur will have exclusive marketing rights worldwide for all such products.

SOURCE Pieris AG