Joint press release of the DZNE and Charite-Universitaetsmedizin Berlin
The entorhinal cortex is a link between the brain's memory centre, the hippocampus, and the other areas of the brain. It is, however, more than an interface that only transfers nervous impulses. The entorhinal cortex also has an independent role in learning and thinking processes. This is particularly applicable for spatial navigation. "We know precious little about how this happens," says Prof. Dietmar Schmitz, a researcher at the Cluster of Excellence NeuroCure at the Charit- - Universit-tsmedizin Berlin and Site Speaker for the DZNE in Berlin. "This is why we are investigating in animal models how the nerve cells within the entorhinal cortex are connected with each other."
Signals wander inside the brain as electrical impulses from nerve cell to nerve cell. In general, signals are not merely forwarded. Rather, operation of the brain critically depends on the fact that the nerve impulses in some situations are activated and in other cases suppressed. A correct balance between suppression and excitation is decisive for all brain processes. "Until now research has mainly concentrated on signal excitation within the entorhinal cortex. This is why we looked into inhibition and detected a gradient inside the entorhinal cortex," explains Dr. Prateep Beed, lead author of the study. "This means that nerve signals are not suppressed equally. The blockage of the nerve signals is weaker in certain parts of the entorhinal cortex and stronger in others. The inhibition has, so to speak, a spatial profile."