Hippocampus News and Research

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The hippocampus is a part of the forebrain, located in the medial temporal lobe. It belongs to the limbic system and plays major roles in short term memory and spatial navigation. Humans and other mammals have two hippocampi, one in each side of the brain.

Lundbeck, Otsuka to continue development of Lu AE58054 compound for Alzheimer's disease

H. Lundbeck A/S and Otsuka Pharmaceutical Co., Ltd. announced today the continuation of the development program of Lu AE58054 for the treatment of Alzheimer's disease, initiating the first out of four phase III clinical trials with the compound.

10 Oct 2013

People with high amounts of abdominal fat are likely to develop memory loss

Although problems with memory become increasingly common as people age, in some persons, memories last long time, even a life time. On the other hand, some people experience milder to substantial memory problems even at an earlier age.

10 Oct 2013

Epigenetic regulation linked with pathogenesis of Alzheimer's disease

New evidence presented at the 26th ECNP Congress linking epigenetic regulation with Alzheimer's disease may one day lead to new early diagnostic tests and even novel treatment options for the most common form of dementia.

7 Oct 2013

Researchers examine why depression messes with memory

To pinpoint why depression messes with memory, researchers took a page from Sesame Street's book. The show's popular game "One of these things is not like the others" helps young viewers learn to differentiate things that are similar - a process known as "pattern separation."

4 Oct 2013

Study indicates that RNA translation is dictated by translational hotspots

Protein synthesis in the extensions of nerve cells, called dendrites, underlies long-term memory formation in the brain, among other functions. "Thousands of messenger RNAs reside in dendrites, yet the dynamics of how multiple dendrite messenger RNAs translate into their final proteins remain elusive," says James Eberwine, PhD, professor of Pharmacology, Perelman School of Medicine at the University of Pennsylvania, and co-director of the Penn Genome Frontiers Institute.

27 Sep 2013

Research on bone-derived hormone could lead to new treatments for memory loss, depression

Researchers from Columbia University Medical Center (CUMC) have found that the skeleton, acting through the bone-derived hormone osteocalcin, exerts a powerful influence on prenatal brain development and cognitive functions such as learning, memory, anxiety, and depression in adult mice.

27 Sep 2013

MGH researchers identify rare gene mutations that appear to cause late-onset AD

Massachusetts General Hospital (MGH) researchers have identified and validated two rare gene mutations that appear to cause the common form of Alzheimer's disease (AD) that strikes after the age of 60.

25 Sep 2013

Researchers identify molecular pathway linking ICU ventilation to brain damage

At least 30 percent of patients in intensive care units (ICUs) suffer some form of mental dysfunction as reflected in anxiety, depression, and especially delirium. In mechanically-ventilated ICU patients, the incidence of delirium is particularly high, about 80 percent, and may be due in part to damage in the hippocampus, though how ventilation is increasing the risk of damage and mental impairment has remained elusive.

25 Sep 2013

Environmental enrichment protects against atrophy in chronic stages of TBI

For the first time, scientists at Toronto Rehab have found that in people with chronic moderate-severe traumatic brain injury (TBI), atrophy (shrinkage) in the brain may be countered by participating in environmental enrichment - increased physical, social and cognitive stimulation.

24 Sep 2013

NCI Funds Development Of Chrysalis’ Brain Tissue Damage Treatment

The National Cancer Institute awarded Chrysalis BioTherapeutics a $1.5 million contract to continue development of Chrysalin® to mitigate radiotherapy-induced damage to normal brain tissue. The project is a collaboration between Chrysalis, Baylor College of Medicine, and the University of Texas Medical Branch (UTMB).

24 Sep 2013

Protecting stem cells around hippocampus in brain reduces rate of memory loss in cancer patients

Protecting the stem cells that reside in and around the hippocampus - a C-shaped area in the temporal lobe on both sides of the brain associated with the ability to form and store memories - substantially reduces the rate of cancer patients' memory loss during whole-brain radiotherapy without a significant risk of recurrence in that area of the brain, a new study shows.

24 Sep 2013

Evidence shows that fear memories can be reduced during sleep

A fear memory was reduced in people by exposing them to the memory over and over again while they slept. It's the first time that emotional memory has been manipulated in humans during sleep, report Northwestern Medicine- scientists.

23 Sep 2013

Research on synapse stabilization aids understanding of autism, schizophrenia, intellectual disability

When we're born, our brains aren't very organized. Every brain cell talks to lots of other nearby cells, sending and receiving signals across connections called synapses.

21 Sep 2013

Small alteration in a brain gene contributes to risk for anxiety, depression and memory loss

Researchers at Weill Cornell Medical College have discovered why a tiny alteration in a brain gene, found in 20 percent of the population, contributes to the risk for anxiety, depression and memory loss.

20 Sep 2013

Studies reveal functioning of nerve cells in entorhinal cortex

The entorhinal cortex is a link between the brain's memory centre, the hippocampus, and the other areas of the brain. It is, however, more than an interface that only transfers nervous impulses.

20 Sep 2013

Research discovery suggests whole new frontier in human and animal brain functioning

Researchers from the University of Montreal and their colleagues have found brain activity beyond a flat line EEG, which they have called Nu-complexes (from the Greek letter).

19 Sep 2013

New information about how estrogens regulate memory formation

The loss of estrogens at menopause increases a woman's risk of dementia and Alzheimer's disease, yet hormone replacement therapy can cause harmful side effects.

19 Sep 2013

Discovery of gene essential for memory extinction could lead to new PTSD treatments

If you got beat up by a bully on your walk home from school every day, you would probably become very afraid of the spot where you usually met him. However, if the bully moved out of town, you would gradually cease to fear that area.

19 Sep 2013

Study reveals olive leaf extract can inhibit lead-induced brain injury

In recent years, neurotoxicity from exposure to low levels of lead in the environment has become increasingly prevalent. Therefore, the discovery of herbs that have lead-eliminating properties without harmful side effects is essential for the management of lead poisoning.

17 Sep 2013

Research suggests possibility of using cell transplants to treat schizophrenia

Research from the School of Medicine at The University of Texas Health Science Center at San Antonio suggests the exciting possibility of using cell transplants to treat schizophrenia.

10 Sep 2013