Great Lakes NeuroTechnologies announced today that they have received $1.5 million in funding to commercialize a technology for Parkinson’s disease (PD) patients that will better assess motor symptoms in response to new deep brain stimulation (DBS) and pharmaceutical therapies.
The funding, provided by the National Institute of Neurological Disorders and Stroke, is focused on home-based technology to assess bradykinesia in PD. While tremor is often the most visible symptom of PD, bradykinesia can be the most impairing and is often used as a clinical trial endpoint.
Bradykinesia encompasses slowed movements, low amplitude movement, and hesitations or patients “getting stuck” when they try to move. The current standard in evaluating bradykinesia is the Unified Parkinson’s Disease Rating Scale, a subjective, qualitative ranking system. Scoring instructions for bradykinesia integrate multiple movement features into a single score that increases variability and limits exploration into how particular bradykinesia features are influenced by specific treatments. Capturing this data would allow novel therapies to target specific bradykinesia manifestations.
The funding will support the design, implementation, and clinical assessment of a portable, user-worn, bradykinesia feature extraction system for integration with Great Lake NeuroTechnologies’ Kinesia HomeView technology platform for home-based objective PD monitoring. “Telemedicine is a rapidly growing field and we aim to be at the forefront with this technology and its ability to capture PD symptom severities in the home,” said principal investigator and Biomedical Research Manager Dustin A. Heldman, Ph.D.
“With better quantification of different bradykinesia features, novel therapies may be developed to target a patient’s specific bradykinesia manifestations. Furthermore, this home-based platform for more continuous monitoring will allow the capture of complex symptom fluctuation patterns in response to treatment.” As one important example, home monitoring may be particularly important when evaluating motor symptom response to DBS since, unlike tremor, bradykinesia can take up to an hour to respond.