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Crohn’s disease is a chronic inflammatory disease of the bowel affecting at least 115,000 people in the UK. The condition usually develops in teenagers and young adults, but can be diagnosed at any age and is equally common in men and women.

The condition can affect any part of the digestive tract between the mouth and the anus, although inflammation in the last section of the small bowel (ileum) or the first part of the large bowel (colon) is most common.

Crohn's disease is a ‘relapsing and remitting’ condition characterized by symptom-free periods followed by episodes of “flare-ups,” during which symptoms such as diarrhoea, abdominal pain, fever and fatigue may become particularly bothersome.

Long term, severe inflammation can damage sections of the digestive system, resulting in additional complications, such as a tear in the wall of the anus (fissure), narrowing of the intestine (stricture) or the formation of an abnormal connection between the bowel and another body part such as the bladder, vagina or skin (fistula). Such problems usually require surgical treatment to correct. Crohn's disease also increases the risk of developing bowel cancer.

The exact cause of Crohn's disease is not clear but experts believe a combination of factors may be at work including genetics, immune responses to certain bacteria or viruses and lifestyle factors such as diet or smoking status.
IBD diagnosis in childhood does not affect educational achievements and lifestyle, study finds

IBD diagnosis in childhood does not affect educational achievements and lifestyle, study finds

Twenty-five percent of inflammatory bowel disease (IBD) patients are diagnosed as children or adolescents -- at the peak of their social and educational development. [More]
Anti-inflammatory drugs may improve severity of depressive symptoms, study finds

Anti-inflammatory drugs may improve severity of depressive symptoms, study finds

Anti-inflammatory drugs similar to those used to treat conditions such as rheumatoid arthritis and psoriasis could in future be used to treat some cases of depression, concludes a review led by the University of Cambridge, which further implicates our immune system in mental health disorders. [More]
Scientists at NIH and Emory University induce sustained remission in SIV-infected monkeys

Scientists at NIH and Emory University induce sustained remission in SIV-infected monkeys

Scientists at the National Institutes of Health and Emory University have experimentally induced sustained remission of SIV, the simian form of HIV, in infected monkeys. [More]
Crohn's disease appears to have two distinct genetic subtypes, study finds

Crohn's disease appears to have two distinct genetic subtypes, study finds

Crohn's disease, a common inflammatory disorder of the intestinal tract, can have devastating consequences for a patient's quality of life and is notoriously hard to treat successfully, in part because its course and severity vary so much from one case to the next. [More]
Common food-poisoning bacteria linked to increased risk of Crohn's disease

Common food-poisoning bacteria linked to increased risk of Crohn's disease

People who retain a particular bacterium in their gut after a bout of food poisoning may be at an increased risk of developing Crohn's disease later in life, according to a new study led by researchers at McMaster University. [More]
Researchers to investigate similarities between Crohn's and Johne's disease that affects cattle

Researchers to investigate similarities between Crohn's and Johne's disease that affects cattle

Researchers still have a lot to learn about Crohn's disease, a chronic form of inflammatory bowel disorder that affects as many as 700,000 Americans. [More]
Scientists reveal molecular elements that bridge anxiety and metabolism

Scientists reveal molecular elements that bridge anxiety and metabolism

Metabolic and anxiety-related disorders both pose a significant healthcare burden, and are in the spotlight of contemporary research and therapeutic efforts. Although intuitively we assume that these two phenomena overlap, the link has not been proven scientifically. [More]
FDA approves new biosimilar for multiple inflammatory diseases

FDA approves new biosimilar for multiple inflammatory diseases

The U.S. Food and Drug Administration today approved Amjevita (adalimumab-atto) as a biosimilar to Humira (adalimumab) for multiple inflammatory diseases. [More]
Groundbreaking research findings could lead to potential new treatments for Crohn’s disease

Groundbreaking research findings could lead to potential new treatments for Crohn’s disease

A Case Western Reserve University School of Medicine-led team of international researchers has for the first time identified a fungus as a key factor in the development of Crohn's disease. [More]
Study suggests interactions between distant DNA regions may impact disease gene levels

Study suggests interactions between distant DNA regions may impact disease gene levels

A person's DNA sequence can provide a lot of information about how genes are turned on and off, but new research out of Case Western Reserve University School of Medicine suggests the 3-D structure DNA forms as it crams into cells may provide an additional layer of gene control. [More]
Researchers discover new strategy to boost effectiveness of anti-cancer immune therapy

Researchers discover new strategy to boost effectiveness of anti-cancer immune therapy

Researchers at University of California San Diego School of Medicine and Moores Cancer Center have identified a strategy to maximize the effectiveness of anti-cancer immune therapy. [More]
Researchers uncover specific sites in the genome linked to high blood pressure

Researchers uncover specific sites in the genome linked to high blood pressure

Three large, collaborating international consortia of researchers, including a team co-led by investigators from Brigham and Women's Hospital, have uncovered new genes and sites in the genome tied to elevated blood pressure, implicating certain biological pathways and pointing toward new therapeutic strategies for treating hypertension. [More]
Patients with noninfectious uveitis can get effective treatment from corticosteroid alternative

Patients with noninfectious uveitis can get effective treatment from corticosteroid alternative

Patients suffering from noninfectious uveitis, a group of diseases that causes eye inflammation, can get effective treatment from a corticosteroid alternative that has previously been approved for treatment of arthritis and Crohn's disease, according to a study led by a Duke Health researcher. [More]
New discovery could potentially lead to treatments for Crohn's disease

New discovery could potentially lead to treatments for Crohn's disease

Scientists at the University of British Columbia have made a discovery that could potentially lead to treatments for a debilitating complication of Crohn's disease. [More]
Research strongly links smoking to bowel condition relapses

Research strongly links smoking to bowel condition relapses

Smoking is strongly linked to relapse of a serious bowel condition, research has confirmed. [More]
Crohn's disease sufferers experience slower cognitive response times, study shows

Crohn's disease sufferers experience slower cognitive response times, study shows

New research published in the UEG Journal1 has found that Crohn's disease sufferers experience slower response times than matched individuals that do not have the disease. [More]
Penn scientists develop combined medical and surgical care plan for managing Crohn's disease

Penn scientists develop combined medical and surgical care plan for managing Crohn's disease

The first published combined medical and surgical care plan for managing septic perianal Crohn's disease, a serious complication that occurs in around 40 percent of Crohn's disease patients, has been developed by researchers at Penn State College of Medicine. [More]
Ginger-derived nanoparticles may be good medicine for inflammatory bowel disease

Ginger-derived nanoparticles may be good medicine for inflammatory bowel disease

A recent study by researchers at the Atlanta Veterans Affairs Medical Center took them to a not-so-likely destination: local farmers markets. They went in search of fresh ginger root. [More]
Drugs designed to target nervous system could control inflammation in the gut, study shows

Drugs designed to target nervous system could control inflammation in the gut, study shows

There's a reason it's called a gut feeling. The brain and the gut are connected by intricate neural networks that signal hunger and satiety, love and fear, even safety and danger. These networks employ myriad chemical signals that include dopamine, a powerful neurotransmitter most famous for its role in reward and addiction. [More]
New technology uses natural nano-scale lipid transport system to deliver drugs straight to bloodstream

New technology uses natural nano-scale lipid transport system to deliver drugs straight to bloodstream

For years scientists and dieticians have argued over the health benefits of dietary fat. Research published this week, however, shows that piggybacking onto natural fat absorption pathways can dramatically enhance the utility of some drugs. [More]
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