Antibody News and Research

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An antibody is a blood protein that is produced in response to and counteracts an antigen. Antibodies are produced in response to disease and help the body fight against the particular disease. In this way, antibodies help the body develop an immunity to disease.

Scientists detect blood biomarker that may help in early diagnosis of children with ASD

Researchers at UT Southwestern Medical Center have identified a blood biomarker that may aid in earlier diagnosis of children with autism spectrum disorder, or ASD.

4 May 2016

LJI study could provide important target for autoimmune disease interventions

Follicular helper T cells (Tfh cells), a rare type of T cells, are indispensable for the maturation of antibody-producing B cells. They promote the proliferation of B cells that produce highly selective antibodies against invading pathogens while weeding out those that generate potentially harmful ones.

3 May 2016

Mepolizumab has no hint of added benefit in eosinophilic asthma

The monoclonal antibody mepolizumab has been approved since the end of 2015 for the treatment of adults with severe refractory eosinophilic asthma. The German Institute for Quality and Efficiency in Health Care now examined in an early benefit assessment whether the drug offers an added benefit for patients in comparison with the appropriate comparator therapy.

3 May 2016

Addition of L19-IL2 can increase radiation therapy-induced immune response against tumours

Radiation therapy not only kills cancer cells, but also helps to activate the immune system against their future proliferation. However, this immune response is often not strong enough to be able to cure tumours, and even when it is, its effect is limited to the area that has been irradiated.

2 May 2016

Single bNAb infusion can protect monkeys from HIV-like virus infection

A single antibody infusion can protect monkeys against infection with an HIV-like virus for up to 23 weeks, researchers have found. The study, published in Nature, was led by scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and The Rockefeller University.

28 Apr 2016

TSRI study reveals important traits in LCMV, Lassa virus

For the first time, scientists at The Scripps Research Institute (TSRI) have solved the structure of the biological machinery used by a common virus to recognize and attack human host cells.

27 Apr 2016

HDM SLIT tablet can reduce risk of moderate or severe asthma exacerbation

The addition of a house dust mite (HDM) sublingual allergen immunotherapy (SLIT) tablet to maintenance medications improved time to first moderate or severe asthma exacerbation during a period of inhaled corticosteroid (ICS) reduction among adults with HDM allergy-related asthma not well controlled by ICS, according to a study appearing in the April 26 issue of JAMA.

27 Apr 2016

Series of routine tests may not be beneficial to patients with age-related disorder

A series of tests physicians routinely order to help diagnose and follow their patients with an elevated antibody level that is a marker for cancer risk, often do not benefit the patient but do increase health care costs, pathologists report.

27 Apr 2016

Newly published manuscripts enhance understanding of the immune system

MedImmune, the global biologics research and development arm of AstraZeneca, today announced that it has achieved a significant scientific milestone by publishing three manuscripts in Nature Immunology that advance the understanding of the immune system and highlight underlying mechanisms in two little-understood disease areas -- chronic obstructive pulmonary disease (COPD) and systemic lupus erythematosus (SLE).

26 Apr 2016

Administering flu vaccinations in the morning could induce greater antibody responses

New research from the University of Birmingham has shown that flu vaccinations are more effective when administered in the morning.

26 Apr 2016

New study finds no increase in food-specific IgE levels linked to food allergies

A new study using 5,000 stored blood samples found no increase in the presence of food-specific immunoglobulin E (IgE) — a blood marker associated with food allergy — in children's blood between the 1980s and the 2000s.

26 Apr 2016

Rituximab outperforms fingolimod after natalizumab switch

Rituximab is more effective and better tolerated than fingolimod for patients with multiple sclerosis needing to switch from natalizumab due to JC-virus antibody positivity, research suggests.

26 Apr 2016

Immunology experts aim to develop point-of-care test for early detection of Lyme disease

As part of the EU "ID Lyme" project, the infection immunology working group at the Institute for Hygiene and Applied Immunology at the Center for Pathophysiology, Infectiology and Immunology at the Medical University of Vienna is working on developing of a new test for early detection of Lyme disease (borreliosis).

25 Apr 2016

Scientists examine PD-1-expressing regulatory T cells in aggressive brain cancer

Immunotherapy represents an exciting advance in cancer treatment that harnesses the immune system to seek and destroy cancer cells.

22 Apr 2016

Study paves way for refining antibody-based cancer immunotherapy

A study coordinated by the Malmberg Laboratory at Oslo University Hospital/University of Oslo and the Karolinska Institute, published in Cell Reports, reveals a molecule that trigger cancer recognition in natural killer (NK) cells.

22 Apr 2016

Infected mice can be better models for human diseases

Vaccines and therapeutics developed using mice often don't work as expected in humans. New research at Washington University School of Medicine in St. Louis points to the near-sterile surroundings of laboratory mice as a key reason.

21 Apr 2016

Novel gene therapy can improve symptoms of Bubble Boy disease in young adults

Adolescents and young adults with a severe inherited immunodeficiency disorder improved following treatment with novel gene therapy developed at St. Jude Children's Research Hospital and at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health. The results of this study appear today in the journal Science Translational Medicine.

21 Apr 2016

Proteins can be used as targets to deliver drugs into stressed cancer cells

Targeted missiles that can enter cancer cells and deliver lethal cell toxins without harming surrounding healthy tissue. This has been a long-standing vision in cancer research, but it has proved difficult to accomplish. A research group at Lund University in Sweden has now taken some crucial steps in this direction.

20 Apr 2016

New study suggests re-evaluation of long-held method to predict effectiveness of seasonal influenza vaccine

The long-held approach to predicting seasonal influenza vaccine effectiveness may need to be revisited, new research suggests. Currently, seasonal flu vaccines are designed to induce high levels of protective antibodies against hemagglutinin (HA), a protein found on the surface of the influenza virus that enables the virus to enter a human cell and initiate infection.

20 Apr 2016

Medi-551 antibody treatment decreases number of cancer stem cells by half in multiple myeloma patients

An experimental antibody treatment decreased by half the number of cancer stem cells that drive the growth of tumors in nearly all patients with multiple myeloma, a cancer of the bone marrow and bone tissue, according to results of a preliminary clinical trial led by Johns Hopkins Kimmel Cancer Center scientists.

18 Apr 2016

Antibody News and Research

Further Reading

Scientists detect blood biomarker that may help in early diagnosis of children with ASD

LJI study could provide important target for autoimmune disease interventions

Mepolizumab has no hint of added benefit in eosinophilic asthma

Addition of L19-IL2 can increase radiation therapy-induced immune response against tumours

Single bNAb infusion can protect monkeys from HIV-like virus infection

TSRI study reveals important traits in LCMV, Lassa virus

HDM SLIT tablet can reduce risk of moderate or severe asthma exacerbation

Series of routine tests may not be beneficial to patients with age-related disorder

Newly published manuscripts enhance understanding of the immune system

Administering flu vaccinations in the morning could induce greater antibody responses

New study finds no increase in food-specific IgE levels linked to food allergies

Rituximab outperforms fingolimod after natalizumab switch

Immunology experts aim to develop point-of-care test for early detection of Lyme disease

Scientists examine PD-1-expressing regulatory T cells in aggressive brain cancer

Study paves way for refining antibody-based cancer immunotherapy

Infected mice can be better models for human diseases

Novel gene therapy can improve symptoms of Bubble Boy disease in young adults

Proteins can be used as targets to deliver drugs into stressed cancer cells

New study suggests re-evaluation of long-held method to predict effectiveness of seasonal influenza vaccine

Medi-551 antibody treatment decreases number of cancer stem cells by half in multiple myeloma patients

Immunology eBook

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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